{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:10:03Z","timestamp":1768288203859,"version":"3.49.0"},"reference-count":34,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":80,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional secreted protein that can be induced by fasting, hypoxia and glucocorticoids. ANGPTL4 has been associated with a variety of diseases; however, the role of ANGPTL4 in cardiac hypertrophy remains poorly understood. In our study, we aimed to explore the effect of ANGPTL4 on phenylephrine-induced cardiomyocyte hypertrophy. Our results showed that knockdown of ANGPTL4 expression significantly exacerbated cardiomyocyte hypertrophy, as demonstrated by increased hypertrophic marker expression, including ANP and cell surface area. Moreover, significantly reduced fatty acid oxidation, as featured by decreased CPT-1 levels, was observed in hypertrophic cardiomyocytes following ANGPTL4 down-regulation. Furthermore, knockdown of ANGPLT4 led to down-regulated expression of peroxisome proliferator-activated receptor \u03b1 (PPAR\u03b1), which is the key regulator of cardiac fatty acid oxidation. In addition, ANGPTL4 silencing promoted the activation of JNK1\/2, and JNK1\/2 signaling blockade could restore the level of PPAR\u03b1 and significantly ameliorate the ANGPTL4 knockdown-induced cardiomyocyte hypertrophy. Therefore, our study demonstrated that ANGPTL4 regulates PPAR\u03b1 through JNK1\/2 signaling and is required for the inhibition of cardiomyocyte hypertrophy.<\/jats:p>","DOI":"10.1042\/bsr20171358","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T01:11:06Z","timestamp":1516151466000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["The role of angiopoietin-like protein 4 in phenylephrine-induced cardiomyocyte hypertrophy"],"prefix":"10.1042","volume":"39","author":[{"given":"Yu","family":"Sun","sequence":"first","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chen","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ruicong","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huiling","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longyun","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yugang","family":"Dong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong, China, 510080"},{"name":"Key Laboratory on Assisted Circulation, Ministry of Health, Guangzhou, Guangdong, China, 510080"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2019,7,29]]},"reference":[{"key":"2021111619384193400_B1","doi-asserted-by":"publisher","first-page":"139","DOI":"10.1177\/1470320308096048","article-title":"Blockade of calcineurin reverses cardiac hypertrophy and induces the down-regulation of JNK mRNA expression in renovascular hypertensive rats","volume":"9","author":"Sheng","year":"2008","journal-title":"J Renin Angiotensin Aldosterone Syst."},{"key":"2021111619384193400_B2","doi-asserted-by":"publisher","first-page":"1637","DOI":"10.1016\/j.jacc.2009.07.024","article-title":"The adrenergic-fatty acid load in heart failure","volume":"54","author":"Opie","year":"2009","journal-title":"J. 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