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CMS currently affects more than 25% of the world\u2019s population and the rates of diseases are rapidly rising. These CMS conditions represent critical risk factors for cardiovascular diseases including atherosclerosis, heart failure, myocardial infarction, and peripheral artery disease (PAD). Therefore, it is imperative to elucidate the underlying signaling involved in disease onset and progression. The c-Jun N-terminal Kinases (JNKs) are a family of stress signaling kinases that have been recently indicated in CMS. The purpose of this review is to examine the in vivo implications of JNK as a potential therapeutic target for CMS. As the constellation of diseases associated with CMS are complex and involve multiple tissues and environmental triggers, carefully examining what is known about the JNK pathway will be important for specificity in treatment strategies.<\/jats:p>","DOI":"10.1042\/bsr20190267","type":"journal-article","created":{"date-parts":[[2019,7,3]],"date-time":"2019-07-03T15:49:01Z","timestamp":1562168941000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["JNK and cardiometabolic dysfunction"],"prefix":"10.1042","volume":"39","author":[{"given":"Siobhan\u00a0M.","family":"Craige","sequence":"first","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A."},{"name":"Department of Human Nutrition, Foods, and Exercise, Virginia Tech, VA 24061, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Medicine, University of Connecticut Health Center, Farmington, CT 06030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert\u00a0M.","family":"Blanton","sequence":"additional","affiliation":[{"name":"Molecular Cardiology Research Institute, Tufts Medical Center, Boston, MA 02111, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"Jr","given":"John\u00a0F.","family":"Keaney","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8772-6813","authenticated-orcid":false,"given":"Shashi","family":"Kant","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Medicine, Department of Medicine, University of Massachusetts Medical School, Worcester, MA 01605, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"2021111619415362500_B1","doi-asserted-by":"publisher","first-page":"155","DOI":"10.4103\/0253-7613.93579","article-title":"Challenges in the treatment of cardiometabolic syndrome","volume":"44","author":"Srivastava","year":"2012","journal-title":"Indian J. 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