{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T15:05:48Z","timestamp":1774623948075,"version":"3.50.1"},"reference-count":36,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":743,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,8,31]]},"abstract":"<jats:p>The present study aims to explore the role of stromal cell-derived factor-1\u03b1 (SDF-1\u03b1)\/stromal cell-derived factor receptor-4 (CXCR4) signaling pathway to the clinicopathological features and prognosis of patients with nasopharyngeal carcinoma (NPC). From January 2009 to December 2010, 102 patients with NPC and 80 patients with chronic nasopharyngitis were enrolled for the study. Immunohistochemical staining, quantitative real-time polymerase chain reaction (qRT-PCR), and Western blotting were employed to determine the expressions of SDF-1\u03b1 and CXCR4 proteins in NPC tissues and chronic nasopharyngitis tissues. Chi-square test was conducted to analyze the associations of the expressions of SDF-1\u03b1 and CXCR4 proteins with the clinicopathological features of NPC patients. Spearman rank correlation analysis was used to analyze the correlation between the SDF-1\u03b1 protein expression and CXCR4 protein expression. The mRNA and protein expressions of SDF-1\u03b1 and CXCR4 in NPC tissues were significantly higher than those in chronic nasopharyngitis tissues. The expressions of SDF-1\u03b1 and CXCR4 proteins showed associations with T staging, N staging, tumor node metastasis (TNM) staging, skull base invasion, and cervical lymph node metastasis of NPC patients. Compared with NPC patients showing negative expressions of SDF-1\u03b1 and CXCR4 proteins, those with positive expressions of SDF-1\u03b1 and CXCR4 proteins had a significantly shorter survival time. SDF-1\u03b1 protein, CXCR4 protein, EBV-IgG status, T staging, N staging, TNM staging, skull base invasion, and cervical lymph node metastasis were independent risk factors for the prognosis of NPC. The findings indicated that SDF-1\u03b1\/CXCR4 signaling pathway might be associated with the clinicopathological features and prognosis of patients with NPC.<\/jats:p>","DOI":"10.1042\/bsr20170144","type":"journal-article","created":{"date-parts":[[2017,5,31]],"date-time":"2017-05-31T00:25:34Z","timestamp":1496190334000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Role of SDF-1\u03b1\/CXCR4 signaling pathway in clinicopathological features and prognosis of patients with nasopharyngeal carcinoma"],"prefix":"10.1042","volume":"37","author":[{"given":"Yun-Ling","family":"Li","sequence":"first","affiliation":[{"name":"Department of ENT, Linyi People\u2019s Hospital, Linyi City 276003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu-Fen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of ENT, Linyi People\u2019s Hospital, Linyi City 276003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua-Feng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetic Laboratory, Women and Children\u2019s Hospital of Linyi, Linyi City 276016, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huai-Qing","family":"Lv","sequence":"additional","affiliation":[{"name":"Department of ENT, Linyi People\u2019s Hospital, Linyi City 276003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"De-Zhong","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of ENT, Linyi People\u2019s Hospital, Linyi City 276003, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2017,7,12]]},"reference":[{"key":"2021111618523250300_B1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1476-4598-6-1","article-title":"Nasopharyngeal carcinoma: molecular biomarker discovery and progress","volume":"6","author":"Cho","year":"2007","journal-title":"Mol. Cancer"},{"key":"2021111618523250300_B2","first-page":"495","article-title":"Identification of Galectin-1 as a novel biomarker in nasopharyngeal carcinoma by proteomic analysis","volume":"24","author":"Tang","year":"2010","journal-title":"Oncol. Rep."},{"key":"2021111618523250300_B3","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.semcancer.2012.01.007","article-title":"Genetic predisposition factors and nasopharyngeal carcinoma risk: a review of epidemiological association studies, 2000-2011: Rosetta Stone for NPC: genetics, viral infection, and other environmental factors","volume":"22","author":"Hildesheim","year":"2012","journal-title":"Semin. Cancer Biol."},{"key":"2021111618523250300_B4","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1002\/ijc.28683","article-title":"Improving the TNM classification: findings from a 10-year continuous literature review","volume":"135","author":"Webber","year":"2014","journal-title":"Int. J. Cancer"},{"key":"2021111618523250300_B5","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1471-2407-12-98","article-title":"Patterns of regional lymph node metastasis of nasopharyngeal carcinoma: a meta-analysis of clinical evidence","volume":"12","author":"Ho","year":"2012","journal-title":"BMC Cancer"},{"key":"2021111618523250300_B6","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1007\/s00066-014-0656-7","article-title":"MRI-detected skull-base invasion: prognostic value and therapeutic implication in intensity-modulated radiotherapy treatment for nasopharyngeal carcinoma","volume":"190","author":"Cheng","year":"2014","journal-title":"Strahlenther. Onkol."},{"key":"2021111618523250300_B7","doi-asserted-by":"crossref","first-page":"551","DOI":"10.5732\/cjc.009.10518","article-title":"Neoadjuvant chemotherapy followed by concurrent chemoradiation for locally advanced nasopharyngeal carcinoma","volume":"29","author":"Kong","year":"2010","journal-title":"Chin. J. Cancer"},{"key":"2021111618523250300_B8","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1002\/ijc.24040","article-title":"CXCL8\/IL-8 and CXCL12\/SDF-1alpha co-operatively promote invasiveness and angiogenesis in pancreatic cancer","volume":"124","author":"Matsuo","year":"2009","journal-title":"Int. J. Cancer"},{"key":"2021111618523250300_B9","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/ijc.23083","article-title":"Involvement of SDF-1alpha\/CXCR4 axis in the enhanced peritoneal metastasis of epithelial ovarian carcinoma","volume":"122","author":"Kajiyama","year":"2008","journal-title":"Int. J. Cancer"},{"key":"2021111618523250300_B10","doi-asserted-by":"crossref","first-page":"1066","DOI":"10.1126\/science.1194396","article-title":"Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists","volume":"330","author":"Wu","year":"2010","journal-title":"Science"},{"key":"2021111618523250300_B11","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1084\/jem.20072513","article-title":"CXCR4 is required for the quiescence of primitive hematopoietic cells","volume":"205","author":"Nie","year":"2008","journal-title":"J. Exp. Med."},{"key":"2021111618523250300_B12","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13045-015-0231-4","article-title":"Cancer-associated fibroblasts promote the progression of endometrial cancer via the SDF-1\/CXCR4 axis","volume":"9","author":"Teng","year":"2016","journal-title":"J. Hematol. Oncol."},{"key":"2021111618523250300_B13","first-page":"6606","article-title":"Expression of SNCG, MAP2, SDF-1 and CXCR4 in gastric adenocarcinoma and their clinical significance","volume":"7","author":"Zheng","year":"2014","journal-title":"Int. J. Clin. Exp. Pathol."},{"key":"2021111618523250300_B14","doi-asserted-by":"crossref","first-page":"650","DOI":"10.2471\/BLT.08.050955","article-title":"The Declaration of Helsinki and public health","volume":"86","author":"Williams","year":"2008","journal-title":"Bull. World Health Organ."},{"key":"2021111618523250300_B15","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.oraloncology.2014.10.012","article-title":"Impact of intensity-modulated radiotherapy on nasopharyngeal carcinoma: Validation of the 7th edition AJCC staging system","volume":"51","author":"Zong","year":"2015","journal-title":"Oral Oncol."},{"key":"2021111618523250300_B16","doi-asserted-by":"publisher","first-page":"733","DOI":"10.1007\/s10549-009-0672-y","article-title":"Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis.","volume":"123","author":"Kobayashi","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"2021111618523250300_B17","doi-asserted-by":"publisher","first-page":"23552","DOI":"10.18632\/oncotarget.8083","article-title":"Kr\u00fcppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis.","volume":"7","author":"Mukherjee","year":"2016","journal-title":"Oncotarget"},{"key":"2021111618523250300_B18","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1007\/s10549-009-0672-y","article-title":"Expression pattern of stromal cell-derived factor-1 chemokine in invasive breast cancer is correlated with estrogen receptor status and patient prognosis","volume":"123","author":"Kobayashi","year":"2010","journal-title":"Breast Cancer Res. Treat."},{"key":"2021111618523250300_B19","doi-asserted-by":"crossref","first-page":"23552","DOI":"10.18632\/oncotarget.8083","article-title":"Kruppel-like factor 8 activates the transcription of C-X-C cytokine receptor type 4 to promote breast cancer cell invasion, transendothelial migration and metastasis","volume":"7","author":"Mukherjee","year":"2016","journal-title":"Oncotarget"},{"key":"2021111618523250300_B20","first-page":"917","article-title":"Clinicopathological significance of MMP-2 and its specific inhibitor TIMP-2 in gastric cancer","volume":"23","author":"Alakus","year":"2008","journal-title":"Histol. Histopathol."},{"key":"2021111618523250300_B21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1002\/cncr.23555","article-title":"Retropharyngeal lymph node metastasis in nasopharyngeal carcinoma detected by magnetic resonance imaging: prognostic value and staging categories","volume":"113","author":"Tang","year":"2008","journal-title":"Cancer"},{"key":"2021111618523250300_B22","doi-asserted-by":"crossref","first-page":"2708","DOI":"10.1182\/blood-2006-07-035857","article-title":"Mechanisms of regulation of CXCR4\/SDF-1 (CXCL12)-dependent migration and homing in multiple myeloma","volume":"109","author":"Alsayed","year":"2007","journal-title":"Blood"},{"key":"2021111618523250300_B23","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1002\/jcp.21266","article-title":"Functional interleukin-7\/interleukin-7Ralpha, and SDF-1alpha\/CXCR4 are expressed by human periodontal ligament derived mesenchymal stem cells","volume":"214","author":"Trubiani","year":"2008","journal-title":"J. Cell. Physiol."},{"key":"2021111618523250300_B24","doi-asserted-by":"crossref","first-page":"2927","DOI":"10.1158\/1078-0432.CCR-09-2329","article-title":"CXCL12 (SDF-1)\/CXCR4 pathway in cancer","volume":"16","author":"Teicher","year":"2010","journal-title":"Clin. Cancer Res."},{"key":"2021111618523250300_B25","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/B978-0-12-411638-2.00002-1","article-title":"The intricate role of CXCR4 in cancer","volume":"124","author":"Chatterjee","year":"2014","journal-title":"Adv. Cancer Res."},{"key":"2021111618523250300_B26","doi-asserted-by":"crossref","first-page":"471","DOI":"10.1158\/0008-5472.CAN-09-2863","article-title":"Characterization of phosphoglycerate kinase-1 expression of stromal cells derived from tumor microenvironment in prostate cancer progression","volume":"70","author":"Wang","year":"2010","journal-title":"Cancer Res."},{"key":"2021111618523250300_B27","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/1479-5876-11-203","article-title":"The independent, unfavorable prognostic factors endothelin A receptor and chemokine receptor 4 have a close relationship in promoting the motility of nasopharyngeal carcinoma cells via the activation of AKT and MAPK pathways","volume":"11","author":"Luo","year":"2013","journal-title":"J. Transl. Med."},{"key":"2021111618523250300_B28","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1089\/scd.2012.0717","article-title":"Low-level shear stress induces human mesenchymal stem cell migration through the SDF-1\/CXCR4 axis via MAPK signaling pathways","volume":"22","author":"Yuan","year":"2013","journal-title":"Stem Cells Dev."},{"key":"2021111618523250300_B29","first-page":"507353","article-title":"Relationships of alpha-SMA-positive fibroblasts and SDF-1-positive tumor cells with neoangiogenesis in nasopharyngeal carcinoma","volume":"2014","author":"Wang","year":"2014","journal-title":"Biomed. Res. Int."},{"key":"2021111618523250300_B30","first-page":"260","article-title":"Association of CXCR4 and SDF-1alpha with organ-specific metastasis of nasopharyngeal carcinoma","volume":"31","author":"Luo","year":"2009","journal-title":"Zhonghua Zhong Liu Za Zhi"},{"key":"2021111618523250300_B31","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.meegid.2014.04.018","article-title":"CXCR4: a virus\u2019s best friend?","volume":"25","author":"Arnolds","year":"2014","journal-title":"Infect. Genet. Evol."},{"key":"2021111618523250300_B32","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.it.2007.05.007","article-title":"The SDF-1-CXCR4 signaling pathway: a molecular hub modulating neo-angiogenesis","volume":"28","author":"Petit","year":"2007","journal-title":"Trends Immunol."},{"key":"2021111618523250300_B33","first-page":"1197","article-title":"Close correlation between CXCR4 and VEGF expression and their prognostic implications in nasopharyngeal carcinoma","volume":"21","author":"Segawa","year":"2009","journal-title":"Oncol. Rep."},{"key":"2021111618523250300_B34","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1158\/0008-5472.CAN-06-2971","article-title":"A glycolytic mechanism regulating an angiogenic switch in prostate cancer","volume":"67","author":"Wang","year":"2007","journal-title":"Cancer. Res."},{"key":"2021111618523250300_B35","first-page":"2835","article-title":"CXCL12 genetic variants as prognostic markers in nasopharyngeal carcinoma","volume":"8","author":"Chen","year":"2015","journal-title":"Onco. Targets Ther."},{"key":"2021111618523250300_B36","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/1479-5876-3-26","article-title":"Expression of chemokine receptor CXCR4 in nasopharyngeal carcinoma: pattern of expression and correlation with clinical outcome","volume":"3","author":"Wang","year":"2005","journal-title":"J. Transl. Med."}],"updated-by":[{"DOI":"10.1042\/bsr-2017-0144_ret","type":"retraction","label":"Retraction","source":"retraction-watch","updated":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000},"record-id":"66514"},{"DOI":"10.1042\/bsr-2017-0144_ret","type":"retraction","label":"Retraction","source":"publisher","updated":{"date-parts":[[2024,4,24]],"date-time":"2024-04-24T00:00:00Z","timestamp":1713916800000}}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20170144\/480742\/bsr-2017-0144.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20170144\/480742\/bsr-2017-0144.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T19:31:21Z","timestamp":1637091081000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/37\/4\/BSR20170144\/57335\/Role-of-SDF-1-CXCR4-signaling-pathway-in"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,7,12]]},"references-count":36,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2017,8,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20170144","relation":{"retraction":[{"id-type":"doi","id":"10.1042\/BSR-2017-0144_RET","asserted-by":"object"}]},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,7,12]]},"article-number":"BSR20170144"}}