{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T12:14:47Z","timestamp":1790338487980,"version":"4.1.0"},"reference-count":19,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":110,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,6,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Gut microbiota plays an important role in the regulation of the immune system and host\u2019s metabolism. We aimed to characterize the gut microbiota of Tunisian participants with and without diabetes.<\/jats:p>\n               <jats:p>We enrolled ten participants with type 1 diabetes mellitus (T1DM), ten patients with type 2 diabetes mellitus (T2DM), and 11 subjects without diabetes. Bacteria was quantified in fecal samples by quantitative PCR (qPCR). Statistical tests and multivariate analysis were performed using RStudio program.<\/jats:p>\n               <jats:p>Results showed that the proportions of Firmicutes, Akkermansia muciniphila, and Faecalibacterium prausnitzii (P\u22640.041), as well as, the ratio Firmicutes\/Bacteroidetes decreased in participants with T1DM compared with those without diabetes (p = 0.036). Participants with T2DM presented a reduction in the amounts of A. muciniphila and F. prausnitzii compared with those without diabetes (P\u22640.036). Furthermore, A muciniphila is negatively correlated with glucose level (P=0.022) and glycated hemoglobin (HbA1c) (P=0.035). Multivariate analysis revealed that participants with diabetes formed a cluster apart compared with those without diabetes.<\/jats:p>\n               <jats:p>In conclusion the gut bacteria of Tunisian participants with diabetes was altered. The gut bacterial profile, especially the distribution of A muciniphila in participants with diabetes was affected by glycemic dysregulation. The investigation of the gut microbiota may help clinicians to improve diagnosis and treatment of diabetes and its complications.<\/jats:p>","DOI":"10.1042\/bsr20182348","type":"journal-article","created":{"date-parts":[[2019,5,30]],"date-time":"2019-05-30T18:45:18Z","timestamp":1559241918000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":62,"title":["Gut microbiota imbalances in Tunisian participants with type 1 and type 2 diabetes mellitus"],"prefix":"10.1042","volume":"39","author":[{"given":"Meriem","family":"Fassatoui","sequence":"first","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, 13, Place Pasteur, B.P.74, 1002, Belv\u00e9d\u00e8re, Tunis, Tunisia"},{"name":"University of Tunis El Manar, Campus Universitaire Farhat Hached, BP n\u00b0 94, Rommana, 1068, Tunis, Tunisia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireia","family":"Lopez-Siles","sequence":"additional","affiliation":[{"name":"Laboratory of Molecular Microbiology, Biology Department, Universitat de Girona, Maria Aur\u00e8lia Capmany, 40, 17003, Girona, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana\u00a0A.","family":"D\u00edaz-Rizzolo","sequence":"additional","affiliation":[{"name":"Diabetes and Obesity Research Laboratory, Institut d\u2019Investigations Biom\u00e8diques, August Pi I Sunyer (IDIBAPS), Hospital Clinic, Rossell\u00f3 149-153, 08036, Barcelona Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifa","family":"Jmel","sequence":"additional","affiliation":[{"name":"Laboratory of Biomedical Genomics and Oncogenetics, Institut Pasteur de Tunis, 13, Place Pasteur, B.P.74, 1002, Belv\u00e9d\u00e8re, Tunis, 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