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In the present work, SGD was orally administrated to the PCOS rats at the dose of 12.5, 25, and 50 g\/kg\/d for 14 consecutive days. UPLC\u2013MS\/MS was performed to identify the main chemical components of SGD. Body weight, ovarian weight, cystic dilating follicles, and serum levels of steroid hormones were tested to evaluate the therapeutic effect of SGD. In order to further clarify the underlying mechanism, we also measured mRNA and the protein levels of NF-\u03baB, NF-\u03baB p65, P-NF-\u03baB p65, and I\u03baB by RT-qPCR and Western blotting techniques. Our results showed that SGD treatment significantly alleviated hyperandrogenism in PCOS rats as evidenced by reduced serum levels of T and increased E2 and FSH levels. In addition, SGD effectively reduced the phosphorylation of NF-\u03baB p65 and increased the expression of I\u03baB. Results of the present study demonstrated that SGD could ameliorate hyperandrogenism in PCOS rats, and the potential mechanism may relate to the NF-\u03baB pathway.<\/jats:p>","DOI":"10.1042\/bsr20181877","type":"journal-article","created":{"date-parts":[[2018,12,20]],"date-time":"2018-12-20T16:55:18Z","timestamp":1545324918000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Shaoyao-Gancao Decoction alleviated hyperandrogenism in a letrozole-induced rat model of polycystic ovary syndrome by inhibition of NF-\u03baB activation"],"prefix":"10.1042","volume":"39","author":[{"given":"Yun-yun","family":"Shao","sequence":"first","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhuang-peng","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin-chun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing-ping","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-juan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi-ting","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun-jin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui-gang","family":"Hou","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, Second Hospital of Shanxi Medical University, Shanxi 030000, China"},{"name":"School of Pharmaceutical, Shanxi Medical University, Shanxi 030000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,1,11]]},"reference":[{"key":"2021111617052903300_B1","doi-asserted-by":"publisher","first-page":"10","DOI":"10.1155\/2014\/670743","article-title":"Cryptotanshinone reverses reproductive and metabolic disturbances in PCOS model rats via regulating the expression of CYP17 and AR","volume":"2014","author":"Yu","year":"2014","journal-title":"J. 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