{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T22:39:46Z","timestamp":1782945586142,"version":"3.54.5"},"reference-count":25,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":408,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,6,29]]},"abstract":"<jats:p>The long-term chronic inflammation of cervical intraepithelial neoplasia (CIN) induces the initiation and progression of cervical cancer. Long non-coding RNAs (LncRNAs) are being identified to be involved into inflammation and carcinogenesis and could function as cancer biomarkers in clinical. However, the significance of inflammation-related LncRNA (e.g. LncRNA-IL7R) in cervical cancer is limited. We, here, investigated the clinical role of inflammation-related LncRNA-IL7R (Lnc-IL7R) in healthy cervical tissue (n=15), CIN 1\/2\/3 (n=35), cervical cancer (n=70), and clarified its function via knockdown in vitro and in vivo. The results showed that the expression of Lnc-IL7R was increased from normal tissues to neoplastic lesions and cervical cancer. Up-regulated Lnc-IL7R positively correlated to tumor size, International Federation of Gynaecology and Obstetrics (FIGO) stage, and lymph node metastasis (LNM). Patients with high expression of Lnc-IL7R had poor prognosis with short overall survival (OS) time, and Cox regression analysis revealed that Lnc-IL7R could be independent prognostic factor for cervical cancer. Moreover, knockdown of Lnc-IL7R by two different siRNAs in cervical cancer cell lines Hela and SiHa induced impaired cell vitality and caspase-3-dependent apoptosis in vitro. Furthermore, inhibition of Lnc-IL7R in vivo significantly restricted the tumor growth with decreased expressions of proliferation index Ki-67 and Lnc-IL7R. These data indicated that Lnc-IL7R predicts a poor clinical outcome of cervical cancer patients, and knockdown of Lnc-IL7R is amenable to the treatment of cervical cancer.<\/jats:p>","DOI":"10.1042\/bsr20180483","type":"journal-article","created":{"date-parts":[[2018,5,2]],"date-time":"2018-05-02T16:20:33Z","timestamp":1525278033000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Up-regulation of inflammation-related LncRNA-IL7R predicts poor clinical outcome in patients with cervical cancer"],"prefix":"10.1042","volume":"38","author":[{"given":"Yangyang","family":"Fan","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Shaanxi Provincial People's Hospital. Xi'an City, Shaanxi Province. 710068, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Nan","sequence":"additional","affiliation":[{"name":"Department of Gynecology. Northwest Women and Children Hospital. Xi'an, Shaanxi Province, 716001, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juanjuan","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, affiliated Hospital of Yan'an University. Yan'an, Shaanxi Province, 716000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Gynecology, No. 215 Hospital of Shaanxi Nuclear Industry. Xianyang, Shaanxi Province, 712000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Weidong","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The first Hospital of Yulin City. 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