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Immunization assays with SGSTF reduced up to 90% of the parasitic load in a murine model of cysticercosis. It prompted us to investigate how SGSTF induces this protective immune response. To test it, we exposed peritoneal macrophages to SGSTF for 24 h; such exposure favored the production of IL-12, TNF, and IL-10 as well as the expression of nitric oxide synthase 2 inducible (Nos2) and CD86, but did not induce the expression of chitinase-like 3 (Chil3). Confocal microscopy showed that the macrophages internalize the SGSTF which co-localized after 1 h with MHC-II in their plasma membranes. Macrophages exposed to SGSTF and co-cultured with anti-CD3 pre-activated T CD4+ cells, enhanced the proliferation of CD4+ cells, induced high interferon-\u03b3 (IFN-\u03b3) secretion, and elevated the expression of CD25 and CD69, molecules associated with cell activation. Similar assay using T CD4+ cells from DO11.10 mice and ovalbumin (OVA) peptide+SGSTF as stimuli, showed enhanced cell proliferation and OVA-specific IFN-\u03b3 secretion. These data are in-line with those indicating that the P1, P5, and P6 peptides of Schistosoma japonicum 28GST highly promote T-cell proliferation and Th1 response in vitro. We found that such peptides are also present on Ts25GST and Ts26GST. It suggests that SGSTF activates peritoneal macrophages to a classically activated-like phenotype, and that these macrophages induce the differentiation of T CD4+ cells toward a Th1-type response.<\/jats:p>","DOI":"10.1042\/bsr20181132","type":"journal-article","created":{"date-parts":[[2018,12,11]],"date-time":"2018-12-11T17:05:35Z","timestamp":1544547935000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["<i>Taenia solium<\/i> glutathione transferase fraction activates macrophages and favors the development of Th1-type response"],"prefix":"10.1042","volume":"39","author":[{"given":"Vera\u00a0Teresa","family":"Vega-Angeles","sequence":"first","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico 04510, CDMX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luis\u00a0I.","family":"Terrazas","sequence":"additional","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla, Estado de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yadira","family":"Ledesma-Soto","sequence":"additional","affiliation":[{"name":"Unidad de Biomedicina, Facultad de Estudios Superiores Iztacala, Universidad Nacional Aut\u00f3noma de M\u00e9xico, Tlalnepantla, Estado de M\u00e9xico, M\u00e9xico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luc\u00eda","family":"Jim\u00e9nez","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico 04510, CDMX"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2573-1806","authenticated-orcid":false,"given":"Abraham","family":"Landa","sequence":"additional","affiliation":[{"name":"Departamento de Microbiolog\u00eda y Parasitolog\u00eda, Facultad de Medicina, Universidad Nacional Aut\u00f3noma de M\u00e9xico, M\u00e9xico 04510, CDMX"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,1,18]]},"reference":[{"key":"2021111617021357400_B1","doi-asserted-by":"publisher","first-page":"1202","DOI":"10.1016\/S1474-4422(14)70094-8","article-title":"Clinical symptoms, diagnosis, and treatment of neurocysticercosis","volume":"13","author":"Garcia","year":"2014","journal-title":"Lancet Neurol."},{"issue":"46","key":"2021111617021357400_B2","first-page":"630","article-title":"Fact sheet on taeniasis\/cysticercosis (updated February 2018)","volume":"93","author":"World Health Organization","year":"2018","journal-title":"Weekly Epidemiological record"},{"key":"2021111617021357400_B3","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1590\/S0004-282X2012000400002","article-title":"Cysticercosis and the immunossupression: what are the mechanisms involved?","volume":"70","author":"Bueno","year":"2012","journal-title":"Arq. 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