{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T06:25:40Z","timestamp":1785911140859,"version":"3.56.0"},"reference-count":34,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2019,7,26]],"date-time":"2019-07-26T00:00:00Z","timestamp":1564099200000},"content-version":"vor","delay-in-days":220,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2018,12,21]]},"abstract":"<jats:p>Nephrotoxicity is a major toxic effect in chemotherapy, which constitutes up to 60% of hospitalized acute kidney injury (AKI). Very few treatment options exist to slow the transition from AKI to subsequent chronic kidney diseases (CKD). Here, we demonstrate that galectin-3 (Gal-3), a \u03b2-galactoside binding lectin that plays an important role in kidney fibrosis and renal failure, is one of the key factors for renal injury progression. Ectopic overexpression of Gal-3 significantly decreased the viability of HEK293, simultaneously inducing of cell cycle arrest and apoptosis. However, inhibition of Gal-3, mediated by modified citrus pectin (MCP), predominantly antagonized the pro-apoptotic effects. Mice were pre-treated with normal or 1% MCP-supplemented drinking water 1 week before cisplatin injection. Analyses of serum creatinine and renal tissue damage indicated that MCP-treated mice demonstrated increased renal function and attenuated renal fibrosis after cisplatin-induced injury. MCP-treated mice also demonstrated decreased renal fibrosis and apoptosis, as revealed by masson trichrome staining and Western blot analysis of cleaved caspase-3. Additionally, the protective role of Gal-3 inhibition in the kidney injury was shown to be mediated by protein kinase C \u03b1 (PKC-\u03b1), which promoted cell apoptosis and collagen I synthesis in HEK293 cells. These results demonstrated the potential Gal-3 and PKC-\u03b1 as therapeutic targets for the treatment of AKI and CKD.<\/jats:p>","DOI":"10.1042\/bsr20181803","type":"journal-article","created":{"date-parts":[[2018,11,19]],"date-time":"2018-11-19T16:21:52Z","timestamp":1542644512000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":37,"title":["Galectin 3 inhibition attenuates renal injury progression in cisplatin-induced nephrotoxicity"],"prefix":"10.1042","volume":"38","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3307-4028","authenticated-orcid":false,"given":"Hong-yan","family":"Li","sequence":"first","affiliation":[{"name":"Division of Nephrology, Huadu District People\u2019s Hospital of Guangzhou, Southern Medical University, Guangzhou 510800, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shen","family":"Yang","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Huadu District People\u2019s Hospital of Guangzhou, Southern Medical University, Guangzhou 510800, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-chun","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Huadu District People\u2019s Hospital of Guangzhou, Southern Medical University, Guangzhou 510800, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-xun","family":"Feng","sequence":"additional","affiliation":[{"name":"Division of Nephrology, Xuhui District Centeral Hospital of Shanghai, Shanghai, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2018,12,18]]},"reference":[{"key":"2021111619232497900_B1","doi-asserted-by":"publisher","first-page":"293","DOI":"10.1146\/annurev-med-050214-013407","article-title":"Acute kidney injury","volume":"67","author":"Zuk","year":"2016","journal-title":"Annu. Rev. Med."},{"key":"2021111619232497900_B2","doi-asserted-by":"publisher","first-page":"46","DOI":"10.1038\/ki.2014.293","article-title":"The growth of acute kidney injury: a rising tide or just closer attention to detail?","volume":"87","author":"Siew","year":"2015","journal-title":"Kidney Int."},{"key":"2021111619232497900_B3","first-page":"1","article-title":"Kidney disease: improving global outcomes (KDIGO) acute kidney injury work group. KDIGO clinical practice guideline for acute kidney injury","volume":"2","author":"Kellum","year":"2012","journal-title":"Kidney Int. 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