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The present study aimed to investigate the effect of flurbiprofen axetil on cerebral I\/R injury and the role of inflammation in this process. Rats were subjected to sham operation or global cerebral I\/R with or without flurbiprofen axetil (5 or 10 mg\/kg). Global cerebral ischemia was achieved by occlusion of bilateral common carotid arteries combined with hypotension for 20 min followed by reperfusion for 72 h. Then the neurological deficit score, hippocampal cell apoptosis, levels of aquaporin (AQP) 4, AQP9, intercellular cell adhesion molecule-1 (ICAM-1), nuclear factor-\u03baB (NF-\u03baB), tumor necrosis factor (TNF-\u03b1), interleukin-1 \u03b2 (IL-1\u03b2), thromboxane B2 (TXB2), and 6-keto-PGI1\u03b1 were assessed. After reperfusion, neurological deficit score was significantly increased accompanied by severe neuronal damage (exacerbated morphological deficit, increased terminal deoxynucleotidyl transferase-mediated dUTP-biotin nick end labeling assay (TUNEL)-positive cells and cleaved caspase-3 protein expression in hippocampal CA1 region). Cerebral I\/R injury also enhanced expressions of TNF-\u03b1, IL-1\u03b2, NF-\u03baB, AQP4 and AQP9 as well as TXB2 and TXB2\/6-keto-PGI1\u03b1. All these changes were reversed by pretreatment with flurbiprofen axetil. Flurbiprofen axetil protects the brain from cerebral I\/R injury through reducing inflammation and brain edema.<\/jats:p>","DOI":"10.1042\/bsr20171562","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T18:15:37Z","timestamp":1521051337000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":36,"title":["Flurbiprofen axetil attenuates cerebral ischemia\/reperfusion injury by reducing inflammation in a rat model of transient global cerebral ischemia\/reperfusion"],"prefix":"10.1042","volume":"38","author":[{"given":"Huisheng","family":"Wu","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chaoliang","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, China"},{"name":"Department of Anesthesiology, The First Affiliated Hospital of University of Science and Technology of China, Hefei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lydia\u00a0Wai","family":"Tai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The University of Hong Kong, Hong Kong, SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weifeng","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peipei","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junmou","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Cardiac Surgery, Renmin Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhao","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianjuan","family":"Ke","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanlin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Zhongnan Hospital of Wuhan University, Wuhan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,7,6]]},"reference":[{"key":"2021111619000496800_B1","doi-asserted-by":"publisher","first-page":"101","DOI":"10.1016\/j.jns.2014.11.015","article-title":"Impact of hyperthermia before and during ischemia-reperfusion on neuronal damage and gliosis in the gerbil hippocampus induced by transient cerebral ischemia","volume":"348","author":"Kim","year":"2015","journal-title":"J. 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