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Sirtuin 1 (SIRT 1), a longevity gene related to many diseases associated with aging, is a nicotinamide adenine dinucleotide (NAD+)-dependent protein deacetylase and master metabolic regulator. Along with its natural activator resveratrol, SIRT 1 actively participates in the OA pathological progress. SIRT 1 expression in osteoarthritic cartilage decreases in the disease progression of OA; it appears to play a predominantly regulatory role in OA. SIRT 1 can regulate the expression of extracellular matrix (ECM)-related proteins; promote mesenchymal stem cell differentiation; play anti-catabolic, anti-inflammatory, anti-oxidative stress, and anti-apoptosis roles; participate in the autophagic process; and regulate bone homeostasis in OA. Resveratrol can activate SIRT 1 in order to inhibit OA disease progression. In the future, activating SIRT 1 via resveratrol with improved bioavailability may be an appropriate therapeutic approach for OA.<\/jats:p>","DOI":"10.1042\/bsr20190189","type":"journal-article","created":{"date-parts":[[2019,4,17]],"date-time":"2019-04-17T16:10:13Z","timestamp":1555517413000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["The role of sirtuin 1 and its activator, resveratrol in osteoarthritis"],"prefix":"10.1042","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0522-8269","authenticated-orcid":false,"given":"Zhenhan","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"Department of Sports Medicine, The First Hospital Affiliated of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yusheng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haifeng","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Sports Medicine, The First Hospital Affiliated of Shenzhen University, Shenzhen Second People\u2019s Hospital, Shenzhen, Guangdong, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengshi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, Zhuzhou Central Hospital, Zhuzhou, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangjun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Joint Surgery, Changsha Central Hospital, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Tian","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Cheng","sequence":"additional","affiliation":[{"name":"Department of Orthopaedics, Yiyang Central Hospital, Clinical Medical Technology Demonstration Base for Minimally Invasive and Digital Orthopaedics in Hunan Province, Yiyang, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Zhang","sequence":"additional","affiliation":[{"name":"McGovern Medical School, University of Texas Health Science Center at Houston, Houston, Texas, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangjie","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Emergency Medicine, Xiangya Hospital, Central South University, Changsha, Hunan, China"},{"name":"National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,5,10]]},"reference":[{"key":"2021111619351626500_B1","doi-asserted-by":"publisher","first-page":"e4934","DOI":"10.1136\/bmj.e4934","article-title":"Management of osteoarthritis of the knee","volume":"345","author":"Bennell","year":"2012","journal-title":"BMJ"},{"key":"2021111619351626500_B2","doi-asserted-by":"publisher","first-page":"312","DOI":"10.1016\/j.berh.2018.10.007","article-title":"Update on the epidemiology, risk factors and disease outcomes of osteoarthritis","volume":"32","author":"O\u2019Neill","year":"2018","journal-title":"Best Pract. 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