{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T06:27:55Z","timestamp":1778826475870,"version":"3.51.4"},"reference-count":21,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":491,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,4,27]]},"abstract":"<jats:p>Graves\u2019 disease (GD) is a common autoimmune disorder with a genetic predisposition. Owing to the biological effect of tumor necrosis factor-\u03b1 (TNF-\u03b1) on the thyroid gland and its gene location, TNF-\u03b1 should be able to influence an individual\u2019s susceptibility to GD. In the present study, we conduct a meta-analysis of rs1800629 and rs361525 in TNF-\u03b1 gene from all eligible case\u2013control studies to assess the associations amongst reported TNF-\u03b1 gene with GD. A total of ten case\u2013control studies involving 2790 GD patients and 3472 healthy controls were included. The results showed that a significant association was characterized between the rs1800629 polymorphism and GD in the homozygous model (AA compared with GG: odds ratio (OR) = 1.97, 95% confidence interval (CI) = 1.27\u20133.06, P=0.002) and recessive model (AA compared with GA + GG: OR = 1.62, 95% CI = 1.04\u20132.50, P=0.03). GD susceptibility was significantly detected in European population in all genetic models after ethnicity stratification. In sharp contrast, no significant association could be detected in Asian population. Next, we conducted a meta-analysis for another promoter SNP rs361525. However, SNP rs361525 did not show a significant association with GD in any genetic model before and after ethnicity stratification. Together, our data support that only the promoter single-nucleotide polymorphism (SNP) rs1800629 within the TNF-\u03b1 gene is associated with increased risk for developing GD, especially in European population. Future large-scale studies are required to validate the associations between TNF-\u03b1 gene and GD.<\/jats:p>","DOI":"10.1042\/bsr20180143","type":"journal-article","created":{"date-parts":[[2018,2,14]],"date-time":"2018-02-14T01:10:38Z","timestamp":1518570638000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Association of <i>TNF-\u03b1<\/i> promoter polymorphism and Graves\u2019 disease: an updated systematic review and meta-analysis"],"prefix":"10.1042","volume":"38","author":[{"given":"Yaqin","family":"Tu","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guorun","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tianshu","family":"Zeng","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiong","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wen","family":"Kong","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave., Wuhan 430022, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,3,21]]},"reference":[{"key":"2021111618545829500_B1","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1093\/bmb\/ldr030","article-title":"The epidemiology of thyroid disease","volume":"99","author":"Vanderpump","year":"2011","journal-title":"Br. Med. Bull."},{"key":"2021111618545829500_B2","doi-asserted-by":"publisher","first-page":"721","DOI":"10.1089\/jir.2011.0049","article-title":"Role of cytokines in the pathogenesis and suppression of thyroid autoimmunity","volume":"31","author":"Ganesh","year":"2011","journal-title":"J. Interferon Cytokine Res."},{"key":"2021111618545829500_B3","first-page":"3394","article-title":"Linkage disequilibrium between the human leukocyte antigen class II region of the major histocompatibility complex and Graves\u2019 disease: replication using a population case control and family-based study","volume":"83","author":"Heward","year":"1998","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021111618545829500_B4","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1210\/jcem-61-4-735","article-title":"The genetics of Graves\u2019 disease: HLA and disease susceptibility","volume":"61","author":"Stenszky","year":"1985","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"2021111618545829500_B5","doi-asserted-by":"publisher","first-page":"329","DOI":"10.1093\/rheumatology\/41.3.329","article-title":"The role of TNF-alpha in the pathogenesis of inflammation and joint destruction in rheumatoid arthritis (RA): a study using a human RA\/SCID mouse chimera","volume":"41","author":"Matsuno","year":"2002","journal-title":"Rheumatology (Oxford)"},{"key":"2021111618545829500_B6","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1038\/sj.gene.6364066","article-title":"A systematic approach to the assessment of known TNF-alpha polymorphisms in Graves\u2019 disease","volume":"5","author":"Simmonds","year":"2004","journal-title":"Genes Immun."},{"key":"2021111618545829500_B7","doi-asserted-by":"publisher","first-page":"216","DOI":"10.1002\/1097-0029(20000801)50:3%3c216::AID-JEMT5%3e3.0.CO;2-Q","article-title":"TNF-alpha gene polymorphism: clinical and biological implications","volume":"50","author":"Hajeer","year":"2000","journal-title":"Microsc. Res. Tech."},{"key":"2021111618545829500_B8","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.humimm.2004.02.033","article-title":"Association of tumor necrosis factor and human leukocyte antigen DRB1 alleles with Graves\u2019 ophthalmopathy","volume":"65","author":"Bednarczuk","year":"2004","journal-title":"Hum. Immunol."},{"key":"2021111618545829500_B9","doi-asserted-by":"publisher","first-page":"e105492","DOI":"10.1371\/journal.pone.0105492","article-title":"Polymorphisms in the TNFA and IL6 genes represent risk factors for autoimmune thyroid disease","volume":"9","author":"Duraes","year":"2014","journal-title":"PLoS ONE"},{"key":"2021111618545829500_B10","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1016\/j.clinbiochem.2008.04.014","article-title":"Association of tumour necrosis factor alpha (TNF-alpha) polymorphisms with Graves\u2019 disease: a meta-analysis","volume":"41","author":"Li","year":"2008","journal-title":"Clin. Biochem."},{"key":"2021111618545829500_B11","doi-asserted-by":"publisher","first-page":"163","DOI":"10.2174\/18715303113139990001","article-title":"Association of cytokine gene polymorphisms (IL6, IL10, TNF-alpha, TGF-beta and IFN-gamma) and Graves\u2019 disease in Turkish population","volume":"13","author":"Kutluturk","year":"2013","journal-title":"Endocr. Metab. Immune Disord. Drug Targets"},{"key":"2021111618545829500_B12","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1007\/s12020-010-9311-y","article-title":"Graves\u2019 disease and gene polymorphism of TNF-alpha, IL-2, IL-6, IL-12, and IFN-gamma","volume":"37","author":"Anvari","year":"2010","journal-title":"Endocrine"},{"key":"2021111618545829500_B13","doi-asserted-by":"publisher","first-page":"223","DOI":"10.1016\/j.clinbiochem.2009.08.012","article-title":"Tumor necrosis factor alpha (TNF-alpha) polymorphisms in Chinese patients with Graves\u2019 disease","volume":"43","author":"Gu","year":"2010","journal-title":"Clin. Biochem."},{"key":"2021111618545829500_B14","doi-asserted-by":"publisher","first-page":"213","DOI":"10.1016\/j.clinbiochem.2006.11.009","article-title":"Cytokine promoter polymorphisms in Taiwanese patients with Graves\u2019 disease","volume":"40","author":"Shiau","year":"2007","journal-title":"Clin. Biochem."},{"key":"2021111618545829500_B15","doi-asserted-by":"publisher","first-page":"343","DOI":"10.1111\/j.1744-313X.2005.00536.x","article-title":"Lack of association between pro-inflammatory cytokine (IL-6, IL-8 and TNF-alpha) gene polymorphisms and Graves\u2019 disease","volume":"32","author":"Chen","year":"2005","journal-title":"Int. J. Immunogenet."},{"key":"2021111618545829500_B16","doi-asserted-by":"publisher","first-page":"759","DOI":"10.1046\/j.1365-2265.2000.01011.x","article-title":"A polymorphism of the 5\u2032 flanking region of tumour necrosis factor alpha gene is associated with thyroid-associated ophthalmopathy in Japanese","volume":"52","author":"Kamizono","year":"2000","journal-title":"Clin. Endocrinol. (Oxf.)"},{"key":"2021111618545829500_B17","doi-asserted-by":"publisher","first-page":"e59349","DOI":"10.1371\/journal.pone.0059349","article-title":"Association between age at diagnosis of Graves\u2019 disease and variants in genes involved in immune response","volume":"8","author":"Jurecka-Lubieniecka","year":"2013","journal-title":"PLoS ONE"},{"key":"2021111618545829500_B18","doi-asserted-by":"publisher","first-page":"123","DOI":"10.1007\/s12020-015-0764-x","article-title":"Normal human thyroid cells, BCPAP, and TPC-1 thyroid tumor cell lines display different profile in both basal and TNF-alpha-induced CXCL8 secretion","volume":"54","author":"Coperchini","year":"2016","journal-title":"Endocrine"},{"key":"2021111618545829500_B19","doi-asserted-by":"publisher","first-page":"1108","DOI":"10.1093\/nar\/22.6.1108","article-title":"Identification and characterization of a novel repressor site in the human tumor necrosis factor alpha gene","volume":"22","author":"Fong","year":"1994","journal-title":"Nucleic Acids Res."},{"key":"2021111618545829500_B20","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1046\/j.1365-2249.1998.00662.x","article-title":"Tumour necrosis factor (TNF) gene polymorphism influences TNF-alpha production in lipopolysaccharide (LPS)-stimulated whole blood cell culture in healthy humans","volume":"113","author":"Louis","year":"1998","journal-title":"Clin. Exp. Immunol."},{"key":"2021111618545829500_B21","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1006\/cyto.2001.0902","article-title":"Functional analysis of linker-scan mutants spanning the -376, -308, -244, and -238 polymorphic sites of the TNF-alpha promoter","volume":"14","author":"Bayley","year":"2001","journal-title":"Cytokine"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20180143\/483164\/bsr-2018-0143.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20180143\/483164\/bsr-2018-0143.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T19:34:28Z","timestamp":1637091268000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/38\/2\/BSR20180143\/57496\/Association-of-TNF-promoter-polymorphism-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,3,21]]},"references-count":21,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2018,4,27]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20180143","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,21]]},"article-number":"BSR20180143"}}