{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:37:21Z","timestamp":1753871841702,"version":"3.41.2"},"reference-count":27,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,7,18]],"date-time":"2019-07-18T00:00:00Z","timestamp":1563408000000},"content-version":"vor","delay-in-days":198,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We observed inconsistent conclusions regarding the genetic role of glutathione S-transferase gene polymorphisms, including glutathione S-transferase M1 (GSTM1), glutathione S-transferase T1 (GSTT1) present\/null, and glutathione S-transferase pi (GSTP1) Ile105Val polymorphisms, in the susceptibility to nasal or colorectal polyposis (NP or CP). Thus, we aimed to perform a meta-analysis to comprehensively evaluate this association by applying Stata\/SE software. After the heterogeneity assumption, Mantel\u2013Haenszel statistics were used to obtain the odds ratio (OR), 95% confidence interval (95% CI) and P-value of the association test (PA). We obtained a total of 235 articles by searching online databases. After screening, ten eligible case\u2013control studies were finally enrolled in our meta-analysis. For the meta-analysis of the GSTT1 gene under present versus null, we observed a decreased risk of NP [OR = 0.65; PA=0.018], but not CP. In addition, we did not detect any evident association between the GSTM1 present\/null polymorphism and NP or CP risk. For the meta-analysis of the GSTP1 Ile105Val polymorphism, compared with controls, an increased risk of NP cases was detected under the models of Val versus Ile (OR = 1.36; PA=0.027), Ile\/Val versus Ile\/Ile (OR = 1.70; PA=0.011) and Ile\/Val+Val\/Val versus Ile\/Ile (OR = 1.65; PA=0.010). In conclusion, the null genotype of the GSTT1 polymorphism may be linked to an increased susceptibility to NP, whereas the Ile\/Val genotype of the GSTP1 Ile105Val polymorphism may be associated with a decreased risk of NP.<\/jats:p>","DOI":"10.1042\/bsr20181226","type":"journal-article","created":{"date-parts":[[2019,1,7]],"date-time":"2019-01-07T17:37:37Z","timestamp":1546882657000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Glutathione S-transferase gene polymorphisms and risk of nasal or colorectal polyposis"],"prefix":"10.1042","volume":"39","author":[{"given":"Yonglan","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Tianjin 300192, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haichao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery, Tianjin 4th Center Hospital, Tianjin 300140, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peng","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Tianjin 300192, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9042-4015","authenticated-orcid":false,"given":"Guimin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Tianjin First Center Hospital, Tianjin 300192, People\u2019s Republic of China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2019,1,25]]},"reference":[{"key":"2021111617035019100_B1","doi-asserted-by":"publisher","first-page":"9","DOI":"10.2500\/aap.2018.39.4101","article-title":"Chronic rhinosinusitis with nasal polyps in the elderly: assessing current evidence","volume":"39","author":"Marioni","year":"2018","journal-title":"Allergy Asthma Proc."},{"key":"2021111617035019100_B2","doi-asserted-by":"publisher","first-page":"409","DOI":"10.1016\/j.bpg.2017.05.011","article-title":"Hereditary or sporadic polyposis syndromes","volume":"31","author":"Basso","year":"2017","journal-title":"Best Pract. 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