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In recent studies, RAS has also been implicated in the development of obesity, diabetes, hyperlipidemia, and other diseases, and also involved in the regulation of several signaling pathways such as proliferation, apoptosis and autophagy, and insulin resistance. AMP-activated protein kinase (AMPK), an essential cellular energy sensor, has also been discovered to be involved in these diseases and cellular pathways. This would imply a connection between the RAS and AMPK. Therefore, this review serves to draw attention to the cross-talk between RAS and AMPK, then summering the most recent literature which highlights AMPK as a point of balance between physiological and pathological functions of the RAS.<\/jats:p>","DOI":"10.1042\/bsr20181994","type":"journal-article","created":{"date-parts":[[2019,8,14]],"date-time":"2019-08-14T16:35:12Z","timestamp":1565800512000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":60,"title":["AMPK: a balancer of the renin\u2013angiotensin system"],"prefix":"10.1042","volume":"39","author":[{"given":"Jia","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, China"},{"name":"Department of Surgery, University of South Florida, Tampa, FL 33612, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuan","family":"Li","sequence":"additional","affiliation":[{"name":"Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qingguo","family":"Lu","sequence":"additional","affiliation":[{"name":"Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Di","family":"Ren","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of South Florida, Tampa, FL 33612, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaodong","family":"Sun","sequence":"additional","affiliation":[{"name":"Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"Rousselle","sequence":"additional","affiliation":[{"name":"Mississippi Center for Heart Research, Department of Physiology and Biophysics, University of Mississippi Medical Center, Jackson, MS 39216, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0899-4412","authenticated-orcid":false,"given":"Ji","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Surgery, University of South Florida, Tampa, FL 33612, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8525-0735","authenticated-orcid":false,"given":"Jiyan","family":"Leng","sequence":"additional","affiliation":[{"name":"Department of Geriatrics, The First Hospital of Jilin University, Changchun 130021, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,9,3]]},"reference":[{"key":"2021111619485115900_B1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1016\/j.phrs.2017.06.005","article-title":"The vasoprotective axes of the renin-angiotensin system: Physiological relevance and therapeutic implications in cardiovascular, hypertensive and kidney diseases","volume":"125","author":"Li","year":"2017","journal-title":"Pharmacol. 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