{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T11:56:23Z","timestamp":1789041383853,"version":"build-2803163510"},"reference-count":40,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":532,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,2,28]]},"abstract":"<jats:p>Neuroblastoma, which accounts for approximately 10% of all pediatric cancer-related deaths, has become a therapeutic challenge and global burden attributed to poor outcomes and mortality rates of its high-risk form. Previous genome-wide association studies (GWASs) identified the LINC00673 rs11655237 C&amp;gt;T polymorphism to be associated with the susceptibility of several malignant tumors. However, the association between this polymorphism and neuroblastoma susceptibility is not clear. We genotyped LINC00673 rs11655237 C&amp;gt;T in 393 neuroblastoma patients in comparison with 812 age-, gender-, and ethnicity-matched healthy controls. We found a significant association between the LINC00673 rs11655237 C&amp;gt;T polymorphism and neuroblastoma risk (TT compared with CC: adjusted odds ratio (OR) =1.80, 95% confidence interval (CI) =1.06\u20133.06, P=0.029; TT\/CT compared with CC: adjusted OR =1.31, 95% CI =1.02\u20131.67, P=0.033; and T compared with C: adjusted OR =1.29, 95% CI =1.06\u20131.58, P=0.013). Furthermore, stratified analysis indicated that the rs11655237 T allele carriers were associated with increased neuroblastoma risk for patients with tumor originating from the adrenal gland (adjusted OR =1.51, 95% CI =1.06\u20132.14, P=0.021) and International Neuroblastoma Staging System (INSS) stage IV disease (adjusted OR =1.60, 95% CI =1.12\u20132.30, P=0.011). In conclusion, we verified that the LINC00673 rs11655237 C&amp;gt;T polymorphism might be associated with neuroblastoma susceptibility. Prospective studies with a large sample size and different ethnicities are needed to validate our findings.<\/jats:p>","DOI":"10.1042\/bsr20171667","type":"journal-article","created":{"date-parts":[[2018,1,17]],"date-time":"2018-01-17T01:11:06Z","timestamp":1516151466000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["<i>LINC00673<\/i> rs11655237 C&amp;gt;T confers neuroblastoma susceptibility in Chinese population"],"prefix":"10.1042","volume":"38","author":[{"given":"Zhuorong","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yitian","family":"Chang","sequence":"additional","affiliation":[{"name":"College of Clinical Medicine, Jilin University, Changchun 130021, Jilin, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Jia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruizhong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinhong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Molecular Epidemiology Laboratory and Department of Laboratory Medicine, Harbin Medical University Cancer Hospital, Harbin 150040, Heilongjiang, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianyou","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0103-1672","authenticated-orcid":false,"given":"Huimin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Zou","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1954-2892","authenticated-orcid":false,"given":"Jing","family":"He","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Institute of Pediatrics, Guangzhou Women and Children\u2019s Medical Center, Guangzhou Medical University, Guangzhou 510623, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,2,8]]},"reference":[{"key":"2021111618511135100_B1","doi-asserted-by":"publisher","first-page":"j1863","DOI":"10.1136\/bmj.j1863","article-title":"Neuroblastoma","volume":"357","author":"Shohet","year":"2017","journal-title":"BMJ"},{"key":"2021111618511135100_B2","doi-asserted-by":"publisher","first-page":"704","DOI":"10.1038\/nrclinonc.2014.168","article-title":"Mechanisms of neuroblastoma regression","volume":"11","author":"Brodeur","year":"2014","journal-title":"Nat. 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