{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:07:59Z","timestamp":1787004479939,"version":"build-2736575974"},"reference-count":53,"publisher":"Portland Press Ltd.","issue":"12","license":[{"start":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T00:00:00Z","timestamp":1574985600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Background: Prostaglandin-E1 (PGE1) is a potent vasodilator with anti-inflammatory and antiplatelet effects. However, the mechanism by which PGE1 contributes to the amelioration of cardiac injury remains unclear.<\/jats:p>\n                  <jats:p>Methods: The present study was designed to investigate how PGE1 protects against hypoxia\/reoxygenation (H\/R)-induced injuries by regulating microRNA-21-5p (miR-21-5p) and fas ligand (FASLG). Rat H9C2 cells and isolated primary cardiomyocytes were cultured under hypoxic conditions for 6 h (6H, hypoxia for 6 h), and reoxygenated for periods of 6 (6R, reoxygenation for 6 h), 12, and 24 h, respectively. Cells from the 6H\/6R group were treated with various doses of PGE1; after which, their levels of viability and apoptosis were detected.<\/jats:p>\n                  <jats:p>Results: The 6H\/6R treatment regimen induced the maximum level of H9C2 cell apoptosis, which was accompanied by the highest levels of Bcl-2-associated X protein (Bax) and cleaved-caspase-3 expression and the lowest level of B-cell lymphoma 2 (Bcl-2) expression. Treatment with PGE1 significantly diminished the cell cytotoxicity and apoptosis induced by the 6H\/6R regimen, and also decreased expression of IL-2, IL-6, P-p65, TNF-\u03b1, and cleaved-caspase-3. In addition, we proved that PGE1 up-regulated miR-21-5p expression in rat cardiomyocytes exposed to conditions that produce H\/R injury. FASLG was a direct target of miR-21-5p, and PGE1 reduced the ability of H\/R-injured rat cardiomyocytes to undergo apoptosis by affecting the miR-21-5p\/FASLG axis. In addition, we proved that PGE1 could protect primary cardiomyocytes against H\/R-induced injuries.<\/jats:p>\n                  <jats:p>Conclusions: These results indicate that PGE1 exerts cardioprotective effects in H9C2 cells during H\/R by regulating the miR-21-5p\/FASLG axis.<\/jats:p>","DOI":"10.1042\/bsr20190597","type":"journal-article","created":{"date-parts":[[2019,11,29]],"date-time":"2019-11-29T06:22:03Z","timestamp":1575008523000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Prostaglandin E1 protects cardiomyocytes against hypoxia-reperfusion induced injury via the miR-21-5p\/FASLG axis"],"prefix":"10.1042","volume":"39","author":[{"given":"Mingxiang","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-678X","authenticated-orcid":false,"given":"Hongwei","family":"Pan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaofen","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianqiang","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yangping","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin","family":"He","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sulan","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Hunan Provincial People\u2019s Hospital & First Affiliated Hospital of Hunan Normal University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yulu","family":"Zhou","sequence":"additional","affiliation":[{"name":"Depatment of Pharmacy, The third Xiangya Hospital of Central South University, Changsha, Hunan, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,12,16]]},"reference":[{"key":"2021111619560772500_B1","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1161\/01.RES.80.3.336","article-title":"Hypoxia\/reoxygenation stimulates Jun kinase activity through redox signaling in cardiac myocytes","volume":"80","author":"Laderoute","year":"1997","journal-title":"Circ. 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