{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T09:48:53Z","timestamp":1790156933384,"version":"4.0.1"},"reference-count":58,"publisher":"Portland Press Ltd.","issue":"7","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":80,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,7,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objective: To investigate whether microRNAs genes\u2019 polymorphisms are associated with arthritis. Methods: The PubMed, Cochrane Library et al. were systematically searched to identify case\u2013control studies, systematic reviews and meta-analyses. A meta-analysis was performed to calculate odds ratios (ORs), and confidence intervals (CIs) at 95% using fixed-effect model or random-effects model. Results: Twenty-two case\u2013control studies involving 10489 participants fulfilled the inclusion criteria. MiR-146a rs2910164 (G\/C) was not significantly associated with the risk of rheumatoid arthritis (RA) in any model. Significant associations were found between miR-146a rs2910164 (G\/C) and the risk of psoriatic arthritis (PsA) in the heterozygous model and the dominant model. The heterozygous model showed a significant association between the miR-146a rs2910164 (G\/C) polymorphism and ankylosing spondylitis (AS). And there was no significant association of miR-146a rs2910164 (G\/C) with risk of juvenile rheumatoid arthritis (JRA) at any model. Additionally, there was a significant association of miR-499 rs3746444 (T\/C) with risk of RA at two genetic models, and with a moderate heterogeneity. When subgroup analysis by ethnicity, significant associations were almost found between miR-499 rs3746444 (T\/C) and the risk of RA in any model in Caucasian populations, and there is no heterogeneity. Conclusions: The association of miR-146a rs2910164 (G\/C) with RA was not found. And there was a significant association between miR-146a rs2910164(G\/C) and PsA or AS. MiR-499 rs3746444 (T\/C) was associated with RA in Caucasian populations. These findings did not support the genetic association between miR-146a rs2910164 (G\/C) and JRA susceptibility, as well as the association of miR-196a-2 rs11614913 (C\/T), miR-146a rs2431697, miR-146a rs57095329, miR-149 rs22928323 with arthritis.<\/jats:p>","DOI":"10.1042\/bsr20190298","type":"journal-article","created":{"date-parts":[[2019,6,24]],"date-time":"2019-06-24T22:19:48Z","timestamp":1561414788000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Association of microRNAs genes polymorphisms with arthritis: a systematic review and meta-analysis"],"prefix":"10.1042","volume":"39","author":[{"given":"Yingqi","family":"Xiao","sequence":"first","affiliation":[{"name":"West China School of Nursing\/West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Liu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Birth Deficits and Related Diseases of Women and Children, West China Second Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Department, Childrens Hospital of Chongqing Medical University, Chongqing 401147, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Radiology, The Xiangan Hospital of Xia Men University, Xiamen 361101, Fujian Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaolian","family":"Jiang","sequence":"additional","affiliation":[{"name":"West China School of Nursing\/West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,7,19]]},"reference":[{"key":"2021111619430510100_B1","article-title":"Mesh: Arthritis[DB\/OL]. 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