{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:34:30Z","timestamp":1787067270023,"version":"build-2736575974"},"reference-count":12,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":12,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Aim: To investigate the relationship between PI3K\/Akt\/NF-\u03baB cellular signal pathway and the expression of P-gp and LRP in multidrug resistance (MDR) cell of nasopharyngeal carcinoma.<\/jats:p>\n                  <jats:p>Method: The PI3K, p-Akt and NF-\u03baB\/p65 as the activity of PI3K\/Akt\/NF-\u03baB were detected by Western blot. The expressions of LRP and P-gp were detected by Western blot and real-time PCR.<\/jats:p>\n                  <jats:p>Result: The RIs of CNE\/DDP group to DDP, 5-Fu, VCR, ADR and PTX were 35.04, 18.14, 24.13, 12.00 and 10.18, respectively. The RIs of LY-294002 group were 11.77, 5.83, 3.07, 3.86 and 3.34, and PDTC group were 11.08, 6.55, 7.66, 2.18 and 4.05. The expressions of PI3K, p-Akt and NF-\u03baBp65, LRP and P-gp were increased and mRNA of LRP and P-gp were up-regulated in CNE\/DDP. The expression of p-Akt in LY-294002 group was down-regulated. The expression of NF-\u03baB p65 in PDTC group was decreased. The mRNA of LRP and P-gp in LY-294002 group and PDTC group were decreased.<\/jats:p>\n                  <jats:p>Conclusion: MDR of nasopharyngeal carcinoma cell can be regulated by activating PI3K\/Akt\/NF-\u03baB signal pathway and then increase the expression of P-gp and LRP. The MDR of nasopharyngeal carcinoma cell can be reversed by inhibiting PI3K\/Akt\/NF-\u03baB signal pathway.<\/jats:p>","DOI":"10.1042\/bsr20190239","type":"journal-article","created":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T15:40:57Z","timestamp":1589384457000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["The multidrug resistance can be reversed for the decrease of P-gp and LRP by inhibiting PI3K\/Akt\/NF-\u03baB signal pathway in nasopharynx carcinoma"],"prefix":"10.1042","volume":"40","author":[{"given":"Jin","family":"Liu","sequence":"first","affiliation":[{"name":"Post-Doctoral Station of Combination of Chinese Traditional and Western Medicine, Hunan University of Chinese Medicine, Changsha, Hunan 410208, China"},{"name":"Department of Otolaryngology Head and Neck Surgery, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyi","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of Pathophysiology, Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yun","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Neurology, Affiliated Hospital of Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4248-1423","authenticated-orcid":false,"given":"Qianli","family":"Tang","sequence":"additional","affiliation":[{"name":"Hunan University of Chinese Medicine, Changsha, Hunan 410208, China"},{"name":"Youjiang Medical University for Nationalities, Baise, Guangxi 533000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meng","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Oncology, First Affiliated Hospital of Jinan University, Guangzhou, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,5,27]]},"reference":[{"key":"2021111620115284400_B1","doi-asserted-by":"publisher","first-page":"2223","DOI":"10.3892\/mmr.2017.6233","article-title":"microRNA-125b reverses the multidrug resistance of nasopharyngeal carcinoma cells via targeting of Bcl-2","volume":"15","author":"Yuan","year":"2017","journal-title":"Mol. 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