{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T21:32:48Z","timestamp":1790199168502,"version":"4.1.0"},"reference-count":137,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":314,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>Angiopoietin-like protein 4 (ANGPTL4) is a multifunctional cytokine regulating vascular permeability, angiogenesis, and inflammation. Dysregulations in these responses contribute to the pathogenesis of ischemic retinopathies such as diabetic retinopathy (DR), age-related macular degeneration (AMD), retinal vein occlusion, and sickle cell retinopathy (SCR). However, the role of ANGPTL4 in these diseases remains controversial. Here, we summarize the functional mechanisms of ANGPTL4 in several diseases. We highlight original studies that provide detailed data about the mechanisms of action for ANGPTL4, its applications as a diagnostic or prognostic biomarker, and its use as a potential therapeutic target. Taken together, the discussions in this review will help us gain a better understanding of the molecular mechanisms by which ANGPTL4 functions in eye disease and will provide directions for future research.<\/jats:p>","DOI":"10.1042\/bsr20180557","type":"journal-article","created":{"date-parts":[[2018,7,26]],"date-time":"2018-07-26T14:35:17Z","timestamp":1532615717000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["A review of the multifunctionality of angiopoietin-like 4 in eye disease"],"prefix":"10.1042","volume":"38","author":[{"given":"Xinyue","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guanfang","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology, The Second Hospital of Jilin University, Changchun 130041, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"2021111619115727400_B1","doi-asserted-by":"publisher","first-page":"28488","DOI":"10.1074\/jbc.M004029200","article-title":"Characterization of the fasting-induced adipose factor FIAF, a novel peroxisome proliferator-activated receptor target gene","volume":"275","author":"Kersten","year":"2000","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B2","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1042\/bj3460603","article-title":"Hepatic expression, synthesis and secretion of a novel fibrinogen\/angiopoietin-related protein that prevents endothelial-cell apoptosis","volume":"346","author":"Kim","year":"2000","journal-title":"Biochem. J."},{"key":"2021111619115727400_B3","doi-asserted-by":"publisher","first-page":"5343","DOI":"10.1128\/MCB.20.14.5343-5349.2000","article-title":"Peroxisome proliferator-activated receptor gamma target gene encoding a novel angiopoietin-related protein associated with adipose differentiation","volume":"20","author":"Yoon","year":"2000","journal-title":"Mol. Cell. Biol."},{"key":"2021111619115727400_B4","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1586\/epr.12.12","article-title":"Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships","volume":"9","author":"Grootaert","year":"2012","journal-title":"Expert Rev. Proteomics"},{"key":"2021111619115727400_B5","doi-asserted-by":"publisher","first-page":"16122","DOI":"10.1074\/jbc.M117.803973","article-title":"The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure","volume":"292","author":"McQueen","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B6","doi-asserted-by":"publisher","first-page":"249","DOI":"10.1097\/MOL.0000000000000290","article-title":"Regulation of lipid metabolism by angiopoietin-like proteins","volume":"27","author":"Dijk","year":"2016","journal-title":"Curr. Opin. Lipidol."},{"key":"2021111619115727400_B7","first-page":"94","article-title":"Cloning of a novel gene, ANGPTL4 and the functional study in angiogenesis","volume":"82","author":"Zhu","year":"2002","journal-title":"Natl. Med. J. China"},{"key":"2021111619115727400_B8","doi-asserted-by":"publisher","first-page":"181","DOI":"10.1586\/epr.12.12","article-title":"Angiopoietin-like protein 4: health effects, modulating agents and structure-function relationships","volume":"9","author":"Grootaert","year":"2012","journal-title":"Expert Rev. Proteomics"},{"key":"2021111619115727400_B9","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-25237-7","article-title":"Structures of Angptl3 and Angptl4, modulators of triglyceride levels and coronary artery disease","volume":"8","author":"Biterova","year":"2018","journal-title":"Sci. Rep."},{"key":"2021111619115727400_B10","doi-asserted-by":"publisher","first-page":"473","DOI":"10.1016\/j.molmed.2005.08.002","article-title":"Angiopoietin-like proteins: potential new targets for metabolic syndrome therapy","volume":"11","author":"Oike","year":"2005","journal-title":"Trends Mol. Med."},{"key":"2021111619115727400_B11","doi-asserted-by":"publisher","first-page":"2791","DOI":"10.2353\/ajpath.2010.100129","article-title":"Angiopoietin-like 4 interacts with integrins \u03b21 and \u03b25 to modulate keratinocyte migration","volume":"177","author":"Yan","year":"2010","journal-title":"Am. J. Pathol."},{"key":"2021111619115727400_B12","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1002\/path.4805","article-title":"ANGPTL4-alphavbeta3 interaction counteracts hypoxia-induced vascular permeability by modulating Src signalling downstream of vascular endothelial growth factor receptor 2","volume":"240","author":"Gomez Perdiguero","year":"2016","journal-title":"J. Pathol."},{"key":"2021111619115727400_B13","doi-asserted-by":"publisher","first-page":"11865","DOI":"10.1074\/jbc.M114.623769","article-title":"Angiopoietin-like 4 modifies the interactions between lipoprotein lipase and its endothelial cell transporter GPIHBP1","volume":"290","author":"Chi","year":"2015","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B14","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.devcel.2017.09.011","article-title":"Angiopoietin-like 4 is a Wnt signaling antagonist that promotes LRP6 turnover","volume":"43","author":"Kirsch","year":"2017","journal-title":"Dev. Cell"},{"key":"2021111619115727400_B15","doi-asserted-by":"publisher","first-page":"3990","DOI":"10.1182\/blood-2011-01-328716","article-title":"ANGPTL4 modulates vascular junction integrity by integrin signaling and disruption of intercellular VE-cadherin and claudin-5 clusters","volume":"118","author":"Huang","year":"2011","journal-title":"Blood"},{"key":"2021111619115727400_B16","doi-asserted-by":"publisher","first-page":"6303","DOI":"10.1038\/s41598-017-05869-x","article-title":"Angiopoietin-like 4 induces a beta-catenin-mediated upregulation of ID3 in fibroblasts to reduce scar collagen expression","volume":"7","author":"Teo","year":"2017","journal-title":"Sci. Rep."},{"key":"2021111619115727400_B17","doi-asserted-by":"publisher","first-page":"13213","DOI":"10.1074\/jbc.M900553200","article-title":"Genetic variation in ANGPTL4 provides insights into protein processing and function","volume":"284","author":"Yin","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B18","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1161\/ATVBAHA.107.157776","article-title":"Suppression of the Raf\/MEK\/ERK signaling cascade and inhibition of angiogenesis by the carboxyl terminus of angiopoietin-like protein 4","volume":"28","author":"Yang","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021111619115727400_B19","doi-asserted-by":"publisher","first-page":"6086","DOI":"10.1073\/pnas.0408452102","article-title":"Angiopoietin-like protein 4 decreases blood glucose and improves glucose tolerance but induces hyperlipidemia and hepatic steatosis in mice","volume":"102","author":"Xu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B20","doi-asserted-by":"publisher","first-page":"e289","DOI":"10.1111\/aos.12097","article-title":"Angiopoietin-like protein 4 (ANGPTL4) is induced by high glucose in retinal pigment epithelial cells and exhibits potent angiogenic activity on retinal endothelial cells","volume":"91","author":"Yokouchi","year":"2013","journal-title":"Acta Ophthalmol."},{"key":"2021111619115727400_B21","doi-asserted-by":"publisher","first-page":"677","DOI":"10.1158\/1541-7786.MCR-11-0519","article-title":"Emerging roles of angiopoietin-like 4 in human cancer","volume":"10","author":"Tan","year":"2012","journal-title":"Mol. Cancer Res."},{"key":"2021111619115727400_B22","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1017\/S0007114507882961","article-title":"Regulation of angiopoietin-like protein 4\/fasting-induced adipose factor (Angptl4\/FIAF) expression in mouse white adipose tissue and 3T3-L1 adipocytes","volume":"100","author":"Dutton","year":"2008","journal-title":"Br. J. Nutr."},{"key":"2021111619115727400_B23","doi-asserted-by":"publisher","first-page":"765","DOI":"10.1006\/jmcc.2002.2021","article-title":"Hypoxia up-regulates expression of peroxisome proliferator-activated receptor angiopoietin-related gene (PGAR) in cardiomyocytes: role of hypoxia inducible factor 1","volume":"34","author":"Belanger","year":"2002","journal-title":"J. Mol. Cell Cardiol."},{"key":"2021111619115727400_B24","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1677\/JOE-07-0158","article-title":"Fasting-induced adipose factor identified as a key adipokine that is up-regulated in white adipose tissue during pregnancy and lactation in the rat","volume":"194","author":"Josephs","year":"2007","journal-title":"J. Endocrinol."},{"key":"2021111619115727400_B25","doi-asserted-by":"publisher","first-page":"969","DOI":"10.1161\/ATVBAHA.108.182147","article-title":"Caloric restriction and exercise increase plasma ANGPTL4 levels in humans via elevated free fatty acids","volume":"29","author":"Kersten","year":"2009","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021111619115727400_B26","doi-asserted-by":"publisher","first-page":"255","DOI":"10.3945\/ajcn.112.043687","article-title":"Dietary modulation of plasma angiopoietin-like protein 4 concentrations in healthy volunteers and in patients with type 2 diabetes","volume":"97","author":"Jonker","year":"2013","journal-title":"Am. J. Clin. Nutr."},{"key":"2021111619115727400_B27","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1016\/j.jacl.2017.10.016","article-title":"Short-term cooling increases serum angiopoietin-like 4 levels in healthy lean men","volume":"12","author":"Nahon","year":"2018","journal-title":"J. Clin. Lipidol."},{"key":"2021111619115727400_B28","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1016\/j.ejcb.2015.10.004","article-title":"Hypoxia induced HIF-1\/HIF-2 activity alters trophoblast transcriptional regulation and promotes invasion","volume":"94","author":"Highet","year":"2015","journal-title":"Eur. J. Cell Biol."},{"key":"2021111619115727400_B29","doi-asserted-by":"publisher","first-page":"3605","DOI":"10.4049\/jimmunol.1500740","article-title":"\u03b11-antitrypsin combines with plasma fatty acids and induces angiopoietin-like protein 4 expression","volume":"195","author":"Frenzel","year":"2015","journal-title":"J. Immunol."},{"key":"2021111619115727400_B30","doi-asserted-by":"publisher","first-page":"44857","DOI":"10.1074\/jbc.M304489200","article-title":"Identification of the downstream targets of SIM1 and ARNT2, a pair of transcription factors essential for neuroendocrine cell differentiation","volume":"278","author":"Liu","year":"2003","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B31","doi-asserted-by":"publisher","first-page":"11975","DOI":"10.1158\/0008-5472.CAN-06-1529","article-title":"Peroxisome proliferator-activated receptor gamma is a Zac target gene mediating Zac antiproliferation","volume":"66","author":"Barz","year":"2006","journal-title":"Cancer Res."},{"key":"2021111619115727400_B32","doi-asserted-by":"publisher","first-page":"34411","DOI":"10.1074\/jbc.M403058200","article-title":"The direct peroxisome proliferator-activated receptor target fasting-induced adipose factor (FIAF\/PGAR\/ANGPTL4) is present in blood plasma as a truncated protein that is increased by fenofibrate treatment","volume":"279","author":"Mandard","year":"2004","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B33","doi-asserted-by":"publisher","first-page":"15603","DOI":"10.1073\/pnas.0407008101","article-title":"Chromatin immunoprecipitation (ChIP) scanning identifies primary glucocorticoid receptor target genes","volume":"101","author":"Wang","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B34","doi-asserted-by":"publisher","first-page":"241","DOI":"10.1007\/s40618-017-0730-y","article-title":"Peroxisome proliferator-activated receptor gamma expression in peripheral blood mononuclear cells and angiopoietin-like protein 4 levels in obese children and adolescents","volume":"41","author":"Sadeghabadi","year":"2017","journal-title":"J. Endocrinol. Invest."},{"key":"2021111619115727400_B35","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8306","article-title":"Buyang Huanwu Tang improves denervation-dependent muscle atrophy by increasing ANGPTL4, and increases NF-\u03baB and MURF1 levels","author":"Zhou","year":"2017","journal-title":"Mol. Med. Rep."},{"key":"2021111619115727400_B36","doi-asserted-by":"publisher","first-page":"e73146","DOI":"10.1371\/journal.pone.0073146","article-title":"c-Myc is essential to prevent endothelial pro-inflammatory senescent phenotype","volume":"8","author":"Florea","year":"2013","journal-title":"PLoS ONE"},{"key":"2021111619115727400_B37","doi-asserted-by":"publisher","first-page":"R63","DOI":"10.1186\/gb-2014-15-4-r63","article-title":"Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta\/delta is the result of the conformational proximity of two response elements","volume":"15","author":"Inoue","year":"2014","journal-title":"Genome Biol."},{"key":"2021111619115727400_B38","doi-asserted-by":"publisher","first-page":"29469","DOI":"10.1074\/jbc.M110.142018","article-title":"Transcriptional profiling identifies functional interactions of TGF beta and PPAR beta\/delta signaling: synergistic induction of ANGPTL4 transcription","volume":"285","author":"Kaddatz","year":"2010","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B39","doi-asserted-by":"publisher","first-page":"137","DOI":"10.1016\/j.biopha.2017.09.105","article-title":"Paeoniflorin ameliorates Adriamycin-induced nephrotic syndrome through the PPAR\u03b3\/ANGPTL4 pathway in vivo and vitro","volume":"96","author":"Lu","year":"2017","journal-title":"Biomed. Pharmacother."},{"key":"2021111619115727400_B40","doi-asserted-by":"publisher","first-page":"507","DOI":"10.1016\/j.yexcr.2009.12.004","article-title":"Induction of ANGPTL4 expression in human airway smooth muscle cells by PMA through activation of PKC and MAPK pathways","volume":"316","author":"Stapleton","year":"2010","journal-title":"Exp. Cell Res."},{"key":"2021111619115727400_B41","doi-asserted-by":"publisher","first-page":"172","DOI":"10.1016\/j.archoralbio.2017.10.011","article-title":"L-mimosine and hypoxia enhance angiopoietin-like 4 production involving hypoxia-inducible factor-1alpha: Insights from monolayer and spheroid cultures of dental pulp-derived cells and tooth slice cultures","volume":"85","author":"Janjic","year":"2018","journal-title":"Arch. Oral Biol"},{"key":"2021111619115727400_B42","doi-asserted-by":"publisher","first-page":"578","DOI":"10.3892\/br.2015.468","article-title":"Advanced glycation end products upregulate angiopoietin-like protein 4 expression by activating the renin-angiotensin system in endothelial cells","volume":"3","author":"Zheng","year":"2015","journal-title":"Biomed. Rep."},{"key":"2021111619115727400_B43","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1155\/2017\/4313561","article-title":"Chiglitazar preferentially regulates gene expression via configuration-restricted binding and phosphorylation inhibition of PPAR\u03b3","volume":"2017","author":"Pan","year":"2017","journal-title":"PPAR Res."},{"key":"2021111619115727400_B44","doi-asserted-by":"publisher","first-page":"919","DOI":"10.1194\/jlr.M047860","article-title":"Repression of glucocorticoid-stimulated angiopoietin-like 4 gene transcription by insulin","volume":"55","author":"Kuo","year":"2014","journal-title":"J. Lipid Res."},{"key":"2021111619115727400_B45","doi-asserted-by":"publisher","first-page":"1737","DOI":"10.1016\/j.bbrc.2009.12.145","article-title":"The acute phase response stimulates the expression of angiopoietin like protein 4","volume":"391","author":"Lu","year":"2010","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111619115727400_B46","doi-asserted-by":"publisher","first-page":"533","DOI":"10.1016\/j.bbalip.2017.02.005","article-title":"TNF-alpha decreases lipoprotein lipase activity in 3T3-L1 adipocytes by up-regulation of angiopoietin-like protein 4","volume":"1862","author":"Makoveichuk","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111619115727400_B47","doi-asserted-by":"publisher","first-page":"4648","DOI":"10.1096\/fj.10-162230","article-title":"Hypoxia-inducible factor regulates osteoclast-mediated bone resorption: role of angiopoietin-like 4","volume":"24","author":"Knowles","year":"2010","journal-title":"FASEB J."},{"key":"2021111619115727400_B48","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.13405","article-title":"The long non-coding RNA PVT1 represses ANGPTL4 transcription through binding with EZH2 in trophoblast cell","author":"Xu","year":"2017","journal-title":"J. Cell. Mol. Med."},{"key":"2021111619115727400_B49","doi-asserted-by":"publisher","first-page":"1767","DOI":"10.1073\/pnas.0409564102","article-title":"Inhibition of cardiac lipoprotein utilization by transgenic overexpression of Angptl4 in the heart","volume":"102","author":"Yu","year":"2005","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B50","doi-asserted-by":"publisher","first-page":"15718","DOI":"10.1073\/pnas.0407076101","article-title":"The gut microbiota as an environmental factor that regulates fat storage","volume":"101","author":"B\u00e4ckhed","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B51","first-page":"P280","article-title":"Regulation of brain-derived resistin and FIAF in a novel hypothalamic neuronal cell line","volume":"11","author":"Brown","year":"2007","journal-title":"Endocrine Abstracts"},{"key":"2021111619115727400_B52","doi-asserted-by":"publisher","first-page":"E3425","DOI":"10.1073\/pnas.1217091110","article-title":"Hypoxic retinal Muller cells promote vascular permeability by HIF-1-dependent up-regulation of angiopoietin-like 4","volume":"110","author":"Xin","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B53","doi-asserted-by":"publisher","first-page":"579","DOI":"10.2337\/db07-1438","article-title":"Muscle-derived angiopoietin-like protein 4 is induced by fatty acids via peroxisome proliferator-activated receptor (PPAR)-delta and is of metabolic relevance in humans","volume":"58","author":"Staiger","year":"2009","journal-title":"Diabetes"},{"key":"2021111619115727400_B54","doi-asserted-by":"publisher","first-page":"231","DOI":"10.1177\/1479164110369848","article-title":"Tissue-specific effects of valsartan on rstn and fiaf gene expression in the ob\/ob mouse","volume":"7","author":"Imran","year":"2010","journal-title":"Diabetes Vasc. Dis. Res."},{"key":"2021111619115727400_B55","doi-asserted-by":"publisher","first-page":"2772","DOI":"10.2337\/db10-0145","article-title":"Hypothalamic Angptl4\/Fiaf is a novel regulator of food intake and body weight","volume":"59","author":"Kim","year":"2010","journal-title":"Diabetes"},{"key":"2021111619115727400_B56","doi-asserted-by":"publisher","first-page":"809","DOI":"10.1016\/j.molmet.2017.06.007","article-title":"Angiopoietin-like 4 directs uptake of dietary fat away from adipose during fasting","volume":"6","author":"Cushing","year":"2017","journal-title":"Mol. Metab."},{"key":"2021111619115727400_B57","doi-asserted-by":"publisher","first-page":"e005973","DOI":"10.1161\/JAHA.117.005973","article-title":"Angiopoietin-like protein 4 is a high-density lipoprotein (HDL) component for HDL metabolism and function in nondiabetic participants and type-2 diabetic patients","volume":"6","author":"Yang","year":"2017","journal-title":"J. Am. Heart Assoc."},{"key":"2021111619115727400_B58","doi-asserted-by":"publisher","first-page":"16122","DOI":"10.1074\/jbc.M117.803973","article-title":"The C-terminal fibrinogen-like domain of angiopoietin-like 4 stimulates adipose tissue lipolysis and promotes energy expenditure","volume":"292","author":"Mcqueen","year":"2017","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B59","doi-asserted-by":"publisher","first-page":"1056","DOI":"10.1016\/j.bbalip.2017.07.005","article-title":"ANGPTL4 promotes bile acid absorption during taurocholic acid supplementation via a mechanism dependent on the gut microbiota","volume":"1862","author":"Janssen","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111619115727400_B60","doi-asserted-by":"publisher","first-page":"e45","DOI":"10.1017\/jns.2016.38","article-title":"A randomised, controlled, crossover study of the effect of diet on angiopoietin-like protein 4 (ANGPTL4) through modification of the gut microbiome","volume":"5","author":"Blaedel","year":"2016","journal-title":"J. Nutr. Sci."},{"key":"2021111619115727400_B61","doi-asserted-by":"publisher","first-page":"25593","DOI":"10.1074\/jbc.M109.025452","article-title":"Angiopoietin-like 4 (ANGPTL4, fasting-induced adipose factor) is a direct glucocorticoid receptor target and participates in glucocorticoid-regulated triglyceride metabolism","volume":"284","author":"Koliwad","year":"2009","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B62","doi-asserted-by":"publisher","first-page":"2319","DOI":"10.1161\/ATVBAHA.108.176917","article-title":"ANGPTL4 E40K and T266M: effects on plasma triglyceride and HDL levels, postprandial responses, and CHD risk","volume":"28","author":"Talmud","year":"2008","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"2021111619115727400_B63","doi-asserted-by":"publisher","first-page":"1134","DOI":"10.1056\/NEJMoa1507652","article-title":"Coding variation in ANGPTL4, LPL, and SVEP1 and the risk of coronary disease","volume":"374","author":"Investigators","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2021111619115727400_B64","doi-asserted-by":"publisher","first-page":"634","DOI":"10.1038\/ng.3561","article-title":"Variants with large effects on blood lipids and the role of cholesterol and triglycerides in coronary disease","volume":"48","author":"Helgadottir","year":"2016","journal-title":"Nat. Genet."},{"key":"2021111619115727400_B65","doi-asserted-by":"publisher","first-page":"632","DOI":"10.1016\/j.atherosclerosis.2014.10.028","article-title":"Angiopoietin-like protein 4 significantly predicts future cardiovascular events in coronary patients","volume":"237","author":"Muendlein","year":"2014","journal-title":"Atherosclerosis"},{"key":"2021111619115727400_B66","doi-asserted-by":"publisher","first-page":"1758","DOI":"10.1038\/ng.3977","article-title":"Exome-wide association study of plasma lipids in &gt;300,000 individuals","volume":"49","author":"Liu","year":"2017","journal-title":"Nat. Genet."},{"key":"2021111619115727400_B67","doi-asserted-by":"publisher","first-page":"1123","DOI":"10.1056\/NEJMoa1510926","article-title":"Inactivating variants in ANGPTL4 and risk of coronary artery disease","volume":"374","author":"Dewey","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"2021111619115727400_B68","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.117.029733","article-title":"Inhibition of endothelial Notch signaling impairs fatty acid transport and leads to metabolic and vascular remodeling of the adult heart","author":"Jabs","year":"2018","journal-title":"Circulation"},{"key":"2021111619115727400_B69","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1038\/nm.3396","article-title":"Circulating angiopoietin-like 4 links proteinuria with hypertriglyceridemia in nephrotic syndrome","volume":"20","author":"Clement","year":"2014","journal-title":"Nat. Med."},{"key":"2021111619115727400_B70","doi-asserted-by":"publisher","first-page":"1593","DOI":"10.1038\/mt.2014.102","article-title":"Angiopoietin-like 4 stimulates STAT3-mediated iNOS expression and enhances angiogenesis to accelerate wound healing in diabetic mice","volume":"22","author":"Chong","year":"2014","journal-title":"Mol. Ther."},{"key":"2021111619115727400_B71","doi-asserted-by":"publisher","first-page":"1207","DOI":"10.1161\/01.RES.0000250758.63358.91","article-title":"Extracellular matrix-bound angiopoietin-like 4 inhibits endothelial cell adhesion, migration, and sprouting and alters actin cytoskeleton","volume":"99","author":"Cazes","year":"2006","journal-title":"Circ. Res."},{"key":"2021111619115727400_B72","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1016\/j.clim.2004.12.002","article-title":"Angiopoietin-like-4 is a potential angiogenic mediator in arthritis","volume":"115","author":"Hermann","year":"2005","journal-title":"Clin. Immunol."},{"key":"2021111619115727400_B73","doi-asserted-by":"publisher","first-page":"3030","DOI":"10.1073\/pnas.1423765112","article-title":"Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy","volume":"112","author":"Babapoor-Farrokhran","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B74","doi-asserted-by":"publisher","first-page":"2273","DOI":"10.1038\/onc.2013.174","article-title":"ANGPTL4 is a secreted tumor suppressor that inhibits angiogenesis","volume":"33","author":"Okochi-Takada","year":"2014","journal-title":"Oncogene"},{"key":"2021111619115727400_B75","doi-asserted-by":"publisher","first-page":"940","DOI":"10.1096\/fj.08-115170","article-title":"Interaction of the coiled-coil domain with glycosaminoglycans protects angiopoietin-like 4 from proteolysis and regulates its antiangiogenic activity","volume":"23","author":"Chomel","year":"2009","journal-title":"FASEB J."},{"key":"2021111619115727400_B76","doi-asserted-by":"publisher","first-page":"66","DOI":"10.1016\/j.cell.2008.01.046","article-title":"TGF\u03b2 primes breast tumors for lung metastasis seeding through angiopoietin-like 4","volume":"133","author":"Padua","year":"2008","journal-title":"Cell"},{"key":"2021111619115727400_B77","doi-asserted-by":"publisher","first-page":"E1056","DOI":"10.1152\/ajpendo.90345.2008","article-title":"Enhanced angiogenesis in obesity and in response to PPARg activators through adipocyte VEGF and ANGPTL4 production","volume":"295","author":"Gealekman","year":"2008","journal-title":"Am. J. Physiol. Endocrinol. Metab."},{"key":"2021111619115727400_B78","doi-asserted-by":"publisher","first-page":"595","DOI":"10.1038\/sj.bjp.0705494","article-title":"Using gene expression profiling to identify the molecular basis of the synergistic actions of hepatocyte growth factor and vascular endothelial growth factor in human endothelial cells","volume":"140","author":"Gerritsen","year":"2003","journal-title":"Br. J. Pharmacol."},{"key":"2021111619115727400_B79","doi-asserted-by":"publisher","first-page":"936","DOI":"10.1038\/nm884","article-title":"Role of PlGF in the intra- and intermolecular cross talk between the VEGF receptors Flt1 and Flk1","volume":"9","author":"Autiero","year":"2003","journal-title":"Nat. Med."},{"key":"2021111619115727400_B80","doi-asserted-by":"publisher","first-page":"120","DOI":"10.3892\/or.2017.5669","article-title":"Hypoxia-induced angiopoietin-like protein 4 as a clinical biomarker and treatment target for human prostate cancer","volume":"38","author":"Hata","year":"2017","journal-title":"Oncol. Rep."},{"key":"2021111619115727400_B81","doi-asserted-by":"publisher","first-page":"75778","DOI":"10.18632\/oncotarget.19018","article-title":"ANGPTL4 promotes the progression of cutaneous melanoma to brain metastasis","volume":"8","author":"Izraely","year":"2017","journal-title":"Oncotarget"},{"key":"2021111619115727400_B82","doi-asserted-by":"publisher","first-page":"75","DOI":"10.1016\/j.cyto.2017.03.006","article-title":"Angiopoietin-like protein 3 and 4 expression 4 and their serum levels in hepatocellular carcinoma","volume":"96","author":"El-Shal","year":"2017","journal-title":"Cytokine"},{"key":"2021111619115727400_B83","doi-asserted-by":"publisher","DOI":"10.1080\/16546628.2017.1338918","article-title":"Angiopoietin-like protein 4 potentiates DATS-induced inhibition of proliferation, migration, and invasion of bladder cancer EJ cells; involvement of G2\/M-phase cell cycle arrest, signaling pathways, and transcription factors-mediated MMP-9 expression","volume":"61","author":"Shin","year":"2017","journal-title":"Food Nutr. Res."},{"key":"2021111619115727400_B84","doi-asserted-by":"publisher","first-page":"1521","DOI":"10.1016\/S0002-9440(10)64285-X","article-title":"Angiopoietin-like 4 is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma","volume":"162","author":"Le","year":"2003","journal-title":"Am. J. Pathol."},{"key":"2021111619115727400_B85","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-11769-x","article-title":"Hypoxia-induced ANGPTL4 sustains tumour growth and anoikis resistance through different mechanisms in scirrhous gastric cancer cell lines","volume":"7","author":"Baba","year":"2017","journal-title":"Sci. Rep."},{"key":"2021111619115727400_B86","doi-asserted-by":"crossref","first-page":"54966","DOI":"10.18632\/oncotarget.18629","article-title":"TGF-\u03b22-induced ANGPTL4 expression promotes tumor progression and osteoclast differentiation in giant cell tumor of bone","volume":"8","author":"Li","year":"2017","journal-title":"Oncotarget"},{"key":"2021111619115727400_B87","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-19010-5","article-title":"Angiogenesis and evading immune destruction are the main related transcriptomic characteristics to the invasive process of oral tongue cancer","volume":"8","author":"P\u00e9rezvalencia","year":"2018","journal-title":"Sci. Rep."},{"key":"2021111619115727400_B88","doi-asserted-by":"publisher","first-page":"144","DOI":"10.1016\/j.archoralbio.2016.07.011","article-title":"The downregulation of ANGPTL4 inhibits the migration and proliferation of tongue squamous cell carcinoma","volume":"71","author":"Huang","year":"2016","journal-title":"Arch. Oral Biol."},{"key":"2021111619115727400_B89","doi-asserted-by":"publisher","first-page":"1525","DOI":"10.1016\/j.bbamcr.2017.06.010","article-title":"ANGPTL4 T266M variant is associated with reduced cancer invasiveness","volume":"1864","author":"Tan","year":"2017","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111619115727400_B90","doi-asserted-by":"publisher","first-page":"910","DOI":"10.1002\/hep.24479","article-title":"Hypoxia-inducible factor 1 alpha-activated angiopoietin-like protein 4 contributes to tumor metastasis via vascular cell adhesion molecule-1\/integrin \u03b21 signaling in human hepatocellular carcinoma","volume":"54","author":"Li","year":"2011","journal-title":"Hepatology"},{"key":"2021111619115727400_B91","doi-asserted-by":"publisher","first-page":"7010","DOI":"10.1158\/0008-5472.CAN-11-1262","article-title":"ANGPTL4 induction by prostaglandin E2 under hypoxic conditions promotes colorectal cancer progression","volume":"71","author":"Kim","year":"2011","journal-title":"Cancer Res."},{"key":"2021111619115727400_B92","doi-asserted-by":"publisher","first-page":"401","DOI":"10.1016\/j.ccr.2011.01.018","article-title":"Angiopoietin-like 4 protein elevates the prosurvival intracellular O:HO ratio and confers anoikis resistance to tumors","volume":"19","author":"Zhu","year":"2011","journal-title":"Cancer Cell"},{"key":"2021111619115727400_B93","doi-asserted-by":"publisher","first-page":"18721","DOI":"10.1073\/pnas.0609025103","article-title":"Angiopoietin-like 4 prevents metastasis through inhibition of vascular permeability and tumor cell motility and invasiveness","volume":"103","author":"Galaup","year":"2006","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B94","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1016\/j.devcel.2017.09.011","article-title":"Angiopoietin-like 4 is a wnt signaling antagonist that promotes LRP6 turnover","volume":"43","author":"Kirsch","year":"2017","journal-title":"Dev. Cell"},{"key":"2021111619115727400_B95","doi-asserted-by":"publisher","first-page":"128","DOI":"10.1016\/j.bbrc.2015.09.104","article-title":"Angiopoietin-like 4 enhances metastasis and inhibits apoptosis via inducing bone morphogenetic protein 7 in colorectal cancer cells","volume":"467","author":"Li","year":"2015","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111619115727400_B96","doi-asserted-by":"publisher","first-page":"14363","DOI":"10.1073\/pnas.1001065107","article-title":"Viral G protein-coupled receptor up-regulates angiopoietin-like 4 promoting angiogenesis and vascular permeability in Kaposi\u2019s sarcoma","volume":"107","author":"Ma","year":"2010","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B97","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1080\/15321819.2017.1407338","article-title":"Development of bead based multiplexed immunoassay for evaluation of midkine, syndecan-1, and ANGPTL4 in patient serum","volume":"39","author":"Tarhoni","year":"2018","journal-title":"J. Immunoassay Immunochem."},{"key":"2021111619115727400_B98","doi-asserted-by":"publisher","first-page":"3657","DOI":"10.1093\/eurheartj\/eht153","article-title":"Protective effects of angiopoietin-like 4 on cerebrovascular and functional damages in ischaemic stroke","volume":"34","author":"Bouleti","year":"2013","journal-title":"Eur. Heart J."},{"key":"2021111619115727400_B99","doi-asserted-by":"publisher","first-page":"445","DOI":"10.1055\/s-0035-1554624","article-title":"Interleukin-1beta increases Angptl4 (FIAF) expression via the JNK signaling pathway in osteoblastic MC3T3-E1 cells","volume":"123","author":"Noh","year":"2015","journal-title":"Exp. Clin. Endocrinol. Diabetes"},{"key":"2021111619115727400_B100","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.gene.2016.06.058","article-title":"Comparative analysis of gene expression profiles of hip articular cartilage between non-traumatic necrosis and osteoarthritis","volume":"591","author":"Wang","year":"2016","journal-title":"Gene"},{"key":"2021111619115727400_B101","doi-asserted-by":"publisher","first-page":"8402","DOI":"10.1074\/jbc.M113.539825","article-title":"Involvement of angiopoietin-like 4 in matrix remodeling during chondrogenic differentiation of mesenchymal stem cells","volume":"289","author":"Mathieu","year":"2014","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B102","doi-asserted-by":"publisher","first-page":"2390","DOI":"10.1002\/jcp.24969","article-title":"Silencing angiopoietin-like protein 4 (ANGPTL4) protects against lipopolysaccharide-induced acute lung injury via regulating SIRT1 \/NF-kB pathway","volume":"230","author":"Guo","year":"2015","journal-title":"J. Cell. Physiol."},{"key":"2021111619115727400_B103","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0152-2","article-title":"Angptl4 is upregulated under inflammatory conditions in the bone marrow of mice, expands myeloid progenitors, and accelerates reconstitution of platelets after myelosuppressive therapy","volume":"8","author":"Schumacher","year":"2015","journal-title":"J. Hematol. Oncol."},{"key":"2021111619115727400_B104","doi-asserted-by":"publisher","first-page":"580","DOI":"10.1016\/j.cmet.2010.11.002","article-title":"Angptl4 protects against severe proinflammatory effects of saturated fat by inhibiting fatty acid uptake into mesenteric lymph node macrophages","volume":"12","author":"Lichtenstein","year":"2010","journal-title":"Cell Metab."},{"key":"2021111619115727400_B105","doi-asserted-by":"publisher","first-page":"12313","DOI":"10.1038\/ncomms12313","article-title":"ANGPTL4 deficiency in haematopoietic cells promotes monocyte expansion and atherosclerosis progression","volume":"7","author":"Aryal","year":"2016","journal-title":"Nat. Commun."},{"key":"2021111619115727400_B106","doi-asserted-by":"publisher","first-page":"44351","DOI":"10.1038\/srep44351","article-title":"Angiopoietin-like 4 mediates colonic inflammation by regulating chemokine transcript stability via tristetraprolin","volume":"7","author":"Phua","year":"2017","journal-title":"Sci. Rep."},{"key":"2021111619115727400_B107","doi-asserted-by":"publisher","first-page":"18751","DOI":"10.1073\/pnas.0905010106","article-title":"An essential role for RPE-derived soluble VEGF in the maintenance of the Choriocapillaris","volume":"106","author":"Saint-Geniez","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B108","doi-asserted-by":"publisher","first-page":"2368","DOI":"10.1016\/j.biocel.2009.07.011","article-title":"Vascular endothelial growth factor-A: a multifunctional molecular player in diabetic retinopathy","volume":"41","author":"Zhang","year":"2009","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"2021111619115727400_B109","doi-asserted-by":"publisher","first-page":"150","DOI":"10.1016\/j.ophtha.2013.08.015","article-title":"Risk of geographic atrophy in the comparison of age-related macular degeneration treatments trials","volume":"121","author":"Grunwald","year":"2014","journal-title":"Ophthalmology"},{"key":"2021111619115727400_B110","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.1016\/j.ophtha.2013.11.029","article-title":"Intraocular pressure in eyes receiving monthly ranibizumab in 2 pivotal age-related macular degeneration clinical trials","volume":"121","author":"Bakri","year":"2014","journal-title":"Ophthalmology"},{"key":"2021111619115727400_B111","doi-asserted-by":"publisher","first-page":"31","DOI":"10.1186\/s40942-017-0084-9","article-title":"Retinal and choroidal angiogenesis: a review of new targets","volume":"3","author":"Cabral","year":"2017","journal-title":"Int. J. Retina Vitreous"},{"key":"2021111619115727400_B112","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.tem.2017.05.005","article-title":"A unified pathophysiological construct of diabetes and its complications","volume":"28","author":"Schwartz","year":"2017","journal-title":"Trends Endocrinol. Metab."},{"key":"2021111619115727400_B113","doi-asserted-by":"publisher","first-page":"556","DOI":"10.2337\/dc11-1909","article-title":"Global prevalence and major risk factors of diabetic retinopathy","volume":"35","author":"Yau","year":"2012","journal-title":"Diabetes Care"},{"key":"2021111619115727400_B114","first-page":"535","article-title":"Anti-VEGF therapy for diabetic eye diseases","volume":"6","author":"Bahrami","year":"2017","journal-title":"Asia Pac. J. Ophthalmol. (Phila.)"},{"key":"2021111619115727400_B115","doi-asserted-by":"publisher","first-page":"968","DOI":"10.1016\/j.ophtha.2015.01.007","article-title":"Aqueous levels of angiopoietin-like 4 and semaphorin 3E correlate with nonperfusion area and macular volume in diabetic retinopathy","volume":"122","author":"Kwon","year":"2015","journal-title":"Ophthalmology"},{"key":"2021111619115727400_B116","doi-asserted-by":"publisher","first-page":"1281","DOI":"10.1007\/s00417-015-3187-8","article-title":"ANGPTL-4 correlates with vascular endothelial growth factor in patients with proliferative diabetic retinopathy","volume":"254","author":"Lu","year":"2016","journal-title":"Graef. Arch. Clin. Exp. Ophthalmol."},{"key":"2021111619115727400_B117","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1016\/j.exer.2017.10.009","article-title":"ANGPTL-4 induces diabetic retinal inflammation by activating Profilin-1","volume":"166","author":"Lu","year":"2017","journal-title":"Exp. Eye Res."},{"key":"2021111619115727400_B118","doi-asserted-by":"publisher","first-page":"E3030","DOI":"10.1073\/pnas.1423765112","article-title":"Angiopoietin-like 4 is a potent angiogenic factor and a novel therapeutic target for patients with proliferative diabetic retinopathy","volume":"112","author":"Babapoor-Farrokhran","year":"2015","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619115727400_B119","doi-asserted-by":"publisher","first-page":"313e1","DOI":"10.1016\/j.ophtha.2009.07.017","article-title":"The prevalence of retinal vein occlusion: pooled data from population studies from the United States, Europe, Asia, and Australia","volume":"117","author":"Rogers","year":"2010","journal-title":"Ophthalmology"},{"key":"2021111619115727400_B120","first-page":"6","article-title":"Aqueous angiopoietin-like 4 levels correlate with nonperfusion area and macular edema in branch retinal vein occlusion","volume":"57","author":"Kim","year":"2016","journal-title":"Investig. Ophthalmol. Vis. Sci."},{"key":"2021111619115727400_B121","doi-asserted-by":"publisher","first-page":"e122","DOI":"10.1016\/j.jcjo.2017.01.010","article-title":"Expression of angiogenic mediators in a patient with a retinal artery occlusion","volume":"52","author":"Babapoor-Farrokhran","year":"2017","journal-title":"Can. J. Ophthalmol."},{"key":"2021111619115727400_B122","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1016\/j.oret.2017.03.015","article-title":"Machine learning to analyze the prognostic value of current imaging biomarkers in neovascular age-related macular degeneration","volume":"2","author":"Schmidt-Erfurth","year":"2018","journal-title":"Ophthalmol. Retina"},{"key":"2021111619115727400_B123","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00417-017-3846-z","article-title":"Plasma levels of hypoxia-regulated factors in patients with age-related macular degeneration","volume":"256","author":"Ioanna","year":"2018","journal-title":"Graefes Arch. Clin. Exp. Ophthalmol."},{"key":"2021111619115727400_B124","doi-asserted-by":"publisher","first-page":"523","DOI":"10.1097\/IAE.0000000000001554","article-title":"Angiopoietin-like 4 correlates with response to intravitreal ranibizumab injections in neovascular age-related macular degeneration","volume":"38","author":"Kim","year":"2018","journal-title":"Retina"},{"key":"2021111619115727400_B125","doi-asserted-by":"publisher","first-page":"335","DOI":"10.2147\/JMDH.S90630","article-title":"Sickle cell retinopathy: improving care with a multidisciplinary approach","volume":"10","author":"Menaa","year":"2017","journal-title":"J. Multidiscip. Healthcare"},{"key":"2021111619115727400_B126","doi-asserted-by":"publisher","first-page":"e0183320","DOI":"10.1371\/journal.pone.0183320","article-title":"Expression of the angiogenic mediator, angiopoietin-like 4, in the eyes of patients with proliferative sickle retinopathy","volume":"12","author":"Jee","year":"2017","journal-title":"PLoS ONE"},{"key":"2021111619115727400_B127","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jtos.2014.01.001","article-title":"Surgical management of pterygium","volume":"12","author":"Janson","year":"2014","journal-title":"Ocular Surface"},{"key":"2021111619115727400_B128","first-page":"4514","article-title":"Hypoxia-inducible factor-dependent expression of angiopoietin-like 4 by conjunctival epithelial cells promotes the angiogenic phenotype of pterygia","volume":"58","author":"Meng","year":"2017","journal-title":"Invest. Ophthalmol. Vis. Sci."},{"key":"2021111619115727400_B129","doi-asserted-by":"publisher","first-page":"1881","DOI":"10.1016\/j.ophtha.2011.01.040","article-title":"Uveal melanoma: trends in incidence, treatment, and survival","volume":"118","author":"Singh","year":"2011","journal-title":"Ophthalmology"},{"key":"2021111619115727400_B130","doi-asserted-by":"crossref","first-page":"7816","DOI":"10.18632\/oncotarget.6868","article-title":"Hypoxia-inducible factor 1 upregulation of both VEGF and ANGPTL4 is required to promote the angiogenic phenotype in uveal melanoma","volume":"7","author":"Hu","year":"2016","journal-title":"Oncotarget"},{"key":"2021111619115727400_B131","first-page":"680","article-title":"Multicellular tumor spheroids of human uveal melanoma induce genes associated with anoikis resistance, lipogenesis, and SSXs","volume":"23","author":"Ness","year":"2017","journal-title":"Mol. Vis."},{"key":"2021111619115727400_B132","first-page":"245","article-title":"Hypoxia-driven angiogenesis: role of tip cells and extracellular matrix scaffolding","volume":"17","author":"Germain","year":"2010","journal-title":"Curr. Opin. Hematol."},{"key":"2021111619115727400_B133","first-page":"6651","article-title":"Inhibition of angiogenesis and vascular leakiness by angiopoietin-related protein 4","volume":"63","author":"Ito","year":"2003","journal-title":"Cancer Res."},{"key":"2021111619115727400_B134","doi-asserted-by":"publisher","first-page":"36841","DOI":"10.1074\/jbc.M111.220061","article-title":"Alteration of developmental and pathological retinal angiogenesis in angptl4-deficient mice","volume":"286","author":"Perdiguero","year":"2011","journal-title":"J. Biol. Chem."},{"key":"2021111619115727400_B135","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.ijcard.2017.10.054","article-title":"Therapeutic antagonism of ANGPTL4","volume":"256","author":"Luo","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"2021111619115727400_B136","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1016\/j.ijcard.2017.10.123","article-title":"ANGPTL4, a multifaceted protein at the cross-talk between metabolism and cardiovascular disorders","volume":"256","author":"Bouleti","year":"2018","journal-title":"Int. J. Cardiol."},{"key":"2021111619115727400_B137","doi-asserted-by":"publisher","first-page":"654","DOI":"10.1016\/j.celrep.2015.01.011","article-title":"Angiopoietin-like 4 increases pulmonary tissue leakiness and damage during influenza pneumonia","volume":"10","author":"Li","year":"2015","journal-title":"Cell Rep."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20180557\/809284\/bsr-2018-0557.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20180557\/809284\/bsr-2018-0557.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:08:23Z","timestamp":1637093303000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/38\/5\/BSR20180557\/87770\/A-review-of-the-multifunctionality-of-angiopoietin"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,9,14]]},"references-count":137,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20180557","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,9,14]]},"article-number":"BSR20180557"}}