{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T21:32:43Z","timestamp":1757539963379,"version":"3.41.2"},"reference-count":32,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,7,25]],"date-time":"2019-07-25T00:00:00Z","timestamp":1564012800000},"content-version":"vor","delay-in-days":314,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,10,31]]},"abstract":"<jats:p>XPG gene contributes to DNA repair defects and genomic instability, which may lead to the initiation of uterine leiomyoma. We hypothesized that genetic variants of XPG gene may alter the carriers\u2019 susceptibility to leiomyoma. The association between five potential functional single nucleotide polymorphisms (SNPs), i.e. rs2094258 C&amp;gt;T, rs751402 C&amp;gt;T, rs2296147 T&amp;gt;C, rs1047768 T&amp;gt;C, rs873601 G&amp;gt;A, and uterine leiomyoma risk in Chinese, was investigated in this case\u2013control study, which included 398 incident leiomyoma cases and 733 controls. We found that rs873601 was significantly associated with tumor risk in a recessive genetic model after being adjusting for age and menopause. When compared with rs873601 GG\/GA genotypes, the AA genotype had an increased leiomyoma risk (adjusted OR = 1.59, 95% CI = 1.16\u20132.18, P=0.004; Bonferroni adjusted P=0.040). Furthermore, stratified analysis revealed that the association between the rs873601 AA genotype and leiomyoma risk was more evident among subjects younger than 40 years old (adjusted OR = 1.58, 95% CI = 1.06\u20132.35, P=0.023) and patients who had more than three myomas (adjusted OR = 2.05, 95% CI = 1.24\u20133.41, P=0.006). Yet, no significant association between the other four polymorphisms and leiomyoma risk was observed. To sum up, the present study reported on the association between XPG gene polymorphisms and myoma risk. The observed data indicated that SNP rs873601 G&amp;gt;A contributes to uterine leiomyoma susceptibility in a Southern Chinese population.<\/jats:p>","DOI":"10.1042\/bsr20181116","type":"journal-article","created":{"date-parts":[[2018,8,23]],"date-time":"2018-08-23T12:35:14Z","timestamp":1535027714000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<i>XPG<\/i> rs873601 G&amp;gt;A contributes to uterine leiomyoma susceptibility in a Southern Chinese population"],"prefix":"10.1042","volume":"38","author":[{"given":"Zhi-Qin","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guan-Ge","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Second Affiliated Hospital and Yuying Children\u2019s Hospital of Wenzhou Medical University, Wenzhou 325027, Zhejiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ru-Liang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bao\u2019an Maternal and Child Health Hospital, to Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chao","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Yin","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Biobank, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lan-Fang","family":"Guan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Ling","family":"Chi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"You-Qiang","family":"Jian","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rui-Qi","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Yu","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bao\u2019an Maternal and Child Health Hospital, to Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fang-Fang","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Pathology, Bao\u2019an Maternal and Child Health Hospital, to Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Biobank, Bao\u2019an Maternal and Child Health Hospital, Jinan University, Shenzhen 518102, Guangdong, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2018,9,14]]},"reference":[{"key":"2021111619143134800_B1","doi-asserted-by":"publisher","first-page":"16043","DOI":"10.1038\/nrdp.2016.43","article-title":"Uterine fibroids","volume":"2","author":"Stewart","year":"2016","journal-title":"Nat. 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