{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T12:01:00Z","timestamp":1779278460127,"version":"3.51.4"},"reference-count":22,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":281,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>Missed abortion is one of the common complications of assisted reproductive technology (ART). Genetic abnormality is the most important factor. However, the effect of ART on the molecular karyotype of products of conception (POC) remains unknown. We explored the effect of ART on the molecular karyotype of POC in miscarriage. POC were obtained from women undergoing ART. Single nucleotide polymorphism (SNP) microarray was used to analyze the molecular karyotype. A total of 1493 POC were collected for SNP array analysis. The total rate of karyotypic abnormalities was 63.1% (943\/1493). The proportion of karyotypic abnormalities was 70.4% (193\/416) in &amp;gt;35-year-old group, which was significantly higher than that (60.6%) (343\/566) in &amp;lt;30-year-old group and that (60%) (307\/511) in the 30\u201335-year-old group. In natural conception (NC) group, the proportion of karyotypic abnormalities was 64.6% (201\/311), whereas in ART group it was 62.7% (742\/1182) and, there was no significant difference. The ratio between male and female fetuses was 1:1.13 (698\/795). The rate of karyotypic abnormalities in male was 62.9% (439\/698) and that in female was 63.4% (504\/795), and these values did not differ significantly (P=0.84). Molecular karyotypic abnormality is the most important reason in miscarriage, and female age is a significant factor influencing the karyotypic abnormalities. Comparison with NC, ART, and gender of aborted embryos may not increase the rate of molecular karyotypic abnormality in miscarriage.<\/jats:p>","DOI":"10.1042\/bsr20180605","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T12:35:14Z","timestamp":1535027714000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of assisted reproductive technology on the molecular karyotype of missed abortion tissues"],"prefix":"10.1042","volume":"38","author":[{"given":"Gang","family":"Li","sequence":"first","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haixia","family":"Jin","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenbin","family":"Niu","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawei","family":"Xu","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yihong","family":"Guo","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingchun","family":"Su","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yingpu","family":"Sun","sequence":"additional","affiliation":[{"name":"Reproductive Medical Center, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,10,17]]},"reference":[{"key":"2021111619143200800_B1","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1016\/j.ajhg.2010.04.006","article-title":"Consensus statement: chromosomal microarray is a first-tier clinical diagnostic test for individuals with developmental disabilities or congenital anomalies","volume":"86","author":"Miller","year":"2010","journal-title":"Am. J. Hum. Genet."},{"key":"2021111619143200800_B2","doi-asserted-by":"publisher","first-page":"1708","DOI":"10.1136\/bmj.320.7251.1708","article-title":"Maternal age and fetal loss: population based register linkage study","volume":"320","author":"Nybo Andersen","year":"2000","journal-title":"BMJ"},{"key":"2021111619143200800_B3","first-page":"959","article-title":"Spontaneous abortion among pregnancies conceived using assisted reproductive technology in the United States","volume":"101","author":"Schieve","year":"2003","journal-title":"Obstet. Gynecol."},{"key":"2021111619143200800_B4","doi-asserted-by":"publisher","first-page":"252","DOI":"10.1055\/s-2007-999587","article-title":"The wider perinatal significance of the Australian in vitro fertilization data collection program","volume":"6","author":"Saunders","year":"1989","journal-title":"Am. J. Perinatol."},{"key":"2021111619143200800_B5","doi-asserted-by":"publisher","first-page":"1218","DOI":"10.1093\/humrep\/deu053","article-title":"Association between response to ovarian stimulation and miscarriage following IVF: an analysis of 124 351 IVF pregnancies","volume":"29","author":"Sunkara","year":"2014","journal-title":"Hum. Reprod."},{"key":"2021111619143200800_B6","doi-asserted-by":"publisher","first-page":"272","DOI":"10.1093\/humrep\/deh078","article-title":"Incidence of spontaneous abortion among pregnancies produced by assisted reproductive technology","volume":"19","author":"Wang","year":"2004","journal-title":"Hum. Reprod."},{"key":"2021111619143200800_B7","doi-asserted-by":"publisher","first-page":"227","DOI":"10.3109\/19396368.2012.750696","article-title":"Molecular karyotype single nucleotide polymorphism analysis of early fetal demise","volume":"59","author":"Li","year":"2013","journal-title":"Syst. Biol. Reprod. Med."},{"issue":"29 Suppl. B","key":"2021111619143200800_B8","doi-asserted-by":"publisher","first-page":"S126","DOI":"10.1016\/j.placenta.2008.08.015","article-title":"Chromosomal abnormalities in miscarriages after different assisted reproduction procedures","volume":"29","author":"Bettio","year":"2008","journal-title":"Placenta"},{"key":"2021111619143200800_B9","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/1471-2350-11-153","article-title":"Chromosomal abnormalities in spontaneous abortion after assisted reproductive treatment","volume":"11","author":"Kim","year":"2010","journal-title":"BMC Med. Genet."},{"key":"2021111619143200800_B10","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1007\/s10815-011-9646-1","article-title":"Comparison of chromosomal abnormality rates in ICSI for non-male factor and spontaneous conception","volume":"29","author":"Bingol","year":"2012","journal-title":"J. Assist. Reprod. Genet."},{"key":"2021111619143200800_B11","doi-asserted-by":"publisher","first-page":"1270","DOI":"10.1016\/j.fertnstert.2003.09.065","article-title":"Rate of aneuploidy in miscarriages following in vitro fertilization and intracytoplasmic sperm injection","volume":"81","author":"Lathi","year":"2004","journal-title":"Fertil. Steril."},{"key":"2021111619143200800_B12","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s10815-009-9292-z","article-title":"Aneuploidy in abortuses following IVF and ICSI","volume":"26","author":"Kushnir","year":"2009","journal-title":"J. Assist. Reprod. Genet."},{"key":"2021111619143200800_B13","doi-asserted-by":"publisher","first-page":"83","DOI":"10.1038\/gim.2016.69","article-title":"Comprehensive genetic analysis of pregnancy loss by chromosomal microarrays: outcomes, benefits, and challenges","volume":"19","author":"Sahoo","year":"2017","journal-title":"Genet. Med."},{"key":"2021111619143200800_B14","doi-asserted-by":"publisher","first-page":"1122","DOI":"10.1016\/j.fertnstert.2017.03.011","article-title":"In vitro fertilization with preimplantation genetic diagnosis for aneuploidies in advanced maternal age: a randomized, controlled study","volume":"107","author":"Rubio","year":"2017","journal-title":"Fertil. Steril."},{"key":"2021111619143200800_B15","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1016\/j.fertnstert.2017.03.007","article-title":"Preimplantation genetic diagnosis for aneuploidy testing in women older than 44 years: a multicenter experience","volume":"107","author":"Ubaldi","year":"2017","journal-title":"Fertil. Steril."},{"key":"2021111619143200800_B16","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1111\/j.1600-0897.2004.00196.x","article-title":"Cytogenetic abnormalities in products of conception:a relationship revisited","volume":"52","author":"Yusuf","year":"2004","journal-title":"Am. J. Reprod. Immunol."},{"key":"2021111619143200800_B17","doi-asserted-by":"crossref","first-page":"e1","DOI":"10.1016\/j.ajog.2006.12.012","article-title":"Recurrent spontaneous abortion and skewed X-inactivation: is there an association","volume":"196","author":"Hogge","year":"2007","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021111619143200800_B18","doi-asserted-by":"publisher","first-page":"56","DOI":"10.1186\/1477-7827-12-56","article-title":"Changes in sex ratio from fertilization to birth in assisted-reproductive-treatment cycles","volume":"12","author":"Tar\u00edn","year":"2014","journal-title":"Reprod. Biol. Endocrinol."},{"key":"2021111619143200800_B19","doi-asserted-by":"publisher","first-page":"e0170403","DOI":"10.1371\/journal.pone.0170403","article-title":"Embryonic loss of human females with partial trisomy 19 identifies region critical for the single active X","volume":"12","author":"Migeon","year":"2017","journal-title":"PLoS ONE"},{"key":"2021111619143200800_B20","doi-asserted-by":"publisher","first-page":"563","DOI":"10.1067\/mob.2001.117670","article-title":"A novel X chromosome-linked genetic cause of recurrent spontaneous abortion","volume":"185","author":"Lanasa","year":"2001","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021111619143200800_B21","doi-asserted-by":"publisher","first-page":"1059","DOI":"10.1007\/s10815-014-0261-9","article-title":"Chromosome distribution of early miscarriages with present or absent embryos: female predominance","volume":"31","author":"Cheng","year":"2004","journal-title":"J. Assist. Reprod. Genet."},{"key":"2021111619143200800_B22","doi-asserted-by":"publisher","first-page":"527","DOI":"10.2217\/WHE.15.19","article-title":"Infertility and miscarriage: common pathways in manifestation and management","volume":"11","author":"Agenor","year":"2015","journal-title":"Womens Health (Lond.)"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20180605\/810253\/bsr-2018-0605-t.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20180605\/810253\/bsr-2018-0605-t.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:12:03Z","timestamp":1637093523000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/38\/5\/BSR20180605\/88603\/Effect-of-assisted-reproductive-technology-on-the"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2018,10,17]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2018,10,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20180605","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,10,17]]},"article-number":"BSR20180605"}}