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Matrix metalloproteinases (MMPs) are a major group of proteases known to regulate the turn-over of ECM and so they are suggested to be important in tissue remodelling observed during fibrogenic process associated with chronic inflammation. Tissue remodelling is the result of an imbalance in the equilibrium of the normal processes of synthesis and degradation of ECM components markedly controlled by the MMPs\/TIMP imbalance. We previously showed an association of the differences in collagen deposition in the lungs of bleomycin-treated mice with a reduced molar pro-MMP-9\/TIMP-1 ratio. Using the carbon tetrachloride (CCl4) preclinical model of liver fibrosis in mice, we observed a significant increase in collagen deposition with increased expression and release of tissue inhibitors of metalloproteinase (TIMP)-1 both at 24\u00a0h and 3\u00a0weeks later. This suggests an early altered regulation of matrix turnover involved in the development of fibrosis. We also demonstrated an activation of NLRP3-inflammasome pathway associated with the IL-1R\/MyD88 signalling in the development of experimental fibrosis both in lung and liver. This was also associated with an increased expression of purinergic receptors mainly P2X7. Finally, these observations emphasize those effective therapies for these disorders must be given early in the natural history of the disease, prior to the development of tissue remodelling and fibrosis.<\/jats:p>","DOI":"10.1042\/bsr20160107","type":"journal-article","created":{"date-parts":[[2016,5,31]],"date-time":"2016-05-31T23:08:42Z","timestamp":1464736122000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":172,"title":["Involvement of matrix metalloproteinases (MMPs) and inflammasome pathway in molecular mechanisms of fibrosis"],"prefix":"10.1042","volume":"36","author":[{"given":"Sacha","family":"Robert","sequence":"first","affiliation":[{"name":"UMR991 INSERM, Universit\u00e9 de Rennes 1, 35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Gicquel","sequence":"additional","affiliation":[{"name":"UMR991 INSERM, Universit\u00e9 de Rennes 1, 35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tatiana","family":"Victoni","sequence":"additional","affiliation":[{"name":"Laborat\u00f3rio de Reparo Tecidual, DHE\/IBRAG\/UERJ, 20550-170 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Valen\u00e7a","sequence":"additional","affiliation":[{"name":"Instituto de Ci\u00eancias Biom\u00e9dicas, Universidade Federal do Rio de Janeiro, 21941-902 Rio de Janeiro, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emiliano","family":"Barreto","sequence":"additional","affiliation":[{"name":"Laboratory of Cell Biology, Federal University of Alagoas, 57072-900 Macei\u00f3-AL, Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e9atrice","family":"Bailly-Ma\u00eetre","sequence":"additional","affiliation":[{"name":"INSERM, U1065, Facult\u00e9 de M\u00e9decine, Universit\u00e9 de Nice Sophia Antipolis, 06204 Nice, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Boichot","sequence":"additional","affiliation":[{"name":"UMR991 INSERM, Universit\u00e9 de Rennes 1, 35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lagente","sequence":"additional","affiliation":[{"name":"UMR991 INSERM, Universit\u00e9 de Rennes 1, 35043 Rennes, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2016,7,15]]},"reference":[{"key":"2021111618322772700_B1","doi-asserted-by":"publisher","first-page":"136","DOI":"10.7326\/0003-4819-134-2-200101160-00015","article-title":"Idiopathic pulmonary fibrosis: prevailing and evolving hypotheses about its pathogenesis and implications for therapy","volume":"134","author":"Selman","year":"2001","journal-title":"Ann. 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