{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T20:58:52Z","timestamp":1793134732067,"version":"4.5.0"},"reference-count":74,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2019,9,9]],"date-time":"2019-09-09T00:00:00Z","timestamp":1567987200000},"content-version":"vor","delay-in-days":192,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,3,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>There is a strong association between periodontal disease and atherosclerotic cardiovascular disorders. A key event in the development of atherosclerosis is accumulation of modified lipoproteins within the arterial wall. We hypothesise that patients with periodontitis have an altered lipoprotein profile towards an atherogenic form. Therefore, the present study aims at identifying modifications of plasma lipoproteins in periodontitis. Lipoproteins from ten female patients with periodontitis and gender- and age-matched healthy controls were isolated by density-gradient ultracentrifugation. Proteins were separated by 2D gel-electrophoresis and identified by map-matching or by nano-LC followed by MS. Apolipoprotein (Apo) A-I (ApoA-I) methionine oxidation, Oxyblot, total antioxidant capacity and a multiplex of 71 inflammation-related plasma proteins were assessed. Reduced levels of apoJ, phospholipid transfer protein, apoF, complement C3, paraoxonase 3 and increased levels of \u03b1-1-antichymotrypsin, apoA-II, apoC-III were found in high-density lipoprotein (HDL) from the patients. In low-density lipoprotein (LDL)\/very LDL (VLDL), the levels of apoL-1 and platelet-activating factor acetylhydrolase (PAF-AH) as well as apo-B fragments were increased. Methionine oxidation of apoA-I was increased in HDL and showed a relationship with periodontal parameters. \u03b1-1 antitrypsin and \u03b1-2-HS glycoprotein were oxidised in LDL\/VLDL and antioxidant capacity was increased in the patient group. A total of 17 inflammation-related proteins were important for group separation with the highest discriminating proteins identified as IL-21, Fractalkine, IL-17F, IL-7, IL-1RA and IL-2. Patients with periodontitis have an altered plasma lipoprotein profile, defined by altered protein levels as well as post-translational and other structural modifications towards an atherogenic form, which supports a role of modified plasma lipoproteins as central in the link between periodontal and cardiovascular disease (CVD).<\/jats:p>","DOI":"10.1042\/bsr20181665","type":"journal-article","created":{"date-parts":[[2019,3,6]],"date-time":"2019-03-06T17:25:27Z","timestamp":1551893127000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":30,"title":["Modified lipoproteins in periodontitis: a link to cardiovascular disease?"],"prefix":"10.1042","volume":"39","author":[{"given":"Stefan","family":"Ljunggren","sequence":"first","affiliation":[{"name":"Occupational and Environmental Medicine Center, and Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Torbj\u00f6rn","family":"Bengtsson","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Karlsson","sequence":"additional","affiliation":[{"name":"Occupational and Environmental Medicine Center, and Department of Clinical and Experimental Medicine, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carin","family":"Starkhammar Johansson","sequence":"additional","affiliation":[{"name":"Centre for Oral Rehabilitation, Public Dental Health Care, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eleonor","family":"Palm","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fariba","family":"Nayeri","sequence":"additional","affiliation":[{"name":"PEAS Research Institute, Department of Infection Control, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bijar","family":"Ghafouri","sequence":"additional","affiliation":[{"name":"Pain and Rehabilitation Centre, and Department of Medical and Health Sciences, Link\u00f6ping University, Link\u00f6ping, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Davies","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Odontology, Malm\u00f6 University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunnel","family":"Svens\u00e4ter","sequence":"additional","affiliation":[{"name":"Department of Oral Biology, Faculty of Odontology, Malm\u00f6 University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5242-7773","authenticated-orcid":false,"given":"Johanna","family":"L\u00f6nn","sequence":"additional","affiliation":[{"name":"Department of Medical Sciences, \u00d6rebro University, \u00d6rebro, Sweden"},{"name":"PEAS Research Institute, Department of Infection Control, Link\u00f6ping, Sweden"},{"name":"Department of Oral Biology, Faculty of Odontology, Malm\u00f6 University, Malm\u00f6, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,3,26]]},"reference":[{"key":"2021111619305139300_B1","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1016\/j.yexmp.2016.01.006","article-title":"Links between atherosclerotic and periodontal disease","volume":"100","author":"Chistiakov","year":"2016","journal-title":"Exp. 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