{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:08:14Z","timestamp":1787004494246,"version":"build-2736575974"},"reference-count":39,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":231,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,21]]},"abstract":"<jats:p>The present study was designed to investigate the use of specific biomarkers, such as albumin, serum total protein, aspartate amino transferase (AST), globulin, alanine amino transferase (ALT), serum cortisol and alkaline phosphatase (ALP), as predictive tools for sarcoptic mange in rabbits. A total of 40 naturally infested rabbits were equally divided into four groups.Thirty infested rabbits were administered with three different treatments (propolis,ivermectin, and propolis with ivermectin) and were compared to10 infested un-treated rabbits. The impact of treatment was assessed via microscopic examination of skin scrapings, clinical signs, and blood measurements relating to the liver. The present study demonstrated that topical application of 10% propolis ointment resulted in complete recovery from clinical signs and complete absence of mites based on microscopic examination after 10\u201315 days of treatment. Moreover, AST, ALP, ALT, and cortisol were determined to be acceptable biomarkers to track the response of diseased rabbits to the therapeutic use of propolis.<\/jats:p>","DOI":"10.1042\/bsr20180874","type":"journal-article","created":{"date-parts":[[2018,10,5]],"date-time":"2018-10-05T07:51:44Z","timestamp":1538725904000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Biomarkers as predictive tools to test the\n                    <i>in vivo<\/i>\n                    anti-sarcoptic mange activity of propolis in naturally infested rabbits"],"prefix":"10.1042","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0595-0609","authenticated-orcid":false,"given":"Dina\u00a0M.","family":"Metwally","sequence":"first","affiliation":[{"name":"Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia"},{"name":"Department of Parasitology, Faculty of Veterinary Medicine, Zagazig University, Zagazig, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ebtesam\u00a0M.","family":"Al-Olayan","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reem\u00a0A.","family":"Alshalhoop","sequence":"additional","affiliation":[{"name":"Department of Zoology, Faculty of Science, King Saud University, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shatha\u00a0A.","family":"Eisa","sequence":"additional","affiliation":[{"name":"National Health Laboratory, Riyadh, Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,12,7]]},"reference":[{"key":"2021111619223614400_B1","doi-asserted-by":"publisher","first-page":"1415","DOI":"10.1016\/B978-0-7216-7618-0.50025-0","article-title":"Dermatoses of pet rodents, rabbits and ferrets.","volume-title":"Muller and Kirkc Small Animal Dermatology","author":"Scott","year":"2001"},{"key":"2021111619223614400_B2","first-page":"1","article-title":"Investigating the anti-sarcoptic mange activity (in vivo) of propolis ointment in naturally infested rabbits","volume":"28","author":"Metwally","year":"2017","journal-title":"Biomed. 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