{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T02:06:43Z","timestamp":1785463603770,"version":"3.56.0"},"reference-count":46,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,12,18]],"date-time":"2019-12-18T00:00:00Z","timestamp":1576627200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>We performed a retrospective study aiming to study the relationship between the ratio of the exogenous luteinizing hormone to follicle stimulating hormone (LH\/FSH) administrated for controlled ovarian stimulation (COS) and the number and competence of the oocytes retrieved for in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI). Eight hundred sixty-eight consecutive infertile patients (mean age 34.54 \u00b1 4.01 years, mean anti-M\u00fcllerian hormone (AMH) 2.94 \u00b1 2.07 ng\/ml) treated with long agonist protocol and a mixed gonadotropin protocol (human menopausal gonadotropin in association with recombinant FSH (recFSH)) who performed IVF\/ICSI between January 2013 and February 2016, were included. Patients with severe male factor were excluded. LH\/FSH was calculated based on total doses of the two gonadotropins. We found, after adjustment for confounders, a positive relationship between LH\/FSH and the retrieved oocytes\u2019 (\u03b2 = 0.229, P&amp;lt;0.0001) and zygotes\u2019 number (\u03b2 = 0.144, P&amp;lt;0.0001) in the entire study group and in subgroups according to age (&amp;lt;35 and \u226535 years) and ovarian reserve (AMH &amp;lt; 1.1 and \u2265 1.1 ng\/ml). The fertilization rate was positively associated with LH\/FSH in patients with LH\/FSH in the lowest three quartiles (below 0.77) (\u03b2 = 0.096, P=0.034). However, patients in the fourth quartile of LH\/FSH had a lower fertilization rate as compared with patients in quartiles 1\u20133 which, after adjustment for covariates, was only marginally negatively related with LH\/FSH (\u03b2 = \u22120.108, P=0.05). In conclusion, our results suggest that the adequate LH\/FSH administrated during COS can improve the oocytes\u2019 and zygotes\u2019 number in IVF\/ICSI cycles, but also the fertilization rate when a certain proportion of LH\/FSH is not exceeded.<\/jats:p>","DOI":"10.1042\/bsr20190811","type":"journal-article","created":{"date-parts":[[2020,1,3]],"date-time":"2020-01-03T09:33:54Z","timestamp":1578044034000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["The ratio of exogenous Luteinizing hormone to Follicle stimulating hormone administered for controlled ovarian stimulation is associated with oocytes\u2019 number and competence"],"prefix":"10.1042","volume":"40","author":[{"given":"Dragos","family":"Albu","sequence":"first","affiliation":[{"name":"Carol Davila University of Medicine and Pharmacy, Faculty of Dentistry, Bucharest, Romania"},{"name":"Reproductive Medicine Department, Medlife Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5544-1212","authenticated-orcid":false,"given":"Alice","family":"Albu","sequence":"additional","affiliation":[{"name":"Reproductive Medicine Department, Medlife Hospital, Bucharest, Romania"},{"name":"Carol Davila University of Medicine and Pharmacy, 2nd Clinical Department, Bucharest, Romania"},{"name":"Endocrinology and Diabetes Department, Elias Hospital, Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,1,3]]},"reference":[{"key":"2021111619580042300_B1","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/09513590.2018.1540575","article-title":"Impact of infertility and infertility treatments on quality of life and levels of anxiety and depression in women undergoing in vitro fertilization","volume":"35","author":"Massarotti","year":"2019","journal-title":"Gynecol. 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