{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T01:00:49Z","timestamp":1780102849913,"version":"3.54.0"},"reference-count":36,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":919,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:p>To evaluate (i) local coronary and systemic levels of microparticles (MP) in acute coronary syndrome (ACS) and stable angina pectoris (SAP) patients and (ii) their release after plaque disruption with percutaneous coronary intervention (PCI). MP are small vesicles originating from plasma membranes of cells after activation or apoptosis and are implicated in the pathogenesis of atherosclerosis. Neutrophils play a role in plaque destabilization and shed neutrophil-derived MP that have the potential to drive significant proinflammatory and thrombotic downstream effects. Eight ACS and eight SAP patients were included. Coronary sinus (CS) samples pre-intervention (CS1), 45 s following balloon angioplasty (CS2) and at 45 s intervals following stent deployment (CS3, CS4 and CS5), together with peripheral vein samples, pre- and post-PCI were analysed for neutrophil-derived (CD66b+), endothelial-derived (CD144+), platelet-derived (CD41a+), monocyte-derived (CD14+) and apoptotic (Annexin V+) MP. ELISA for interleukin (IL)-6, myeloperoxidase (MPO) and P-selectin was also performed. CD66b+ MP levels were similar in both groups pre-intervention. Post-PCI, CS levels rose significantly in ACS but not SAP patients (ACS area under the curve (AUC): 549 \u00b1 83, SAP AUC: 24 \u00b1 29, P&amp;lt;0.01). CS CD41a+, CD144+, CD14+ and Annexin V+ MP levels did not differ between groups. Acute neutrophil-derived MP release post-PCI occurs in ACS compared with stable patients, likely to be reflective of plaque MP content in vulnerable lesions.<\/jats:p>","DOI":"10.1042\/bsr20160430","type":"journal-article","created":{"date-parts":[[2016,12,3]],"date-time":"2016-12-03T03:10:28Z","timestamp":1480734628000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":26,"title":["Neutrophil-derived microparticles are released into the coronary circulation following percutaneous coronary intervention in acute coronary syndrome patients"],"prefix":"10.1042","volume":"37","author":[{"given":"Gonzalo\u00a0J.","family":"Mart\u00ednez","sequence":"first","affiliation":[{"name":"Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"},{"name":"Sydney Medical School, The University of Sydney, New South Wales, Australia"},{"name":"Divisi\u00f3n de Enfermedades Cardiovasculares, Pontificia Universidad Cat\u00f3lica de Chile, Santiago, Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer\u00a0Y.","family":"Barraclough","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"},{"name":"Sydney Medical School, The University of Sydney, New South Wales, Australia"},{"name":"Heart Research Institute, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirley","family":"Nakhla","sequence":"additional","affiliation":[{"name":"Heart Research Institute, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Kienzle","sequence":"additional","affiliation":[{"name":"Heart Research Institute, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stacy","family":"Robertson","sequence":"additional","affiliation":[{"name":"Sydney Medical School, The University of Sydney, New South Wales, Australia"},{"name":"Heart Research Institute, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziad","family":"Mallat","sequence":"additional","affiliation":[{"name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale (INSERM), Paris Cardiovascular Research Center, Paris, France"},{"name":"Division of Cardiovascular Medicine, University of Cambridge, Addenbrooke\u2019s Hospital, Cambridge, United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David\u00a0S.","family":"Celermajer","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"},{"name":"Sydney Medical School, The University of Sydney, New South Wales, Australia"},{"name":"Heart Research Institute, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Royal Prince Alfred Hospital, Sydney, New South Wales, Australia"},{"name":"Sydney Medical School, The University of Sydney, New South Wales, Australia"},{"name":"Heart Research Institute, Sydney, New South Wales, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,1,17]]},"reference":[{"key":"2021111618405840000_B1","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1161\/CIRCRESAHA.110.233403","article-title":"Leukocyte-derived microparticles in vascular homeostasis","volume":"110","author":"Angelillo-Scherrer","year":"2012","journal-title":"Circ. 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