{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T19:39:13Z","timestamp":1790192353125,"version":"4.1.0"},"reference-count":29,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":850,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,4,30]]},"abstract":"<jats:p>The present study aims to explore the relationship between the Y chromosome polymorphisms (1qh+, inv(9), 9qh+, 16qh+, group D\/G, Yqh\u2013 and Yqh+) and the risk of unexplained recurrent miscarriage (URM). A total of 507 couples with URM were recruited as case group and 465 healthy couples as control group. The Y chromosome polymorphisms of the male individuals were analysed with the G-banding technique, and the results of the chromosome G-banding analysis were determined using the International Naming Standards of Human Genetics (ISCN). Logistic regression analysis was used to analyse the risk factors for URM. The detection rate of Y chromosome polymorphisms in the case group (12.03%) was higher than that in the control group (2.15%). Y chromosome polymorphisms were detected at significantly higher rates in the case group than in the control group. Using the normal Y chromosomes in individuals of the case group as reference, the partners of their counterparts were more likely to experience miscarriage. The couples who were Y chromosome-polymorphism carriers had shorter gestational age, increased frequency of URM and longer average interval between pregnancies. The results of logistic regression analysis revealed that Y chromosome polymorphisms, shorter gestational age, a higher frequency of miscarriage and longer pregnancy interval were independent risk factors for URM. Y chromosome polymorphisms may be associated with the risk of URM and may play an important role in the development of URM.<\/jats:p>","DOI":"10.1042\/bsr20160528","type":"journal-article","created":{"date-parts":[[2017,2,10]],"date-time":"2017-02-10T01:40:15Z","timestamp":1486690815000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Y chromosome polymorphisms may contribute to an increased risk of male-induced unexplained recurrent miscarriage"],"prefix":"10.1042","volume":"37","author":[{"given":"Yan","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Gynecology and Obstetrics, The People\u2019s Hospital of Three Gorges University, The First People\u2019s Hospital of Yichang, Yichang 443000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gang","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The People\u2019s Hospital of Three Gorges University, The First People\u2019s Hospital of Yichang, Yichang 443000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man-Zhen","family":"Zuo","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, The People\u2019s Hospital of Three Gorges University, The First People\u2019s Hospital of Yichang, Yichang 443000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-Hua","family":"Fang","sequence":"additional","affiliation":[{"name":"Radiology Department, Traditional Chinese Medicine Hospital of Zhijiang, Yichang, 443000, P. R. 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China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ping-Ping","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, The People\u2019s Hospital of Three Gorges University, The First People\u2019s Hospital of Yichang, Yichang 443000, P. R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,3,27]]},"reference":[{"key":"2021111619093628200_B1","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1159\/000365973","article-title":"Recurrent spontaneous miscarriage is still a challenging diagnostic and therapeutic quagmire","volume":"24","author":"Diejomaoh","year":"2015","journal-title":"Med. Princ. Pract."},{"key":"2021111619093628200_B2","doi-asserted-by":"crossref","first-page":"1740","DOI":"10.1056\/NEJMcp1005330","article-title":"Clinical practice. Recurrent miscarriage","volume":"363","author":"Branch","year":"2010","journal-title":"N. Engl. J. 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