{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:05:44Z","timestamp":1787011544354,"version":"build-2736575974"},"reference-count":41,"publisher":"Portland Press Ltd.","issue":"4","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":359,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,8,31]]},"abstract":"<jats:p>Background: Periodontitis is a very common inflammatory oral disease. Tumor necrosis factor-\u03b1 (TNF-\u03b1) is a cytokine that has been involved with the gingival tissue destruction and remodeling occurrence. We investigated the association of single nucleotide polymorphisms (SNPs) in TNF-\u03b1 gene promoter region with the susceptibility of aggressive and chronic periodontitis in the eastern Indian population.<\/jats:p>\n               <jats:p>Methods: A total of 397 DNA samples from venous blood were isolated. 40 individuals were aggressive periodontitis patients, 157 were identified chronic periodontitis patients, and the remaining 200 were healthy individuals. Five SNPs of TNF-\u03b1 at promoter region (rs361525, rs1800629, rs1799724, rs1800630, and rs1799964) were genotyped by PCR-sequencing in periodontitis patients and control subjects.<\/jats:p>\n               <jats:p>Results: rs1800629 (-308G\/A) polymorphism was more frequent in both aggressive and chronic periodontitis patients compared with the control population, though the allele frequency was different only in aggressive periodontitis patients. On the other hand, both the genotypic and allelic variation of rs361525 (-238G\/A) polymorphism were found significantly less frequently in aggressive and chronic periodontitis than in controls. The other polymorphisms like rs1799724 (-857C\/T) and rs1799964 (-1031T\/C) were significantly different between chronic periodontitis patients and control subjects.<\/jats:p>\n               <jats:p>Conclusion: The findings suggest that the rs1800629 (-308G\/A) polymorphism of TNF-\u03b1 gene is associated with both aggressive and chronic periodontitis while rs1799724 (-857C\/T) and rs1799964 (-1031T\/C) polymorphisms of TNF-\u03b1 gene is associated only with the increased susceptibility to chronic periodontitis.<\/jats:p>","DOI":"10.1042\/bsr20171212","type":"journal-article","created":{"date-parts":[[2018,2,16]],"date-time":"2018-02-16T01:20:20Z","timestamp":1518744020000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Association of tumor necrosis factor-\u03b1 (TNF-\u03b1) gene promoter polymorphisms with aggressive and chronic periodontitis in the eastern Indian population"],"prefix":"10.1042","volume":"38","author":[{"given":"Poulami","family":"Majumder","sequence":"first","affiliation":[{"name":"Department of Biotechnology, Centre for Genetic studies, School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, Salt Lake City, Kolkata, West Bengal 70064, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keheibamding","family":"Thou","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Centre for Genetic studies, School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, Salt Lake City, Kolkata, West Bengal 70064, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mandar","family":"Bhattacharya","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Centre for Genetic studies, School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, Salt Lake City, Kolkata, West Bengal 70064, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vineet","family":"Nair","sequence":"additional","affiliation":[{"name":"Department of Periodontia, North Bengal Dental College, Siliguri, West Bengal, 734012, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sujay","family":"Ghosh","sequence":"additional","affiliation":[{"name":"Department of Zoology, Cytogenetics and Genomics Research Unit, University of Calcutta, 35 Ballygunge Circular Road, Kolkata, West Bengal 700019, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Subrata\u00a0Kumar","family":"Dey","sequence":"additional","affiliation":[{"name":"Department of Biotechnology, Centre for Genetic studies, School of Biotechnology and Biological Sciences, West Bengal University of Technology, BF-142, Sector I, Salt Lake City, Kolkata, West Bengal 70064, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,7,31]]},"reference":[{"key":"2021111618592706700_B1","doi-asserted-by":"publisher","first-page":"1809","DOI":"10.1016\/S0140-6736(05)67728-8","article-title":"Periodontal diseases","volume":"366","author":"Pihlstrom","year":"2005","journal-title":"Lancet"},{"key":"2021111618592706700_B2","doi-asserted-by":"publisher","first-page":"977","DOI":"10.1111\/jcpe.12154","article-title":"Genome-wide association study of chronic periodontitis in general German population","volume":"40","author":"Teumer","year":"2013","journal-title":"J. Clin. Periodontol."},{"key":"2021111618592706700_B3","doi-asserted-by":"publisher","first-page":"821","DOI":"10.1902\/annals.1996.1.1.821","article-title":"Periodontal diseases: pathogensis","volume":"1","author":"Offenbacher","year":"1996","journal-title":"Ann. Periodontol."},{"key":"2021111618592706700_B4","doi-asserted-by":"publisher","first-page":"524","DOI":"10.1034\/j.1600-051X.2003.00287.x","article-title":"Tumor necrosis factor-alpha gene (TNF-alpha) -1031\/-863, -857 single-nucleotide polymorphisms (SNPs) are associated with severe adult periodontitis in Japanese","volume":"30","author":"Soga","year":"2003","journal-title":"J. Clin. Periodontol."},{"key":"2021111618592706700_B5","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1902\/annals.1999.4.1.1","article-title":"Development of a classification system for periodontal diseases and conditions","volume":"4","author":"Armitage","year":"1999","journal-title":"Ann. Periodontol."},{"key":"2021111618592706700_B6","doi-asserted-by":"publisher","first-page":"1554","DOI":"10.1902\/jop.2001.72.11.1554","article-title":"Analysis of single nucleotide polymorphisms in the 5\u2032-flanking region of tumor necrosis factor-\u03b1 gene in Japanese patients with early-onset periodontitis","volume":"72","author":"Endo","year":"2001","journal-title":"J. Periodontol."},{"key":"2021111618592706700_B7","doi-asserted-by":"publisher","first-page":"391","DOI":"10.1016\/S0161-5890(97)00052-7","article-title":"The-308 tumor necrosis factor- \u03b1 promoter polymorphism effects transcription","volume":"34","author":"Kroeger","year":"1997","journal-title":"Mol. Immunol."},{"key":"2021111618592706700_B8","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1038\/gene.2011.28","article-title":"Gene\u2013gene interaction among cytokine polymorphisms influence susceptibility to aggressive periodontitis","volume":"12","author":"Scapoli","year":"2011","journal-title":"Genes Immun."},{"key":"2021111618592706700_B9","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1177\/0022034512465435","article-title":"Modeling susceptibility to periodontitis","volume":"92","author":"Laine","year":"2013","journal-title":"J. Dent. Res."},{"key":"2021111618592706700_B10","doi-asserted-by":"publisher","first-page":"1444","DOI":"10.1097\/00007890-200110270-00019","article-title":"Association of cytokine polymorphic inheritance and in vitro cytokine production in anti-CD3\/CD28-stimulated peripheral blood lymphocytes","volume":"72","author":"Hoffmann","year":"2001","journal-title":"Transplantation"},{"key":"2021111618592706700_B11","volume-title":"Tumor Necrosis Factor","author":"Tracey","year":"1997"},{"key":"2021111618592706700_B12","doi-asserted-by":"publisher","first-page":"557","DOI":"10.1016\/j.copbio.2004.09.005","article-title":"Tumour necrosis factor alpha as a therapeutic target for immune-mediated inflammatory diseases","volume":"15","author":"Taylor","year":"2004","journal-title":"Curr. Opin. Biotechnol."},{"key":"2021111618592706700_B13","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1038\/337661a0","article-title":"Prolonged activation of jun and collagenase genes by tumour necrosis-\u03b1","volume":"337","author":"Brenner","year":"1989","journal-title":"Nature"},{"key":"2021111618592706700_B14","doi-asserted-by":"publisher","first-page":"19099","DOI":"10.1038\/srep19099","article-title":"Tumor necrosis factor-\u03b1 G-308A(rs1800629) polymorphism and aggressive periodontitis susceptibility: a meta-analysis of 16 case-control studies","volume":"6","author":"Wei","year":"2016","journal-title":"Sci. Rep."},{"key":"2021111618592706700_B15","first-page":"1180e8","article-title":"An analysis of linkage disequilibrium in the interleukin-1 gene cluster, using a novel grouping method for multiple markers","volume":"82","author":"Cox","year":"1998","journal-title":"Am. J. Hum. Genet."},{"key":"2021111618592706700_B16","doi-asserted-by":"publisher","first-page":"1699","DOI":"10.1902\/jop.2000.71.11.1699","article-title":"Evidence of a substantial genetic basis for risk of adult periodontitis","volume":"71","author":"Michalowicz","year":"2000","journal-title":"J. Periodontol."},{"key":"2021111618592706700_B17","doi-asserted-by":"publisher","first-page":"1149","DOI":"10.1177\/154405910508401211","article-title":"Functional gene polymorphisms in aggressive and chronic periodontitis","volume":"84","author":"Brett","year":"2005","journal-title":"J. Dent. Res."},{"key":"2021111618592706700_B18","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1111\/j.1600-051X.2006.00983.x","article-title":"No correlation of five gene polymorphisms with periodontal conditions in a Greek population","volume":"33","author":"Sakellari","year":"2006","journal-title":"J. Clin. Periodontol."},{"key":"2021111618592706700_B19","first-page":"268","article-title":"Relationship between tumor necrosis factor A-308 gene polymorphism and aggressive periodontitis","volume":"42","author":"Zhu","year":"2007","journal-title":"Zhonghua Kou Qiang Yi Xue Za Zhi"},{"key":"2021111618592706700_B20","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1590\/S1806-83242008000400007","article-title":"Lack of association between the TNF-alpha -308 (G\/A) genetic polymorphism and periodontal disease in Brazilians","volume":"22","author":"Menezes","year":"2008","journal-title":"Braz. Oral. Res."},{"key":"2021111618592706700_B21","doi-asserted-by":"publisher","first-page":"333","DOI":"10.1111\/adj.12087","article-title":"Correlation between the severity of periodontitis and coronary artery stenosis in a Chinese population","volume":"58","author":"Yang","year":"2013","journal-title":"Aust. Dent. J."},{"key":"2021111618592706700_B22","first-page":"63","article-title":"Lack of association between the TNF-\u03b1-1031 genotypes and generalized aggressive periodontitis disease","volume":"62","author":"Darvishi","year":"2016","journal-title":"Cell. Mol. Biol."},{"key":"2021111618592706700_B23","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1111\/j.1600-0757.2011.00415.x","article-title":"Genetic susceptibility to periodontitis","volume":"58","author":"Laine","year":"2012","journal-title":"Periodontol 2000"},{"key":"2021111618592706700_B24","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1902\/jop.1998.69.4.428","article-title":"Tumor necrosis factor \u03b1 production by oral leukocytes: influence of tumor necrosis factor genotype","volume":"69","author":"Galbraith","year":"1998","journal-title":"J. Periodontol."},{"key":"2021111618592706700_B25","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1034\/j.1600-051X.1999.t01-1-261101.x","article-title":"Polymorphic cytokine genotypes as markers of disease severity in adult periodontitis","volume":"26","author":"Galbraith","year":"1999","journal-title":"J. Clin. Periodontol."},{"key":"2021111618592706700_B26","doi-asserted-by":"publisher","first-page":"22","DOI":"10.1155\/2010\/324719","article-title":"Gene polymorphisms in chronic periodontitis","volume":"2010","author":"Laine","year":"2010","journal-title":"Int. J. Dentistry"},{"key":"2021111618592706700_B27","doi-asserted-by":"publisher","first-page":"88","DOI":"10.1016\/j.mgene.2017.02.002","article-title":"Alliance of matrix metalloproteinase-9 (MMP-9) promoter gene polymorphism with chronic and aggressive periodontitis in Indian population","volume":"12","author":"Majumder","year":"2017","journal-title":"Meta Gene"},{"key":"2021111618592706700_B28","first-page":"154","article-title":"MMP-1 promoter polymorphism: association with chronic periodontitis severity in a Brazilian population","volume":"30","author":"De Souza","year":"2003"},{"key":"2021111618592706700_B29","doi-asserted-by":"publisher","first-page":"32","DOI":"10.1902\/annals.1999.4.1.32","article-title":"Periodontitis","volume":"4","author":"Flemmig","year":"1999","journal-title":"Ann. Periodontol."},{"key":"2021111618592706700_B30","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1006\/cyto.1999.0529","article-title":"Effects of stimulus and cell type on the expression of the -308 tumour necrosis factor promoter polymorphism","volume":"12","author":"Kroeger","year":"2000","journal-title":"Cytokine"},{"key":"2021111618592706700_B31","doi-asserted-by":"publisher","first-page":"500","DOI":"10.1111\/j.1600-0765.1993.tb02113.x","article-title":"Role of cytokines and inflammatory mediators in tissue destruction","volume":"28","author":"Birkedal-Hansen","year":"1993","journal-title":"J. Periodontal Res."},{"key":"2021111618592706700_B32","doi-asserted-by":"publisher","first-page":"566","DOI":"10.1111\/j.1600-0765.1993.tb02126.x","article-title":"Regulation of differentiation of gingival fibroblasts and periodontal ligament cells by rhIL-1b and rhTNF-a","volume":"28","author":"Dufour","year":"1993","journal-title":"J. Periodontal Res."},{"key":"2021111618592706700_B33","doi-asserted-by":"publisher","first-page":"63S","DOI":"10.1016\/8756-3282(95)00180-L","article-title":"Role of cytokines in bone resorption","volume":"17","author":"Manolagas","year":"1995","journal-title":"Bone"},{"key":"2021111618592706700_B34","doi-asserted-by":"publisher","first-page":"599","DOI":"10.1111\/j.1365-3083.1988.tb01492.x","article-title":"Association between HLA-DR2 and production of tumour necrosis factor a and interleukin 1 by mononuclear cells activated by lipopolysaccharide","volume":"28","author":"Bendtzen","year":"1988","journal-title":"Scand. J. Immunol."},{"key":"2021111618592706700_B35","doi-asserted-by":"publisher","first-page":"224","DOI":"10.1002\/eji.1830230135","article-title":"Association of tumor necrosis factor (TNF) and class II major histo compatibility complex alleles with the secretion of TNF-\u03b1 and TNF-beta by human mononuclear cells: a possible link to insulin- dependent diabetes mellitus","volume":"23","author":"Pociot","year":"1993","journal-title":"Eur. J. Immunol."},{"key":"2021111618592706700_B36","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1016\/S0140-6736(96)06413-6","article-title":"Genetic influence on cytokine production and fatal meningococcal disease","volume":"349","author":"Westendorp","year":"1997","journal-title":"Lancet"},{"key":"2021111618592706700_B37","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1007\/BF03401767","article-title":"Functional analysis of a human tumor necrosis \u03b1 (TNF-\u03b1) promoter polymorphism related to joint damage in rheumatoid arthritis","volume":"4","author":"Kaijzel","year":"1998","journal-title":"Mol. Med."},{"key":"2021111618592706700_B38","doi-asserted-by":"publisher","first-page":"3195","DOI":"10.1073\/pnas.94.7.3195","article-title":"Effects of a polymorphism in the human tumor necrosis factor \u03b1 promoter on transcriptional activation","volume":"94","author":"Wilson","year":"1997","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111618592706700_B39","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1046\/j.1365-2249.1998.00662.x","article-title":"Tumour necrosis factor (TNF) gene polymorphism influences TNF-\u03b1 production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans","volume":"113","author":"Louis","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"2021111618592706700_B40","doi-asserted-by":"publisher","first-page":"631","DOI":"10.1089\/jir.1997.17.631","article-title":"DNA polymorphisms and mutations of the tumor necrosis factor-\u03b1 (TNF-\u03b1) promoter in Langerhans cell histiocytosis (LCH)","volume":"17","author":"Wu","year":"1997","journal-title":"J. Interferon Cytokine Res."},{"key":"2021111618592706700_B41","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1111\/j.1600-0757.1997.tb00194.x","article-title":"Cytokines and prostaglandins in immune homeostasis and tissue destruction in periodontal disease","volume":"14","author":"Gemmell","year":"1997","journal-title":"Periodontol 2000"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20171212\/479975\/bsr-2017-1212.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20171212\/479975\/bsr-2017-1212.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T19:42:08Z","timestamp":1637091728000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/38\/4\/BSR20171212\/57914\/Association-of-tumor-necrosis-factor-TNF-gene"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,7,31]]},"references-count":41,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2018,8,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20171212","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,31]]},"article-number":"BSR20171212"}}