{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T03:02:10Z","timestamp":1781665330557,"version":"3.54.5"},"reference-count":23,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":646,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2017,10,31]]},"abstract":"<jats:p>Osteoarthritis (OA) is a complex disease that is induced by many genetic risk variants and other factors. To examine the role of toll-like receptor 9 (TLR-9) in OA patients, we conducted a case\u2013control study involving 215 knee OA (KOA) patients and 215 controls in a Chinese population. Genotyping with a custom-by-design 48-Plex single nucleotide polymorphism Scan\u2122 Kit showed the TLR-9 gene rs187084 polymorphism was associated with an increased risk of KOA. Stratification analyses further validated this finding among old people (age \u2265 55 years). In conclusion, TLR-9 gene rs187084 polymorphism is positively correlated with susceptibility to KOA, especially among old people. Nevertheless, this finding should be confirmed by larger size studies with more ethnic populations.<\/jats:p>","DOI":"10.1042\/bsr20170844","type":"journal-article","created":{"date-parts":[[2017,9,16]],"date-time":"2017-09-16T00:40:21Z","timestamp":1505522421000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Association between <i>TLR<\/i>-9 gene rs187084 polymorphism and knee osteoarthritis in a Chinese population"],"prefix":"10.1042","volume":"37","author":[{"given":"Mingfeng","family":"Zheng","sequence":"first","affiliation":[{"name":"Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiyuan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozhang","family":"Ying","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanghui","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Hangzhou Red Cross Hospital (Zhejiang Chinese Medicine Integrated Hospital), 208 Huanchengdong Road, Hangzhou, Zhejiang 310003, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2017,10,17]]},"reference":[{"key":"2021111618451829800_B1","doi-asserted-by":"crossref","first-page":"958","DOI":"10.1136\/ard.48.11.958","article-title":"Osteoarthritis: the cause not result of joint failure?","volume":"48","author":"Hutton","year":"1989","journal-title":"Ann. 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