{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T08:45:00Z","timestamp":1769244300083,"version":"3.49.0"},"reference-count":19,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":141,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,5,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>The dysregulated expression of LSINCT5 (long stress-induced non-coding transcript 5) has been found in various human tumors, and was generally related to cancer progression and unfavorable prognosis. Although the role of LSINCT5 in osteosarcoma was reported not long ago, the sample size of that study was limited. Our study presented more evidence about the clinical significance and biological function of LSINCT5 in osteosarcoma. In our results, we found LSINCT5 expression was increased in osteosarcoma tissue samples and cell lines, and high LSINCT5 expression was associated with advanced Enneking stage, large tumor size, high histological grade and present distant metastasis. Meanwhile, we observed high LSINCT5 expression was correlated with worse overall survival, and high LSINCT5 expression could be an independent poor predictor for overall survival in osteosarcoma cases. Moreover, we found inhibition of LSINCT5 expression suppressed cell proliferation, migration and invasion in vitro, and LSINCT5 overexpression dramatically facilitated cell proliferation, migration and invasion in vitro. In conclusion, our study suggests that LSINCT5 exerts oncogenic function in osteosarcoma cells, and may be a potential predictor for clinical outcome in osteosarcoma patients.<\/jats:p>","DOI":"10.1042\/bsr20190612","type":"journal-article","created":{"date-parts":[[2019,4,9]],"date-time":"2019-04-09T17:20:19Z","timestamp":1554830419000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["LSINCT5 predicts unfavorable prognosis and exerts oncogenic function in osteosarcoma"],"prefix":"10.1042","volume":"39","author":[{"given":"Weidong","family":"He","sequence":"first","affiliation":[{"name":"Department of Joint Surgery, The First People\u2019s Hospital of Lianyungang, Lianyungang 222002, Jiangsu, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Medical School of Chinese PLA, Beijing 100853, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3002-6191","authenticated-orcid":false,"given":"Dongbo","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Ankang Central Hospital, Ankang 725000, Shaanxi, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2019,5,3]]},"reference":[{"key":"2021111619375921600_B1","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1186\/s13028-017-0341-9","article-title":"Comparative review of human and canine osteosarcoma: morphology, epidemiology, prognosis, treatment and genetics","volume":"59","author":"Simpson","year":"2017","journal-title":"Acta Vet. Scand."},{"key":"2021111619375921600_B2","first-page":"690","article-title":"Multidisciplinary approach to osteosarcoma","volume":"82","author":"Biazzo","year":"2016","journal-title":"Acta Orthop. Belg."},{"key":"2021111619375921600_B3","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1007\/s11912-018-0658-1","article-title":"Primary osteosarcoma in the elderly revisited: current concepts in diagnosis and treatment","volume":"20","author":"Kumar","year":"2018","journal-title":"Curr. Oncol. Rep."},{"key":"2021111619375921600_B4","doi-asserted-by":"publisher","first-page":"36","DOI":"10.1016\/j.jbo.2017.11.005","article-title":"Advances in limb salvage treatment of osteosarcoma","volume":"10","author":"Yang","year":"2018","journal-title":"J. Bone Oncol."},{"key":"2021111619375921600_B5","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1080\/14737140.2018.1413939","article-title":"Current and future therapeutic approaches for osteosarcoma","volume":"18","author":"Harrison","year":"2018","journal-title":"Expert Rev. Anticancer Ther."},{"key":"2021111619375921600_B6","doi-asserted-by":"publisher","first-page":"pii:E7","DOI":"10.3390\/ncrna4010007","article-title":"The role of long non-coding RNAs in osteosarcoma","volume":"4","author":"Smolle","year":"2018","journal-title":"Noncoding RNA"},{"key":"2021111619375921600_B7","doi-asserted-by":"crossref","first-page":"20462","DOI":"10.18632\/oncotarget.14726","article-title":"Long non-coding RNAs in osteosarcoma","volume":"8","author":"Chen","year":"2017","journal-title":"Oncotarget"},{"key":"2021111619375921600_B8","doi-asserted-by":"publisher","first-page":"6761","DOI":"10.3892\/mmr.2015.4247","article-title":"Increased B-type-natriuretic peptide promotes myocardial cell apoptosis via the B-type-natriuretic peptide\/long non-coding RNA LSINCT5\/caspase-1\/interleukin 1beta signaling pathway","volume":"12","author":"Zhang","year":"2015","journal-title":"Mol. Med. Rep."},{"key":"2021111619375921600_B9","doi-asserted-by":"publisher","first-page":"1097","DOI":"10.1016\/j.bbagrm.2014.08.012","article-title":"LncRNA: a link between RNA and cancer","volume":"1839","author":"Yang","year":"2014","journal-title":"Biochim. Biophys. Acta"},{"key":"2021111619375921600_B10","doi-asserted-by":"publisher","first-page":"193","DOI":"10.1016\/j.bbrc.2018.11.005","article-title":"Long noncoding RNA LSINCT5 acts as an oncogene via increasing EZH2-induced inhibition of APC expression in osteosarcoma","volume":"507","author":"Kong","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111619375921600_B11","doi-asserted-by":"publisher","first-page":"355","DOI":"10.1016\/j.ygeno.2010.02.009","article-title":"Identification of long stress-induced non-coding transcripts that have altered expression in cancer","volume":"95","author":"Silva","year":"2010","journal-title":"Genomics"},{"key":"2021111619375921600_B12","doi-asserted-by":"publisher","first-page":"496","DOI":"10.4161\/rna.8.3.14800","article-title":"LSINCT5 is over expressed in breast and ovarian cancer and affects cellular proliferation","volume":"8","author":"Silva","year":"2011","journal-title":"RNA Biol."},{"key":"2021111619375921600_B13","doi-asserted-by":"publisher","first-page":"1188","DOI":"10.1080\/15384101.2018.1467675","article-title":"The long non-coding RNA LSINCT5 promotes malignancy in non-small cell lung cancer by stabilizing HMGA2","volume":"17","author":"Tian","year":"2018","journal-title":"Cell Cycle"},{"key":"2021111619375921600_B14","doi-asserted-by":"publisher","first-page":"8510","DOI":"10.12659\/MSM.911179","article-title":"Long Stress Induced Non-Coding Transcripts 5 (LSINCT5) promotes hepatocellular carcinoma progression through interaction with high-mobility group AT-hook 2 and MiR-4516","volume":"24","author":"Li","year":"2018","journal-title":"Med Sci. Monitor."},{"key":"2021111619375921600_B15","doi-asserted-by":"publisher","first-page":"299","DOI":"10.1016\/j.bbrc.2018.05.076","article-title":"LSINCT5 activates Wnt\/beta-catenin signaling by interacting with NCYM to promote bladder cancer progression","volume":"502","author":"Zhu","year":"2018","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"2021111619375921600_B16","doi-asserted-by":"publisher","first-page":"e303","DOI":"10.1097\/MD.0000000000000303","article-title":"Long non-coding RNA LSINCT5 predicts negative prognosis and exhibits oncogenic activity in gastric cancer","volume":"93","author":"Xu","year":"2014","journal-title":"Medicine (Baltimore)"},{"key":"2021111619375921600_B17","doi-asserted-by":"publisher","first-page":"2563","DOI":"10.2147\/CMAR.S171652","article-title":"E2F1 induces LSINCT5 transcriptional activity and promotes gastric cancer progression by affecting the epithelial-mesenchymal transition","volume":"10","author":"Qi","year":"2018","journal-title":"Cancer Manag. Res."},{"key":"2021111619375921600_B18","first-page":"7200","article-title":"Long non-coding RNA LSINCT5 promotes ovarian cancer cell proliferation, migration and invasion by disrupting the CXCL12\/CXCR4 signalling axis","volume":"15","author":"Long","year":"2018","journal-title":"Oncol. Lett."},{"key":"2021111619375921600_B19","doi-asserted-by":"publisher","first-page":"876","DOI":"10.1111\/tbj.13067","article-title":"Expression levels of breast cancer-related GAS5 and LSINCT5 lncRNAs in cancer-free breast tissue: molecular associations with age at menarche and obesity","volume":"24","author":"Mansoori","year":"2018","journal-title":"Breast J."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20190612\/848198\/bsr-2019-0612.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20190612\/848198\/bsr-2019-0612.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:26:16Z","timestamp":1637094376000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/39\/5\/BSR20190612\/219187\/LSINCT5-predicts-unfavorable-prognosis-and-exerts"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,5]]},"references-count":19,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2019,5,31]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20190612","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,5]]},"published":{"date-parts":[[2019,5]]},"article-number":"BSR20190612"}}