{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T10:37:29Z","timestamp":1753871849888,"version":"3.41.2"},"reference-count":37,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":141,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Association between the xeroderma pigmentosum complementation group F (XPF)rs2276466 located in the excision repair cross complementation group 4 (ERCC4) gene and cancer susceptibility has been widely investigated. However, results thus far have remained controversial. A meta-analysis was performed to identify the impact of this polymorphism on cancer susceptibility. PubMed, Embase and Science-Web databases were searched systematically up to May 20, 2018, to obtain all the records evaluating the association between the rs2276466 polymorphism and the risk of all types of cancers. We used the odds ratio (OR) as a measure of effect, and pooled the data in a Mantel-Haenszel weighed random-effects meta-analysis to provide a summary estimate of the impact of this polymorphism on gastrointestinal cancer, neurogenic cancer and other cancers (breast cancer and SCCHN). All the analyses were carried out in STATA 14.1.11 case\u2013control studies that consisted of 5730 cases and 6756 controls, were eventually included in our meta-analysis. The significant association was observed between the XPFrs2276466 polymorphism and neurogenic cancer susceptibility (recessive model: OR = 1.648, 95% CI = 1.294\u20132.098, P&amp;lt;0.001). Furthermore, no significant impact of this polymorphism was detected on decreased gastrointestinal cancer risk (dominant model: OR = 1.064, 95%CI = 0.961\u20131.177, P = 0.233). The rs2276466 polymorphism might play different roles in carcinogenesis of various cancer types. Current evidence did not suggest that this polymorphism was directly associated with gastrointestinal susceptibility. However, this polymorphism might contribute to increased neurogenic cancer risk. More preclinical and epidemiological studies are still imperative for further evaluation<\/jats:p>","DOI":"10.1042\/bsr20181785","type":"journal-article","created":{"date-parts":[[2019,4,30]],"date-time":"2019-04-30T16:16:01Z","timestamp":1556640961000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Impact of XPF rs2276466 polymorphism on cancer susceptibility: a meta-analysis"],"prefix":"10.1042","volume":"39","author":[{"given":"Yezhou","family":"Liu","sequence":"first","affiliation":[{"name":"Academy of Basic Medicine, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Joint and Trauma Orthopedics, Bayingolin People\u2019s Hospital, Korla, Xinjiang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xueru","family":"Zhao","sequence":"additional","affiliation":[{"name":"Academy of Basic Medicine, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yidan","family":"Sun","sequence":"additional","affiliation":[{"name":"Academy of Basic Medicine, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Longmei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Haitao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xia","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lina","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meina","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Social Medicine and Health Care Management, School of Public Health, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bingshuang","family":"Wang","sequence":"additional","affiliation":[{"name":"Academy of Basic Medicine, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6644-0469","authenticated-orcid":false,"given":"Xiaolin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Statistics, School of Public Health, Hebei Medical University, Hebei Province Key Laboratory of Environment and Human Health, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jinhai","family":"Jia","sequence":"additional","affiliation":[{"name":"Outpatient Clinics, Hebei Medical University, Shi Jiazhuang, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2019,5,24]]},"reference":[{"key":"2021111619333165700_B1","doi-asserted-by":"publisher","first-page":"9357","DOI":"10.1007\/s13277-016-4815-6","article-title":"Influence of XPC, XPD, XPF, and XPG gene polymorphisms on the risk and the outcome of acute myeloid leukemia in a Romanian population","volume":"37","author":"Banescu","year":"2016","journal-title":"Tumour Biol."},{"key":"2021111619333165700_B2","doi-asserted-by":"publisher","first-page":"4990","DOI":"10.1038\/s41598-017-04150-5","article-title":"CD31hiEmcnhi vessels support new trabecular bone formation at the frontier growth area in the bone defect repair process","volume":"7","author":"Wang","year":"2017","journal-title":"Sci. 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