{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T03:25:23Z","timestamp":1775186723804,"version":"3.50.1"},"reference-count":24,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":220,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>This meta-analysis was performed in order to determine the associations between the estrogen receptor \u03b1 (ESR1) gene PvuII site (-397T\/C, rs2234693) and XbaI site (-351A\/G, rs9340799) polymorphisms with severe and mild pre-eclampsia. Eligible studies were identified by searching PubMed, Medline, Embase, China National Knowledge Infrastructure (CNKI), and WanFang databases until May 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were used to calculate the associations. Six articles (consisting of seven studies; one article was considered as two separate studies with two different subpopulations) investigated the ESR1 gene PvuII -397T\/C and XbaI -351A\/G polymorphisms in severe and mild pre-eclampsia patients and included controls. The pooled results indicated an increased risk of severe pre-eclampsia for the XbaI -351A\/G polymorphism (OR = 1.67, 95% CI = 1.10\u20132.25, P=0.017 for GG compared with AA+GA; OR = 1.81, 95% CI = 1.17\u20132.82, P=0.008 for GG compared with GA). The GG genotype of the ESR1 XbaI polymorphism could be a genetic risk factor for severe pre-eclampsia susceptibility. However, the ESR1 gene PvuII -397T\/C polymorphism was not significantly associated with the risk of severe pre-eclampsia, and there was no association between mild pre-eclampsia and the ESR1 gene PvuII -397T\/C and XbaI -351A\/G polymorphisms separately. The current meta-analysis indicates that the ESR1 XbaI genetic polymorphism may be associated with severe pre-eclampsia. However, there was no association of the ESR1 gene PvuII and XbaI polymorphisms with the risk of mild pre-eclampsia. Owing to the low statistical power, the results may not be sufficiently robust and this conclusion should be interpreted cautiously, which highlights the requirement for large-scale and high-quality studies in this field.<\/jats:p>","DOI":"10.1042\/bsr20181548","type":"journal-article","created":{"date-parts":[[2019,1,10]],"date-time":"2019-01-10T19:45:11Z","timestamp":1547149511000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Association between the estrogen receptor \u03b1 gene polymorphisms rs2234693 and rs9340799 and severe and mild pre-eclampsia: a meta-analysis"],"prefix":"10.1042","volume":"39","author":[{"given":"Ge","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yunfei","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Dermatology, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jing","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5932-8364","authenticated-orcid":false,"given":"Tao","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, The First Hospital of China Medical University, No. 155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. 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