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In the present study, C57BL\/6 mice received intraperitoneal injections of either saline, 4.25% high glucose (HG) PD fluid (PDF) or PDF plus Tamoxifen each day for 30 days. Tamoxifen attenuated thickening of the peritoneum, and reversed PDF-induced peritoneal expression of E-cadherin, Vimentin, matrix metalloproteinase 9 (MMP9), Snail, and \u03b2-catenin. Mouse peritoneal mesothelial cells (mPMCs) were cultured in 4.25% glucose or 4.25% glucose plus Tamoxifen for 48 h. Tamoxifen inhibited epithelial-to-mesenchymal transition (EMT) as well as phosphorylation of glycogen synthase kinase-3\u03b2 (GSK-3\u03b2), nuclear \u03b2-catenin, and Snail induced by exposure to HG. TWS119 reversed the effects of Tamoxifen on \u03b2-catenin and Snail expression. In conclusion, Tamoxifen significantly attenuated EMT during peritoneal epithelial fibrosis, in part by inhibiting GSK-3\u03b2\/\u03b2-catenin activation.<\/jats:p>","DOI":"10.1042\/bsr20180240","type":"journal-article","created":{"date-parts":[[2018,7,30]],"date-time":"2018-07-30T16:55:27Z","timestamp":1532969727000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Tamoxifen attenuates dialysate-induced peritoneal fibrosis by inhibiting GSK-3\u03b2\/\u03b2-catenin axis activation"],"prefix":"10.1042","volume":"38","author":[{"given":"Pengpeng","family":"Yan","sequence":"first","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Huanna","family":"Tang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoying","family":"Chen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuiyu","family":"Ji","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhejiang Provincial People\u2019s Hospital, People\u2019s Hospital of Hangzhou Medical College, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Jin","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Tongxiang First People\u2019s Hospital, Jiaxing 314500, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaming","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhejiang Provincial People\u2019s Hospital, People\u2019s Hospital of Hangzhou Medical College, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jia","family":"Shen","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hao","family":"Deng","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhejiang Provincial People\u2019s Hospital, People\u2019s Hospital of Hangzhou Medical College, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6704-6247","authenticated-orcid":false,"given":"Quanquan","family":"Shen","sequence":"additional","affiliation":[{"name":"Department of Nephrology, Zhejiang Provincial People\u2019s Hospital, People\u2019s Hospital of Hangzhou Medical College, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongfeng","family":"Huang","sequence":"additional","affiliation":[{"name":"Kidney Disease Center, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310003, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,11,21]]},"reference":[{"key":"2021111619223873000_B1","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1016\/S0272-6386(97)90276-6","article-title":"Hemodialysis versus peritoneal dialysis: a comparison of adjusted mortality rates","volume":"30","author":"Fenton","year":"1997","journal-title":"Am. 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