{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,24]],"date-time":"2025-11-24T06:51:48Z","timestamp":1763967108492,"version":"3.41.2"},"reference-count":78,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":909,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,2,28]]},"abstract":"<jats:p>Asthma is a serious and hereditary respiratory disorder affecting all age groups. Interleukin-13 (IL-13) is a central regulator of allergic inflammation. The purpose of the present study was to estimate the relationship between IL-13 +1923C\/T polymorphism and asthma susceptibility. Relevant case-control studies published between January 2000 and July 2016 were searched in the online databases. Review Manage (RevMan) 5.3 was used to conduct the statistical analysis. The pooled odds ratio (OR) with its 95% confidence interval (CI) was employed to calculate the strength of association. A total of 26 articles were retrieved, including 17642 asthma patients and 42402 controls. Overall, our results found that IL-13 +1923C\/T polymorphism was significantly associated with increased risk of asthma under each genetic model (P&amp;lt;0.00001). Subgroup analysis by ethnicity showed that alleles and genotypes of this variant correlated with asthma among Asians and Caucasians, but only TT genotype under the homozygote model in Africans. When stratified by age group, this variant highly correlated with asthma in children and moderately in adults. Furthermore, the TT, CT and CC genotypes in asthma group were all significantly associated with increased IgE levels in sera of asthma patients when compared with controls. Our results suggested that IL-13 +1923C\/T polymorphism contributed to the development of asthma. Further case-control studies with more ethnicities are still needed.<\/jats:p>","DOI":"10.1042\/bsr20160505","type":"journal-article","created":{"date-parts":[[2017,1,6]],"date-time":"2017-01-06T02:30:34Z","timestamp":1483669834000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Association between IL-13 +1923C\/T polymorphism and asthma risk: a meta-analysis based on 26 case-control studies"],"prefix":"10.1042","volume":"37","author":[{"given":"Yueli","family":"Xu","sequence":"first","affiliation":[{"name":"Postgraduate Department of Internal Medicine, Weifang Medical University, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Junjuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Weifang People\u2019s Hospital, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaolei","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Weifang People\u2019s Hospital, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Weifang People\u2019s Hospital, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Weifang People\u2019s Hospital, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhengang","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Weifang People\u2019s Hospital, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine, Weifang People\u2019s Hospital, Weifang, Shandong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2017,1,27]]},"reference":[{"key":"2021111618404071900_B1","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1016\/S0140-6736(68)91043-X","article-title":"The definition of asthma","volume":"2","author":"Alpers","year":"1968","journal-title":"Lancet"},{"key":"2021111618404071900_B2","first-page":"1","article-title":"National surveillance of asthma: United States, 2001-2010","volume":"35","author":"Moorman","year":"2012","journal-title":"Vital Health Stat 3."},{"key":"2021111618404071900_B3","doi-asserted-by":"crossref","first-page":"935","DOI":"10.1378\/chest.100.4.935","article-title":"Characteristics of asthma among elderly adults in a sample of the general population","volume":"100","author":"Burrows","year":"1991","journal-title":"Chest"},{"key":"2021111618404071900_B4","first-page":"3602","article-title":"Global strategy for asthma management and prevention","author":"Global Initiative for Asthma","year":"2002","journal-title":"NIH Publication"},{"key":"2021111618404071900_B5","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1016\/S0140-6736(12)61728-0","article-title":"Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010","volume":"380","author":"Lozano","year":"2012","journal-title":"Lancet"},{"key":"2021111618404071900_B6","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(15)00156-7","article-title":"Risk factors for asthma: is prevention possible?","volume":"386","author":"Beasley","year":"2015","journal-title":"Lancet"},{"key":"2021111618404071900_B7","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1007\/s11882-012-0254-7","article-title":"Recent advances in the epidemiologic investigation of risk factors for asthma: a review of the 2011 literature","volume":"12","author":"Anto","year":"2012","journal-title":"Curr. 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