{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T12:59:03Z","timestamp":1788785943370,"version":"build-2803163510"},"reference-count":35,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":252,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,21]]},"abstract":"<jats:p>Background: The prevalence of coronary heart disease (CHD) appears to be high among Chinese Mongolians. MiR-23b has been proven to play a key role in atherosclerosis. The expression and role of miR-23b in the Mongolians at high cardiovascular risk were explored in the present study.<\/jats:p>\n               <jats:p>Methods: Forty cases of blood samples from the Mongolians at high cardiovascular risk were enrolled in the present study. The expression of miR-23b was quantified by quantitative real-time PCR. To induce monocytes differentiation into macrophages, HP-1 cells were cultured with phorbol 12-myristate 13-acetate. The level of inflammatory markers was determined by the enzyme-linked immunosorbent assay. The interaction between miR-23b and A20 was explored by the dual luciferase reporter assay.<\/jats:p>\n               <jats:p>Results: The expression of miR-23b in the Mongolian at high cardiovascular risk was higher than that in healthy Mongolian volunteers. Decrease in ATP-binding cassette transporter A1 caused by miR-23b is responsible for TC accumulation in the Mongolian at high cardiovascular risk. MiR-23b enhanced the oxidized low-density lipoprotein (oxLDL)-induced inflammatory response of THP-1 derived macrophage. MiR-23b regulated nuclear factor-\u03baB (NF-\u03baB) pathway through targeting A20. MiR-23b mediated oxLDL-induced inflammatory response of peripheral blood mononuclear cell in the Mongolian at high cardiovascular risk.<\/jats:p>\n               <jats:p>Conclusion MiR-23b enhanced oxLDL-induced inflammatory response of macrophages in the Mongolian at high cardiovascular risk through the A20\/NF-\u03baB signaling pathway, and thus contributing to atherosclerosis.<\/jats:p>","DOI":"10.1042\/bsr20180673","type":"journal-article","created":{"date-parts":[[2018,10,12]],"date-time":"2018-10-12T12:55:52Z","timestamp":1539348952000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Abnormally expressed miR-23b in Chinese Mongolian at high cardiovascular risk may contribute to monocyte\/macrophage inflammatory reaction in atherosclerosis"],"prefix":"10.1042","volume":"38","author":[{"given":"Li-ping","family":"He","sequence":"first","affiliation":[{"name":"Department of Cardiology, Inner Mongolia People\u2019s Hospital, Huhhot 010020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xing-sheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inner Mongolia People\u2019s Hospital, Huhhot 010020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Le-ping","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Inner Mongolia People\u2019s Hospital, Huhhot 010020, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,11,16]]},"reference":[{"key":"2021111619194066900_B1","doi-asserted-by":"publisher","first-page":"807","DOI":"10.1016\/j.amjmed.2014.04.015","article-title":"The epidemic of the 20(th) century: coronary heart disease","volume":"127","author":"Dalen","year":"2014","journal-title":"Am. 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