{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T02:23:37Z","timestamp":1771467817173,"version":"3.50.1"},"reference-count":15,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":552,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:p>Purpose: To report successful treatment with transluminal Nd:YAG laser embolysis (TYE) combined with urokinase thrombolysis for reperfusion of occluded branch retinal arteries with visible emboli.<\/jats:p>\n               <jats:p>Methods: A total of 34 eyes from 34 patients with acute, severe vision loss secondary to a branch retinal artery occlusion with visible emboli and retinal whitening were examined. Each patient was administered TYE therapy, which focused on the embolus, using an ocular contact lens; a 0.3\u20130.9 mJ laser pulse was delivered directly and gradually according to the reaction. Fundus photographs and fundus fluorescein angiography (FFA) were obtained before and immediately after the laser treatment. All patients received urokinase thrombolysis therapy drops intravenously for 5 days at 10\u201320 u\/d. The follow-up period ranged from 6 to 14 months after therapy. The morphological characteristics of FFA associated with obstruction recovery of arterial fluorescence filling and visual function were analyzed.<\/jats:p>\n               <jats:p>Results: After TYE therapy, FFA examinations showed that the retinal artery and its branches exhibited completely restored blood flow without obstruction in 13 eyes, accounting for 38.2% of the cases. The blood flow was mostly recovered in 11 eyes (32.4% of patients). FFA examinations following the combined intravenous urokinase thrombolysis therapy showed that the retinal artery and its branches exhibited completely restored blood flow after obstruction in 16 eyes (47.1% of patients). The blood flow was mostly recovered in 15 eyes (44.1% of patients).<\/jats:p>\n               <jats:p>Conclusion: TYE combined with urokinase thrombolysis is effective for reperfusion of occluded branch retinal arteries and improving visual recovery in patients with visible emboli.<\/jats:p>","DOI":"10.1042\/bsr20170930","type":"journal-article","created":{"date-parts":[[2017,11,22]],"date-time":"2017-11-22T01:10:39Z","timestamp":1511313039000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Reperfusion of occluded branch retinal arteries by transluminal Nd:YAG laser embolysis combined with intravenous thrombolysis of urokinase"],"prefix":"10.1042","volume":"38","author":[{"given":"Fang","family":"Chai","sequence":"first","affiliation":[{"name":"Shanxi Ophthalmic Medical Center, Xi\u2019an No. 4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shanshuang","family":"Du","sequence":"additional","affiliation":[{"name":"Shanxi Ophthalmic Medical Center, Xi\u2019an No. 4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiquan","family":"Zhao","sequence":"additional","affiliation":[{"name":"Shanxi Ophthalmic Medical Center, Xi\u2019an No. 4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Runsheng","family":"Wang","sequence":"additional","affiliation":[{"name":"Shanxi Ophthalmic Medical Center, Xi\u2019an No. 4 Hospital, Affiliated Guangren Hospital, School of Medicine, Xi\u2019an Jiaotong University, Xi\u2019an 710004, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,1,19]]},"reference":[{"key":"2021111618464615900_B1","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1038\/eye.2013.25","article-title":"A review of central retinal artery occlusion: clinical presentation and management","volume":"27","author":"Varma","year":"2013","journal-title":"Eye"},{"key":"2021111618464615900_B2","doi-asserted-by":"publisher","first-page":"E7","DOI":"10.3171\/2013.11.FOCUS13331","article-title":"Current endovascular treatment options for central retinal arterial occlusion: a review","volume":"36","author":"Agarwal","year":"2014","journal-title":"Neurosurg. 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Sci."},{"key":"2021111618464615900_B11","first-page":"1","article-title":"Urokinase, a promising candidate for fibrinolytic therapy for intracerebral hemorrhage","volume":"22","author":"Tan","year":"2016","journal-title":"J. Neurosurg."},{"key":"2021111618464615900_B12","doi-asserted-by":"publisher","first-page":"4593","DOI":"10.3892\/mmr.2016.5146","article-title":"Thrombosis recanalization by paeoniflorin through the upregulation of urokinase type plasminogen activator via the MAPK signaling pathway","volume":"13","author":"Ye","year":"2016","journal-title":"Mol. Med. Rep."},{"key":"2021111618464615900_B13","doi-asserted-by":"publisher","first-page":"455","DOI":"10.1016\/j.ajo.2008.05.009","article-title":"Branch retinal artery occlusion: visual prognosis","volume":"146","author":"Mason","year":"2008","journal-title":"Am. J. 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Pregl."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20170930\/429344\/bsr-2017-0930-t.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20170930\/429344\/bsr-2017-0930-t.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T19:17:42Z","timestamp":1637090262000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/38\/1\/BSR20170930\/57022\/Reperfusion-of-occluded-branch-retinal-arteries-by"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,1,19]]},"references-count":15,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2018,2,28]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20170930","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,19]]},"article-number":"BSR20170930"}}