{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:36:30Z","timestamp":1753871790718,"version":"3.41.2"},"reference-count":67,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":393,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,29]]},"abstract":"<jats:p>Human cytomegalovirus (HCMV) infection, chronic inflammation and oxidative stress, the renin\u2013angiotensin system (RAS), endothelial function, and DNA methylation play roles in the pathogenesis of essential hypertension (EH); however, the mechanism by which HCMV predisposes patients to hypertension remain unclear. Our group previously demonstrated an association between EH and HCMV infection in Kazakh Chinese. Here, we investigated the relationship between HCMV infection and other clinicopathological features in 720 Kazakh individuals with or without hypertension (n=360 each; age: 18\u201380). Multiple linear and logistic regression analyses were used to determine the associations between HCMV infection, clinical characteristics, and EH. Notably, patients with EH, particularly those with HCMV infection, exhibited a marked increase in tumor necrosis factor-\u03b1 (TNF-\u03b1) and 8-hydroxy-2-deoxyguanosine (8-OHDG) levels, but a decrease in endothelial nitric oxide synthase (eNOS) and renin levels. Similarly, elevated TNF-\u03b1 and 8-OHDG levels were independent predictors of increased HCMV antibody titers, whereas eNOS and renin were negatively correlated with the latter. Moreover, serum angiotensin-converting enzyme (sACE, ACE) methylation was increased, whereas 11-\u03b2 hydroxysteroid dehydrogenase 2 (HSD11\u03b22; HSD3B2) methylation was decreased in patients with EH who were also infected with HCMV. A positive correlation between HSD3B2 methylation and HCMV IgG titer and blood pressure was additionally observed, whereas angiotensin-converting enzyme (ACE) methylation was inversely correlated with blood pressure. Collectively, these data indicate that HCMV may contribute to EH development in the Kazakh Chinese by increasing TNF-\u03b1 and 8-OHDG levels, suppressing eNOS and renin, and manipulating HSD3B2 and ACE methylation.<\/jats:p>","DOI":"10.1042\/bsr20171522","type":"journal-article","created":{"date-parts":[[2018,5,11]],"date-time":"2018-05-11T17:20:28Z","timestamp":1526059228000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Unexpected role of the human cytomegalovirus contribute to essential hypertension in the Kazakh Chinese population of Xinjiang"],"prefix":"10.1042","volume":"38","author":[{"given":"Qian","family":"Feng","sequence":"first","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Hui","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Na","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhen","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"La-Mei","family":"Wang","sequence":"additional","affiliation":[{"name":"Centre of Medical Functional Experiments, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Yuan","family":"Qu","sequence":"additional","affiliation":[{"name":"Department of Respiration Medicine, The First Affiliated Hospital of Medical College of Shihezi University, Shihezi, Xijiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Feng-Mei","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Chengdu Medical College, Sichuan, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology\/Key Laboratory of Education Ministry of Xinjiang Endemic and Ethnic Diseases, Medical College of Shihezi University, Shihezi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,6,27]]},"reference":[{"key":"2021111618583988200_B1","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1016\/j.cjca.2012.10.009","article-title":"Exploring gene-environment relationships in cardiovascular disease","volume":"29","author":"Joseph","year":"2013","journal-title":"Can. 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