{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T12:30:08Z","timestamp":1784896208307,"version":"3.55.0"},"reference-count":50,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":141,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objective: In this work, the relationship between octamer binding transcription factor 4 (OCT-4) expression and the clinicopathological features of cervical cancer (CC) is evaluated in detail.<\/jats:p>\n               <jats:p>Methods: The library databases Pubmed, Embase, Cochrane library, Wan Fang and Chinese National Knowledge Infrastructure (CNKI) were searched for research related to these concepts published from the time the databases were established until May 2018. The obtained studies are screened, extracted, and evaluated according to the inclusion and exclusion criteria, and meta-analysis is carried out via RevMan 5.3.<\/jats:p>\n               <jats:p>Results: Ten case\u2013control studies, including 408 cases of CC, 164 cases of cervical intraepithelial neoplasia (CIN), and 148 cases of normal cervix, are included in the analysis. Results show that OCT-4 levels are statistically significantly different between the CC and normal cervical tissue groups (odds ratio (OR) = 15.59, 95% confidence interval (CI): 8.70, 27.94), the CC and CIN groups (OR = 5.64, 95% CI: 3.23, 9.86), the CIN and normal cervical tissues groups (OR = 7.13, 95% CI: 2.41, 21.05), and the CC well\/moderately differentiated and poorly differentiated groups (OR = 0.44, 95% CI: 0.24, 0.81). OCT-4 is not statistically significantly different between CIN I + II and CIN III tissues (OR = 0.40, 95% CI: \u22120.02, 0.81), the CC lymphatic and non-lymphatic metastasis groups (OR = 1.93, 95% CI: 0.83, 4.47), the FIGO I and FIGO II groups (OR = 0.79, 95% CI: 0.29, 2.13), and the adenocarcinoma and squamous cell carcinoma groups (OR = 1.55, 95% CI: 0.70, 3.44).<\/jats:p>\n               <jats:p>Conclusions: The available evidence suggests that OCT-4 expression is associated with CC malignancy and histological differentiation. This finding, however, is subject to quantitative studies and quality tests.<\/jats:p>","DOI":"10.1042\/bsr20182328","type":"journal-article","created":{"date-parts":[[2019,4,12]],"date-time":"2019-04-12T18:15:12Z","timestamp":1555092912000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Octamer binding transcription factor-4 expression is associated with cervical cancer malignancy and histological differentiation: a systematic review and meta-analysis"],"prefix":"10.1042","volume":"39","author":[{"given":"Zi-ye","family":"Gao","sequence":"first","affiliation":[{"name":"Department of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao-bo","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng-mei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ling","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Neonatology, Northwest Women and Children Hospital, Xi\u2019an 710000, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin-zhang","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Pediatric medicine, Northwest Women and Children Hospital, Xi\u2019an 710000, Shanxi, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6616-9736","authenticated-orcid":false,"given":"Sheng-bao","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Oncology, Taihe Hospital, Hubei University of Medicine, Shiyan 442000, Hubei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"2021111619371662700_B1","first-page":"402","article-title":"Detection of cervical cancer through visual inspection of cervix with acetic acid (VIA) and colposcopy at Mymensingh Medical College Hospital","volume":"25","author":"Rahman","year":"2016","journal-title":"Mymensingh Med. 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