{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T17:18:03Z","timestamp":1779211083341,"version":"3.51.4"},"reference-count":152,"publisher":"Portland Press Ltd.","issue":"11","license":[{"start":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T00:00:00Z","timestamp":1572480000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Psoriasis is caused by a complex interplay among the immune system, genetic background, autoantigens, and environmental factors. Recent studies have demonstrated that patients with psoriasis have a significantly higher serum homocysteine (Hcy) level and a higher prevalence of hyperhomocysteinaemia (HHcy). Insufficiency of folic acid and vitamin B12 can be a cause of HHcy in psoriasis. Hcy may promote the immuno-inflammatory process in the pathogenesis of psoriasis by activating Th1 and Th17 cells and neutrophils, while suppressing regulatory T cells. Moreover, Hcy can drive the immuno-inflammatory process by enhancing the production of the pro-inflammatory cytokines in related to psoriasis. Hcy can induce nuclear factor kappa B activation, which is critical in the immunopathogenesis of psoriasis. There may be a link between the oxidative stress state in psoriasis and the effect of HHcy. Hydrogen sulfide (H2S) may play a protective role in the pathogenesis of psoriasis and the deficiency of H2S in psoriasis may be caused by HHcy. As the role of Hcy in the pathogenesis of psoriasis is most likely established, Hcy can be a potential therapeutic target for the treatment of psoriasis. Systemic folinate calcium, a folic acid derivative, and topical vitamin B12 have found to be effective in treating psoriasis.<\/jats:p>","DOI":"10.1042\/bsr20190867","type":"journal-article","created":{"date-parts":[[2019,10,31]],"date-time":"2019-10-31T12:22:39Z","timestamp":1572524559000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Homocysteine and psoriasis"],"prefix":"10.1042","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6860-4263","authenticated-orcid":false,"given":"Xiran","family":"Lin","sequence":"first","affiliation":[{"name":"Department of Dermatology, the First Affiliated Hospital of Dalian Medical University. 222 Zhongshan Lu, Dalian 116011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xianmin","family":"Meng","sequence":"additional","affiliation":[{"name":"Department of Pathology and laboratory medicine, Axia Women\u2019s Health. 450.Cresson BLVD. Oaks, PA 19456, U.S.A."}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhiqi","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Dermatology, the First Affiliated Hospital of Dalian Medical University. 222 Zhongshan Lu, Dalian 116011, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2019,11,22]]},"reference":[{"key":"2021111619540641500_B1","doi-asserted-by":"publisher","first-page":"496","DOI":"10.1056\/NEJMra0804595","article-title":"Psoriasis","volume":"361","author":"Nestle","year":"2009","journal-title":"N. Engl. J. Med."},{"key":"2021111619540641500_B2","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1016\/j.jaci.2017.07.004","article-title":"Psoriasis pathogenesis and the development of novel targeted immune therapies","volume":"140","author":"Hawkes","year":"2017","journal-title":"J. Allergy Clin. Immunol."},{"key":"2021111619540641500_B3","doi-asserted-by":"publisher","first-page":"345","DOI":"10.1016\/j.jaad.2018.02.040","article-title":"Interleukin 17, inflammation, and cardiovascular risk in patients with psoriasis","volume":"79","author":"Lockshin","year":"2018","journal-title":"J. Am. Acad. Dermatol."},{"key":"2021111619540641500_B4","doi-asserted-by":"publisher","first-page":"6","DOI":"10.1186\/1475-2891-14-6","article-title":"Role of homocysteine in the development of cardiovascular disease","volume":"14","author":"Ganguly","year":"2015","journal-title":"Nutr. J."},{"key":"2021111619540641500_B5","doi-asserted-by":"publisher","first-page":"E231","DOI":"10.3390\/ijms20010231","article-title":"The Controversial Role of Homocysteine in Neurology: From Labs to Clinical Practice","volume":"20","author":"Moretti","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B6","doi-asserted-by":"publisher","first-page":"78","DOI":"10.1186\/s12986-017-0233-z","article-title":"The metabolism and significance of homocysteine in nutrition and health","volume":"14","author":"Kumar","year":"2017","journal-title":"Nutr. Metab. (Lond)"},{"key":"2021111619540641500_B7","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1111\/bph.13988","article-title":"Hyperhomocysteinaemia and vascular injury: advances in mechanisms and drug targets","volume":"175","author":"Fu","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"2021111619540641500_B8","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1038\/clpt.1989.179","article-title":"Fasting plasma homocysteine as a sensitive parameter of antifolate effect: a study of psoriasis patients receiving low-dose methotrexate treatment","volume":"46","author":"Refsum","year":"1989","journal-title":"Clin. Pharmacol. Ther."},{"key":"2021111619540641500_B9","doi-asserted-by":"publisher","first-page":"23","DOI":"10.1016\/S0009-8981(03)00082-2","article-title":"Plasma homocysteine and its relationships with atherothrombotic markers in psoriatic patients","volume":"332","author":"Kural","year":"2003","journal-title":"Clin. Chim. Acta"},{"key":"2021111619540641500_B10","doi-asserted-by":"publisher","first-page":"1165","DOI":"10.1111\/j.1365-2133.2006.07503.x","article-title":"Plasma homocysteine and folate levels in patients with chronic plaque psoriasis","volume":"155","author":"Malerba","year":"2006","journal-title":"Br. J. Dermatol."},{"key":"2021111619540641500_B11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.2340\/00015555-0456","article-title":"Inflammation and hypercoagulable state in adult psoriatic men","volume":"88","author":"Karabudak","year":"2008","journal-title":"Acta Derm. Venereol."},{"key":"2021111619540641500_B12","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1177\/039463201002300327","article-title":"Homocysteine, vitamin B12 and folic acid levels in psoriatic patients and correlation with disease severity","volume":"23","author":"Brazzelli","year":"2010","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"2021111619540641500_B13","doi-asserted-by":"publisher","first-page":"19","DOI":"10.1111\/j.1365-2230.2010.03877.x","article-title":"Homocysteine status and cardiovascular risk factors in patients with psoriasis: a case-control study","volume":"36","author":"Tobin","year":"2011","journal-title":"Clin. Exp. Dermatol."},{"key":"2021111619540641500_B14","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1007\/s00403-015-1553-3","article-title":"Serum homocysteine, asymmetric dimethyl arginine (ADMA) and other arginine-NO pathway metabolite levels in patients with psoriasis","volume":"307","author":"Bilgi\u00e7","year":"2015","journal-title":"Arch. Dermatol. Res."},{"key":"2021111619540641500_B15","doi-asserted-by":"publisher","first-page":"1781","DOI":"10.1111\/jdv.13023","article-title":"Homocysteine plasma levels in psoriasis patients: our experience and review of the literature","volume":"29","author":"Giannoni","year":"2015","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"2021111619540641500_B16","doi-asserted-by":"publisher","first-page":"276","DOI":"10.7241\/ourd.20163.74","article-title":"Serum levels of homocystiene, vitamin B12 and folic acid in Indian patients with psoriasis: results of a pilot study","volume":"7","author":"Khatri","year":"2016","journal-title":"Our Dermatol Online"},{"key":"2021111619540641500_B17","doi-asserted-by":"publisher","first-page":"4","DOI":"10.3126\/ajms.v8i5.17136","article-title":"Plasma homocysteine levels in patients with Psoriasis","volume":"8","author":"Das","year":"2017","journal-title":"Asian J. Med. Sci."},{"key":"2021111619540641500_B18","first-page":"29","article-title":"Homocysteine Serum Status in Patients with Psoriasis Vulgaris","volume":"10","author":"Shalaby","year":"2017","journal-title":"N. Y. Sci. J."},{"key":"2021111619540641500_B19","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1111\/j.1468-3083.2008.03024.x","article-title":"Homocysteine, vitamin B12 and folic acid levels in psoriasis patients","volume":"23","author":"Cakmak","year":"2009","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"2021111619540641500_B20","first-page":"AB204","article-title":"Investigation of the plasma homocysteine levels in patients with psoriasis","volume":"68","author":"Uslu","year":"2013","journal-title":"J. Am. Acad. Dermatol."},{"key":"2021111619540641500_B21","doi-asserted-by":"publisher","first-page":"503","DOI":"10.1111\/ijd.12397","article-title":"Evaluation of serum sCD40L and homocysteine levels with subclinical atherosclerosis indicators in patients with psoriasis: a pilot study","volume":"53","author":"Erturan","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"2021111619540641500_B22","doi-asserted-by":"publisher","first-page":"386","DOI":"10.1177\/0300060513502891","article-title":"Clinical and laboratory parameters associated with metabolic syndrome in Turkish patients with psoriasis","volume":"42","author":"Akcali","year":"2014","journal-title":"J. Int. Med. Res."},{"key":"2021111619540641500_B23","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1111\/bjd.17034","article-title":"Serum homocysteine, folate and vitamin B(12) levels in patients with psoriasis: a systematic review and meta-analysis","volume":"180","author":"Tsai","year":"2019","journal-title":"Br. J. Dermatol."},{"key":"2021111619540641500_B24","doi-asserted-by":"publisher","first-page":"372","DOI":"10.1007\/s12272-018-1016-4","article-title":"Causes of hyperhomocysteinemia and its pathological significance","volume":"41","author":"Kim","year":"2018","journal-title":"Arch. Pharm. Res."},{"key":"2021111619540641500_B25","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1111\/j.1365-2133.1971.tb02543.x","article-title":"The mechanism of folate deficiency in psoriasis","volume":"84","author":"Fry","year":"1971","journal-title":"Br. J. Dermatol."},{"key":"2021111619540641500_B26","doi-asserted-by":"publisher","first-page":"335","DOI":"10.1111\/j.1365-2133.1973.tb02987.x","article-title":"Study of folate in psoriasis: blood levels, intestinal absorption and cutaneous loss","volume":"89","author":"Touraine","year":"1973","journal-title":"Br. J. Dermatol."},{"key":"2021111619540641500_B27","doi-asserted-by":"publisher","first-page":"1580","DOI":"10.1053\/euhj.2002.3172","article-title":"Smoking and plasma homocysteine","volume":"23","author":"O\u2019Callaghan","year":"2002","journal-title":"Eur. Heart J."},{"key":"2021111619540641500_B28","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1191\/1358863x04vm542oa","article-title":"The associations between smoking, physical activity, dietary habits and plasma homocysteine levels in cardiovascular disease-free people: the \u2018ATTICA\u2019 study","volume":"9","author":"Chrysohoou","year":"2004","journal-title":"Vasc. Med."},{"key":"2021111619540641500_B29","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1080\/13590840500220197","article-title":"Homocysteine and vitamin status in healthy Thai smokers","volume":"15","author":"Suriyaprom","year":"2005","journal-title":"J. Nutr. Environ. Med."},{"key":"2021111619540641500_B30","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1515\/CCLM.2011.062","article-title":"Effect of cigarette smoking on plasma homocysteine concentrations","volume":"49","author":"Haj Mouhamed","year":"2011","journal-title":"Clin. Chem. Lab. Med."},{"key":"2021111619540641500_B31","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1177\/1203475415616073","article-title":"Psoriasis and Smoking: A Systematic Literature Review and Meta-Analysis With Qualitative Analysis of Effect of Smoking on Psoriasis Severity","volume":"20","author":"Richer","year":"2016","journal-title":"J. Cutan. Med. Surg."},{"key":"2021111619540641500_B32","doi-asserted-by":"publisher","first-page":"687","DOI":"10.1111\/j.1530-0277.1993.tb00820.x","article-title":"Elevated plasma homocysteine in alcoholics","volume":"17","author":"Hultberg","year":"1993","journal-title":"Alcohol Clin. Exp. Res."},{"key":"2021111619540641500_B33","doi-asserted-by":"publisher","first-page":"220","DOI":"10.1093\/ajcn\/63.2.220","article-title":"Hyperhomocysteinemia in chronic alcoholism: correlation with folate, vitamin B-12, and vitamin B-6 status","volume":"63","author":"Cravo","year":"1996","journal-title":"Am. J. Clin. Nutr."},{"key":"2021111619540641500_B34","doi-asserted-by":"publisher","first-page":"1522","DOI":"10.1016\/S0140-6736(00)02172-3","article-title":"Effect of consumption of red wine, spirits, and beer on serum homocysteine","volume":"355","author":"van der Gaag","year":"2000","journal-title":"Lancet"},{"key":"2021111619540641500_B35","doi-asserted-by":"publisher","first-page":"628","DOI":"10.1093\/ajcn\/73.3.628","article-title":"Association of folate intake and serum homocysteine in elderly persons according to vitamin supplementation and alcohol use","volume":"73","author":"Koehler","year":"2001","journal-title":"Am. J. Clin. Nutr."},{"key":"2021111619540641500_B36","doi-asserted-by":"publisher","first-page":"189","DOI":"10.1093\/alcalc\/36.3.189","article-title":"Moderate alcohol consumption in social drinkers raises plasma homocysteine levels: a contradiction to the \u2018French Paradox\u2019?","volume":"36","author":"Bleich","year":"2001","journal-title":"Alcohol Alcohol."},{"key":"2021111619540641500_B37","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1743-7075-1-9","article-title":"The J-shape association of ethanol intake with total homocysteine concentrations: the ATTICA study","volume":"1","author":"Pitsavos","year":"2004","journal-title":"Nutr. Metab. (Lond)"},{"key":"2021111619540641500_B38","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.alcohol.2005.12.005","article-title":"Alcohol consumption and plasma homocysteine","volume":"37","author":"Sakuta","year":"2005","journal-title":"Alcohol"},{"key":"2021111619540641500_B39","doi-asserted-by":"publisher","first-page":"334","DOI":"10.1097\/01.ALC.0000156083.91214.59","article-title":"Evidence of increased homocysteine levels in alcoholism: the Franconian alcoholism research studies (FARS)","volume":"29","author":"Bleich","year":"2005","journal-title":"Alcohol Clin. Exp. Res."},{"key":"2021111619540641500_B40","doi-asserted-by":"publisher","first-page":"881","DOI":"10.1093\/qjmed\/hcn112","article-title":"Alcohol increases homocysteine and reduces B vitamin concentration in healthy male volunteers\u2013a randomized, crossover intervention study","volume":"101","author":"Gibson","year":"2008","journal-title":"QJM"},{"key":"2021111619540641500_B41","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1111\/jdv.12164","article-title":"Alcohol consumption and psoriasis: a systematic literature review","volume":"27","author":"Brenaut","year":"2013","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"2021111619540641500_B42","doi-asserted-by":"publisher","first-page":"e54","DOI":"10.1038\/nutd.2012.26","article-title":"The association between psoriasis and obesity: a systematic review and meta-analysis of observational studies","volume":"2","author":"Armstrong","year":"2012","journal-title":"Nutr. Diabetes"},{"key":"2021111619540641500_B43","doi-asserted-by":"publisher","first-page":"1163","DOI":"10.1007\/s10654-018-0366-z","article-title":"Body mass index, abdominal fatness, weight gain and the risk of psoriasis: a systematic review and dose-response meta-analysis of prospective studies","volume":"33","author":"Aune","year":"2018","journal-title":"Eur. J. Epidemiol."},{"key":"2021111619540641500_B44","doi-asserted-by":"publisher","first-page":"403","DOI":"10.1016\/S0899-9007(01)00803-6","article-title":"Homocysteine and psychological traits: a study in obesity","volume":"18","author":"Marchesini","year":"2002","journal-title":"Nutrition"},{"key":"2021111619540641500_B45","doi-asserted-by":"publisher","first-page":"8","DOI":"10.1024\/0300-9831.73.1.8","article-title":"Serum homocysteine, B12 and folic acid concentration in Thai overweight and obese subjects","volume":"73","author":"Tungtrongchitr","year":"2003","journal-title":"Int. J. Vitam. Nutr. Res."},{"key":"2021111619540641500_B46","doi-asserted-by":"publisher","first-page":"405","DOI":"10.1016\/S0009-9120(03)00059-6","article-title":"Plasma homocysteine levels in obese and non-obese subjects with or without hypertension; its relationship with oxidative stress and copper","volume":"36","author":"Konuko\u011flu","year":"2003","journal-title":"Clin. Biochem."},{"key":"2021111619540641500_B47","first-page":"491","article-title":"Relationship between body mass index, lipids and homocysteine levels in university students","volume":"57","author":"Sanlier","year":"2007","journal-title":"J. Pak. Med. Assoc."},{"key":"2021111619540641500_B48","first-page":"156","article-title":"Plasma homocysteine in obese, overweight and normal weight hypertensives and normotensives","volume":"61","author":"Karatela","year":"2009","journal-title":"Indian Heart J."},{"key":"2021111619540641500_B49","doi-asserted-by":"publisher","first-page":"935","DOI":"10.1007\/s13312-017-1185-0","article-title":"A Prospective Study of Homocysteine and its relation to Body Mass Index and Lipid Profile in School Children","volume":"54","author":"Kumar","year":"2017","journal-title":"Indian Pediatr."},{"key":"2021111619540641500_B50","doi-asserted-by":"publisher","first-page":"E1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis Pathogenesis and Treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B51","doi-asserted-by":"publisher","first-page":"423","DOI":"10.1242\/dmm.009092","article-title":"Putting together the psoriasis puzzle: an update on developing targeted therapies","volume":"5","author":"Johnson-Huang","year":"2012","journal-title":"Dis. Model Mech."},{"key":"2021111619540641500_B52","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/S0891-5849(98)00194-4","article-title":"Reactive oxygen species activate human peripheral blood dendritic cells","volume":"26","author":"Rutault","year":"1999","journal-title":"Free Radic. Biol. Med."},{"key":"2021111619540641500_B53","doi-asserted-by":"publisher","first-page":"283","DOI":"10.1189\/jlb.3A0113-033RR","article-title":"The mechanisms of up-regulation of dendritic cell activity by oxidative stress","volume":"96","author":"Batal","year":"2014","journal-title":"J. Leukoc. Biol."},{"key":"2021111619540641500_B54","doi-asserted-by":"publisher","first-page":"E1733","DOI":"10.3390\/ijms17101733","article-title":"The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health","volume":"17","author":"\u0160kovierov\u00e1","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B55","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1080\/10641960802068725","article-title":"Influence of mental stress on the plasma homocysteine level and blood pressure change in young men","volume":"30","author":"Sawai","year":"2008","journal-title":"Clin. Exp. Hypertens."},{"key":"2021111619540641500_B56","first-page":"626","article-title":"Psoriasis","volume":"87","author":"Weigle","year":"2013","journal-title":"Am. Fam. Physician"},{"key":"2021111619540641500_B57","doi-asserted-by":"publisher","first-page":"1085","DOI":"10.1111\/jdv.13661","article-title":"Impact of pregnancy and oestrogen on psoriasis and potential therapeutic use of selective oestrogen receptor modulators for psoriasis","volume":"30","author":"Lin","year":"2016","journal-title":"J. Eur. Acad. Dermatol. Venereol."},{"key":"2021111619540641500_B58","doi-asserted-by":"publisher","first-page":"459","DOI":"10.1016\/S1521-6934(03)00009-9","article-title":"Homocysteine and pregnancy","volume":"17","author":"Hague","year":"2003","journal-title":"Best Pract. Res. Clin. Obstet. Gynaecol."},{"key":"2021111619540641500_B59","doi-asserted-by":"publisher","first-page":"18","DOI":"10.1186\/s12967-014-0372-1","article-title":"Nutrition and psoriasis: is there any association between the severity of the disease and adherence to the Mediterranean diet?","volume":"13","author":"Barrea","year":"2015","journal-title":"J. Transl. Med."},{"key":"2021111619540641500_B60","doi-asserted-by":"publisher","first-page":"603","DOI":"10.1080\/09637486.2018.1547688","article-title":"The association between homocysteine levels, Mediterranean diet and cardiovascular disease: a case-control study","volume":"70","author":"Foscolou","year":"2019","journal-title":"Int. J. Food Sci. Nutr."},{"key":"2021111619540641500_B61","doi-asserted-by":"publisher","first-page":"1035","DOI":"10.1016\/S0008-6363(01)00541-7","article-title":"Oxidant stress mechanism of homocysteine potentiating Con A-induced proliferation in murine splenic T lymphocytes","volume":"53","author":"Zhang","year":"2002","journal-title":"Cardiovasc. Res."},{"key":"2021111619540641500_B62","doi-asserted-by":"publisher","first-page":"7692024","DOI":"10.1155\/2016\/7692024","article-title":"T Helper Cell Subsets in Clinical Manifestations of Psoriasis","volume":"2016","author":"Diani","year":"2016","journal-title":"J. Immunol. Res."},{"key":"2021111619540641500_B63","doi-asserted-by":"publisher","first-page":"302","DOI":"10.1038\/cmi.2012.15","article-title":"New insights of T cells in the pathogenesis of psoriasis","volume":"9","author":"Cai","year":"2012","journal-title":"Cell Mol. Immunol."},{"key":"2021111619540641500_B64","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1016\/j.mad.2003.11.013","article-title":"The immunoregulatory effects of homocysteine and its intermediates on T-lymphocyte function","volume":"125","author":"Dawson","year":"2004","journal-title":"Mech. Ageing Dev."},{"key":"2021111619540641500_B65","first-page":"585","article-title":"Immunoregulatory effects of homocysteine on cardiovascular diseases","volume":"59","author":"Dai","year":"2007","journal-title":"Sheng Li Xue Bao"},{"key":"2021111619540641500_B66","doi-asserted-by":"publisher","first-page":"155","DOI":"10.1093\/cvr\/cvp182","article-title":"Regulatory T cells ameliorate hyperhomocysteinaemia-accelerated atherosclerosis in apoE-\/- mice","volume":"84","author":"Feng","year":"2009","journal-title":"Cardiovasc. Res."},{"key":"2021111619540641500_B67","doi-asserted-by":"publisher","first-page":"349","DOI":"10.1093\/cvr\/cvs330","article-title":"CTLA4-IgG ameliorates homocysteine-accelerated atherosclerosis by inhibiting T-cell overactivation in apoE(-\/-) mice","volume":"97","author":"Ma","year":"2013","journal-title":"Cardiovasc. Res."},{"key":"2021111619540641500_B68","doi-asserted-by":"publisher","first-page":"3339","DOI":"10.1007\/s10620-018-5177-2","article-title":"Effect of Homocysteine on the Differentiation of CD4(+) T Cells into Th17 Cells","volume":"63","author":"Gao","year":"2018","journal-title":"Dig. Dis. Sci."},{"key":"2021111619540641500_B69","doi-asserted-by":"publisher","first-page":"134","DOI":"10.1159\/000353398","article-title":"Importance of regulatory T cells in the pathogenesis of psoriasis: review of the literature","volume":"227","author":"Mattozzi","year":"2013","journal-title":"Dermatology"},{"key":"2021111619540641500_B70","doi-asserted-by":"publisher","first-page":"1989","DOI":"10.1093\/eurheartj\/ehr425","article-title":"Psoriasis and atherosclerosis: two plaques, one syndrome?","volume":"33","author":"Flammer","year":"2012","journal-title":"Eur. Heart J."},{"key":"2021111619540641500_B71","doi-asserted-by":"publisher","first-page":"E179","DOI":"10.3390\/ijms19010179","article-title":"Scanning the Immunopathogenesis of Psoriasis","volume":"19","author":"Chiricozzi","year":"2018","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B72","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1016\/j.atherosclerosis.2003.11.005","article-title":"Homocysteine enhances superoxide anion release and NADPH oxidase assembly by human neutrophils. Effects on MAPK activation and neutrophil migration","volume":"172","author":"Alvarez-Maqueda","year":"2004","journal-title":"Atherosclerosis."},{"key":"2021111619540641500_B73","doi-asserted-by":"publisher","first-page":"84","DOI":"10.5114\/pdia.2014.40920","article-title":"Chemokines and cytokines network in the pathogenesis of the inflammatory skin diseases: atopic dermatitis, psoriasis and skin mastocytosis","volume":"31","author":"Nedoszytko","year":"2014","journal-title":"Postepy Dermatol. Alergol."},{"key":"2021111619540641500_B74","doi-asserted-by":"publisher","first-page":"136","DOI":"10.1016\/j.numecd.2009.08.003","article-title":"Associations of plasma homocysteine level with brachial-ankle pulse wave velocity, LDL atherogenicity, and inflammation profile in healthy men","volume":"21","author":"Yun","year":"2011","journal-title":"Nutr. Metab. Cardiovasc. Dis."},{"key":"2021111619540641500_B75","doi-asserted-by":"publisher","first-page":"358","DOI":"10.1007\/s10517-015-2962-1","article-title":"Lymphocyte Subpopulations and Cytokine Levels in Experimental Hyperhomocysteinemia","volume":"159","author":"Fefelova","year":"2015","journal-title":"Bull. Exp. Biol. Med."},{"key":"2021111619540641500_B76","doi-asserted-by":"publisher","first-page":"199","DOI":"10.1007\/s11011-010-9188-8","article-title":"Increased inflammatory markers in brain and blood of rats subjected to acute homocysteine administration","volume":"25","author":"da Cunha","year":"2010","journal-title":"Metab. Brain Dis."},{"key":"2021111619540641500_B77","doi-asserted-by":"publisher","first-page":"1660","DOI":"10.1007\/s11064-012-0769-2","article-title":"Chronic hyperhomocysteinemia increases inflammatory markers in hippocampus and serum of rats","volume":"37","author":"da Cunha","year":"2012","journal-title":"Neurochem. Res."},{"key":"2021111619540641500_B78","doi-asserted-by":"publisher","first-page":"589","DOI":"10.1007\/s12035-014-8660-6","article-title":"Mild hyperhomocysteinemia increases brain acetylcholinesterase and proinflammatory cytokine levels in different tissues","volume":"50","author":"Scherer","year":"2014","journal-title":"Mol. Neurobiol."},{"key":"2021111619540641500_B79","doi-asserted-by":"publisher","first-page":"37","DOI":"10.1161\/CIRCRESAHA.112.269472","article-title":"Severe hyperhomocysteinemia promotes bone marrow-derived and resident inflammatory monocyte differentiation and atherosclerosis in LDLr\/CBS-deficient mice","volume":"111","author":"Zhang","year":"2012","journal-title":"Circ. Res."},{"key":"2021111619540641500_B80","doi-asserted-by":"publisher","first-page":"2622","DOI":"10.2337\/diacare.26.9.2622","article-title":"Relationships of plasma interleukin-18 concentrations to hyperhomocysteinemia and carotid intimal-media wall thickness in patients with type 2 diabetes","volume":"26","author":"Aso","year":"2003","journal-title":"Diabetes Care"},{"key":"2021111619540641500_B81","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1002\/biof.5520230202","article-title":"Homocysteine is positively associated with cytokine IL-18 plasma levels in coronary artery bypass surgery patients","volume":"23","author":"McLachlan","year":"2005","journal-title":"Biofactors"},{"key":"2021111619540641500_B82","doi-asserted-by":"publisher","first-page":"1148","DOI":"10.1093\/rheumatology\/kel082","article-title":"Relationship of plasma interleukin-18 concentrations to traditional and non-traditional cardiovascular risk factors in patients with systemic lupus erythematosus","volume":"45","author":"Tso","year":"2006","journal-title":"Rheumatology (Oxford)"},{"key":"2021111619540641500_B83","doi-asserted-by":"publisher","first-page":"922","DOI":"10.1038\/labinvest.2017.30","article-title":"Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice","volume":"97","author":"Wang","year":"2017","journal-title":"Lab. Invest."},{"key":"2021111619540641500_B84","doi-asserted-by":"publisher","first-page":"534","DOI":"10.1258\/000456303322326452","article-title":"Effect of homocysteine on cytokine production by human endothelial cells and monocytes","volume":"40","author":"Dalal","year":"2003","journal-title":"Ann. Clin. Biochem."},{"key":"2021111619540641500_B85","doi-asserted-by":"publisher","first-page":"994","DOI":"10.1016\/j.nut.2005.01.011","article-title":"Homocysteine at pathophysiologic concentrations activates human monocyte and induces cytokine expression and inhibits macrophage migration inhibitory factor expression","volume":"21","author":"Su","year":"2005","journal-title":"Nutrition"},{"key":"2021111619540641500_B86","first-page":"1419","article-title":"Homocysteine induces production of monocyte chemoattractant protein-1 and interleukin-8 in cultured human whole blood","volume":"25","author":"Zeng","year":"2004","journal-title":"Acta Pharmacol. Sin."},{"key":"2021111619540641500_B87","doi-asserted-by":"publisher","first-page":"E739","DOI":"10.3390\/ijms20030739","article-title":"Advances in Understanding the Immunological Pathways in Psoriasis","volume":"20","author":"Georgescu","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B88","first-page":"17","article-title":"The role of regulatory T cells and anti-inflammatory cytokines in psoriasis","volume":"27","author":"Owczarczyk-Saczonek","year":"2018","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"2021111619540641500_B89","doi-asserted-by":"publisher","DOI":"10.1111\/1348-0421.12605","article-title":"Clinical Significance of Decreased Interleukin-35 Expression in Patients with Psoriasis","author":"Li","year":"2018","journal-title":"Microbiol. Immunol."},{"key":"2021111619540641500_B90","doi-asserted-by":"publisher","first-page":"575","DOI":"10.2147\/TCRM.S125595","article-title":"Narrowband ultraviolet B light treatment changes plasma concentrations of MMP-3, MMP-9 and TIMP-3 in psoriatic patients","volume":"13","author":"G\u0142a\u017cewska","year":"2017","journal-title":"Ther. Clin. Risk Manag."},{"key":"2021111619540641500_B91","doi-asserted-by":"publisher","first-page":"1731","DOI":"10.1161\/01.STR.0000226465.84561.cb","article-title":"Impaired inhibitory effect of interleukin-10 on the balance between matrix metalloproteinase-9 and its inhibitor in mononuclear cells from hyperhomocysteinemic subjects","volume":"37","author":"Holven","year":"2006","journal-title":"Stroke"},{"key":"2021111619540641500_B92","doi-asserted-by":"publisher","first-page":"13559","DOI":"10.1073\/pnas.1413390111","article-title":"Impaired hydrogen sulfide synthesis and IL-10 signaling underlie hyperhomocysteinemia-associated exacerbation of colitis","volume":"111","author":"Flannigan","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"2021111619540641500_B93","first-page":"17","article-title":"The role of regulatory T cells and anti-inflammatory cytokines in psoriasis","volume":"27","author":"Owczarczyk-Saczonek","year":"2018","journal-title":"Acta Dermatovenerol Alp Pannonica Adriat"},{"key":"2021111619540641500_B94","doi-asserted-by":"publisher","first-page":"89","DOI":"10.1016\/j.jdermsci.2012.11.002","article-title":"NF-\u03baB: an essential transcription factor in psoriasis","volume":"69","author":"Goldminz","year":"2013","journal-title":"J. Dermatol. Sci."},{"key":"2021111619540641500_B95","doi-asserted-by":"publisher","first-page":"817","DOI":"10.1042\/bj3520817","article-title":"Homocysteine stimulates nuclear factor kappaB activity and monocyte chemoattractant protein-1 expression in vascular smooth-muscle cells: a possible role for protein kinase C","volume":"352","author":"Wang","year":"2000","journal-title":"Biochem. J."},{"key":"2021111619540641500_B96","doi-asserted-by":"publisher","first-page":"H2840","DOI":"10.1152\/ajpheart.2001.280.6.H2840","article-title":"Homocysteine induces monocyte chemoattractant protein-1 expression by activating NF-kappaB in THP-1 macrophages","volume":"280","author":"Wang","year":"2001","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"2021111619540641500_B97","doi-asserted-by":"publisher","first-page":"28","DOI":"10.1161\/01.RES.0000108264.67601.2C","article-title":"Hyperhomocysteinemia activates nuclear factor-kappaB in endothelial cells via oxidative stress","volume":"94","author":"Au-Yeung","year":"2004","journal-title":"Circ. Res."},{"key":"2021111619540641500_B98","first-page":"117","article-title":"A novel rat model of heart failure induced by high methionine diet showing evidence of association between hyperhomocysteinemia and activation of NF-kappaB","volume":"8","author":"Liu","year":"2016","journal-title":"Am. J. Transl. Res."},{"key":"2021111619540641500_B99","doi-asserted-by":"publisher","first-page":"570","DOI":"10.1111\/ijd.12050","article-title":"Role of NF-\u03baB in the pathogenesis of psoriasis elucidated by its staining in skin biopsy specimens","volume":"53","author":"Moorchung","year":"2014","journal-title":"Int. J. Dermatol."},{"key":"2021111619540641500_B100","doi-asserted-by":"publisher","first-page":"17023","DOI":"10.1038\/sigtrans.2017.23","article-title":"NF-\u03baB signaling in inflammation","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct Target Ther."},{"key":"2021111619540641500_B101","doi-asserted-by":"publisher","first-page":"E1733","DOI":"10.3390\/ijms17101733","article-title":"The Molecular and Cellular Effect of Homocysteine Metabolism Imbalance on Human Health","volume":"17","author":"\u0160kovierov\u00e1","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B102","doi-asserted-by":"publisher","first-page":"585","DOI":"10.3109\/10715762.2016.1162301","article-title":"Oxidative stress in psoriasis and potential therapeutic use of antioxidants","volume":"50","author":"Lin","year":"2016","journal-title":"Free Radic. Res."},{"key":"2021111619540641500_B103","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1016\/j.bcp.2012.10.019","article-title":"Biology and therapeutic potential of hydrogen sulfide and hydrogen sulfide-releasing chimeras","volume":"85","author":"Kashfi","year":"2013","journal-title":"Biochem. Pharmacol."},{"key":"2021111619540641500_B104","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1007\/s12013-010-9079-y","article-title":"Homocysteine to hydrogen sulfide or hypertension","volume":"57","author":"Sen","year":"2010","journal-title":"Cell Biochem. Biophys."},{"key":"2021111619540641500_B105","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1007\/s00726-007-0011-8","article-title":"Hydrogen sulfide inhibits myocardial injury induced by homocysteine in rats","volume":"34","author":"Chang","year":"2008","journal-title":"Amino Acids"},{"key":"2021111619540641500_B106","doi-asserted-by":"publisher","first-page":"434","DOI":"10.1002\/biof.1354","article-title":"Hydrogen sulfide attenuates homocysteine-induced cognitive deficits and neurochemical alterations by improving endogenous hydrogen sulfide levels","volume":"43","author":"Kumar","year":"2017","journal-title":"Biofactors"},{"key":"2021111619540641500_B107","doi-asserted-by":"publisher","first-page":"3007","DOI":"10.1002\/jcp.27120","article-title":"Cerebroprotective effects of hydrogen sulfide in homocysteine-induced neurovascular permeability: Involvement of oxidative stress, arginase, and matrix metalloproteinase-9","volume":"234","author":"Nath","year":"2019","journal-title":"J. Cell. Physiol."},{"key":"2021111619540641500_B108","doi-asserted-by":"publisher","first-page":"583","DOI":"10.1111\/bph.14446","article-title":"Regulators of the transsulfuration pathway","volume":"176","author":"Sbodio","year":"2019","journal-title":"Br. J. Pharmacol."},{"key":"2021111619540641500_B109","doi-asserted-by":"publisher","first-page":"2746873","DOI":"10.1155\/2018\/2746873","article-title":"Hydrogen Sulfide Ameliorates Developmental Impairments of Rat Offspring with Prenatal Hyperhomocysteinemia","volume":"2018","author":"Yakovleva","year":"2018","journal-title":"Oxid. Med. Cell. Longev"},{"key":"2021111619540641500_B110","doi-asserted-by":"publisher","first-page":"288","DOI":"10.1080\/10715762.2018.1431626","article-title":"Hydrogen sulfide increases glutathione biosynthesis, and glucose uptake and utilisation in C(2)C(12) mouse myotubes","volume":"52","author":"Parsanathan","year":"2018","journal-title":"Free Radic. Res."},{"key":"2021111619540641500_B111","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1620\/tjem.228.325","article-title":"Psoriasis is associated with low serum levels of hydrogen sulfide, a potential anti-inflammatory molecule","volume":"228","author":"Alshorafa","year":"2012","journal-title":"Tohoku J. Exp. Med."},{"key":"2021111619540641500_B112","doi-asserted-by":"publisher","first-page":"17","DOI":"10.1177\/247553031016a00403","article-title":"Which Psoriasis Patients Develop Psoriatic Arthritis?","volume":"16","author":"Busse","year":"2010","journal-title":"Psoriasis Forum"},{"key":"2021111619540641500_B113","doi-asserted-by":"publisher","first-page":"221","DOI":"10.1093\/rheumatology\/kev296","article-title":"HLA-B27 and psoriatic disease: a modern view of an old relationship","volume":"55","author":"Queiro","year":"2016","journal-title":"Rheumatology (Oxford)"},{"key":"2021111619540641500_B114","doi-asserted-by":"publisher","first-page":"14","DOI":"10.1007\/s00296-003-0323-2","article-title":"Anemia, serum vitamin B12, and folic acid in patients with rheumatoid arthritis, psoriatic arthritis, and systemic lupus erythematosus","volume":"24","author":"Segal","year":"2004","journal-title":"Rheumatol. Int."},{"key":"2021111619540641500_B115","doi-asserted-by":"publisher","first-page":"E1475","DOI":"10.3390\/ijms20061475","article-title":"Psoriasis Pathogenesis and Treatment","volume":"20","author":"Rendon","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619540641500_B116","doi-asserted-by":"publisher","first-page":"392","DOI":"10.5114\/pdia.2014.47121","article-title":"The possibilities and principles of methotrexate treatment of psoriasis - the updated knowledge","volume":"31","author":"Czarnecka-Operacz","year":"2014","journal-title":"Postepy Dermatol. Alergol."},{"key":"2021111619540641500_B117","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1136\/ard.2003.019828","article-title":"Intermittent rises in plasma homocysteine in patients with rheumatoid arthritis treated with higher dose methotrexate","volume":"64","author":"Hoekstra","year":"2005","journal-title":"Ann. Rheum. Dis."},{"key":"2021111619540641500_B118","doi-asserted-by":"publisher","first-page":"965385","DOI":"10.1155\/2012\/965385","article-title":"A review of psoriasis, a known risk factor for cardiovascular disease and its impact on folate and homocysteine metabolism","volume":"2012","author":"McDonald","year":"2012","journal-title":"J. Nutr. Metab."},{"key":"2021111619540641500_B119","first-page":"2374","article-title":"Folate, homocysteine, and cobalamin status in patients with rheumatoid arthritis treated with methotrexate, and the effect of low dose folic acid supplement","volume":"31","author":"Hornung","year":"2004","journal-title":"J. Rheumatol."},{"key":"2021111619540641500_B120","doi-asserted-by":"publisher","first-page":"925","DOI":"10.1016\/j.jaad.2010.02.063","article-title":"The use of cyclosporine in dermatology: part I","volume":"63","author":"Amor","year":"2010","journal-title":"J. Am. Acad. Dermatol."},{"key":"2021111619540641500_B121","doi-asserted-by":"publisher","first-page":"509","DOI":"10.1097\/00007890-199602150-00034","article-title":"Hyperhomocysteinemia in cyclosporine-treated renal transplant recipients","volume":"61","author":"Arnadottir","year":"1996","journal-title":"Transplantation"},{"key":"2021111619540641500_B122","first-page":"462","article-title":"Determinants of fasting total serum homocysteine levels in liver transplant recipients","volume":"4","author":"Akoglu","year":"2006","journal-title":"Exp. Clin. Transplant."},{"key":"2021111619540641500_B123","doi-asserted-by":"publisher","first-page":"1795","DOI":"10.1007\/s00726-014-1741-z","article-title":"Effects of physical activity and training programs on plasma homocysteine levels: a systematic review","volume":"46","author":"e Silva Ade","year":"2014","journal-title":"Amino Acids"},{"key":"2021111619540641500_B124","first-page":"100","article-title":"Trial of folic acid therapy in psoriasis","volume":"47","author":"Dawson","year":"1978","journal-title":"Ulster Med. J."},{"key":"2021111619540641500_B125","doi-asserted-by":"publisher","first-page":"1","DOI":"10.15761\/JTS.1000193","article-title":"Cases of psoriasis improved by lowering homocysteine using 4-7 mg folic acid, vitamins B6 and B12 previously worsened using 1-2 mg daily folic acid, B6 and B12 folic acid","volume":"3","author":"Aronson","year":"2017","journal-title":"J. Transl. Sci."},{"key":"2021111619540641500_B126","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1080\/09546630701247930","article-title":"Folic acid in general medicine and dermatology","volume":"18","author":"Gisondi","year":"2007","journal-title":"J. Dermatolog. Treat."},{"key":"2021111619540641500_B127","doi-asserted-by":"publisher","first-page":"107","DOI":"10.1097\/00001610-199705000-00009","article-title":"Common vitamin B complex agents and folic acid: Part IV. Leucovorin calcium (citrovorum factor, folinic acid [wellcovorin])","volume":"20","author":"Claussen","year":"1997","journal-title":"Gastroenterol Nurs."},{"key":"2021111619540641500_B128","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1177\/039463201002300229","article-title":"Safety and efficacy of calcium folinate in psoriasis: an observational study","volume":"23","author":"Carlesimo","year":"2010","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"2021111619540641500_B129","doi-asserted-by":"publisher","first-page":"1729","DOI":"10.1136\/bmj.2.5321.1729","article-title":"Is vitamin B12 of value in psoriasis?","volume":"2","author":"Baker","year":"1962","journal-title":"Br. Med. J."},{"key":"2021111619540641500_B130","doi-asserted-by":"publisher","first-page":"611","DOI":"10.1136\/bmj.1.5330.611","article-title":"Vitamin B 12 in P psoriasis","volume":"1","author":"Carslaw","year":"1963","journal-title":"Br. Med. J."},{"key":"2021111619540641500_B131","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1111\/j.1365-2133.1969.tb15973.x","article-title":"The vitamin B12 level in psoriatic skin and serum","volume":"81","author":"Stankler","year":"1969","journal-title":"Br. J. Dermatol."},{"key":"2021111619540641500_B132","doi-asserted-by":"publisher","first-page":"141","DOI":"10.1159\/000051729","article-title":"Vitamin B(12) cream containing avocado oil in the therapy of plaque psoriasis","volume":"203","author":"St\u00fccker","year":"2001","journal-title":"Dermatology"},{"key":"2021111619540641500_B133","doi-asserted-by":"publisher","first-page":"439","DOI":"10.1177\/0394632017736674","article-title":"Superiority of a vitamin B(12)-containing emollient compared to a standard emollient in the maintenance treatment of mild-to-moderate plaque psoriasis","volume":"30","author":"Del Duca","year":"2017","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"2021111619540641500_B134","doi-asserted-by":"publisher","first-page":"84","DOI":"10.4103\/0973-7847.194044","article-title":"Overviews of Biological Importance of Quercetin: A Bioactive Flavonoid","volume":"10","author":"Anand David","year":"2016","journal-title":"Pharmacogn. Rev."},{"key":"2021111619540641500_B135","doi-asserted-by":"publisher","first-page":"661","DOI":"10.1016\/j.nut.2012.10.012","article-title":"Quercetin reduces serum homocysteine level in rats fed a methionine-enriched diet","volume":"29","author":"Meng","year":"2013","journal-title":"Nutrition"},{"key":"2021111619540641500_B136","doi-asserted-by":"publisher","first-page":"815210","DOI":"10.1155\/2015\/815210","article-title":"Quercetin Increases Hepatic Homocysteine Remethylation and Transsulfuration in Rats Fed a Methionine-Enriched Diet","volume":"2015","author":"Meng","year":"2015","journal-title":"Biomed. Res. Int."},{"key":"2021111619540641500_B137","doi-asserted-by":"publisher","first-page":"291","DOI":"10.1016\/j.nut.2016.07.014","article-title":"Protective effect of quercetin on homocysteine-induced oxidative stress","volume":"33","author":"\u00c7elik","year":"2017","journal-title":"Nutrition"},{"key":"2021111619540641500_B138","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/S2221-1691(12)60021-5","article-title":"Screening of flavonoid \u201cquercetin\u201d from the rhizome of Smilax china Linn. for anti-psoriatic activity","volume":"2","author":"Vijayalakshmi","year":"2012","journal-title":"Asian Pac. J. Trop. Biomed."},{"key":"2021111619540641500_B139","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.intimp.2017.04.022","article-title":"Quercetin ameliorates imiquimod-induced psoriasis-like skin inflammation in mice via the NF-\u03baB pathway","volume":"48","author":"Chen","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"2021111619540641500_B140","doi-asserted-by":"publisher","first-page":"e13065","DOI":"10.1097\/MD.0000000000013065","article-title":"The biologic effect of hydrogen sulfide and its function in various diseases","volume":"97","author":"Xiao","year":"2018","journal-title":"Medicine (Baltimore)."},{"key":"2021111619540641500_B141","doi-asserted-by":"publisher","first-page":"1392","DOI":"10.1080\/14756366.2018.1509211","article-title":"The new H(2)S-releasing compound ACS94 exerts protective effects through the modulation of thiol homoeostasis","volume":"33","author":"Giustarini","year":"2018","journal-title":"J. Enzyme Inhib. Med. Chem."},{"key":"2021111619540641500_B142","doi-asserted-by":"publisher","first-page":"11788","DOI":"10.1039\/C4CC00968A","article-title":"Hydrogen sulfide (H2S) releasing agents: chemistry and biological applications","volume":"50","author":"Zhao","year":"2014","journal-title":"Chem. Commun. (Camb.)"},{"key":"2021111619540641500_B143","doi-asserted-by":"publisher","first-page":"420","DOI":"10.1016\/j.taap.2011.09.026","article-title":"Hydrogen sulfide mediates the anti-survival effect of sulforaphane on human prostate cancer cells","volume":"257","author":"Pei","year":"2011","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"2021111619540641500_B144","doi-asserted-by":"publisher","first-page":"8108549","DOI":"10.1155\/2016\/8108549","article-title":"Hydrogen Sulfide Signaling Axis as a Target for Prostate Cancer Therapeutics","volume":"2016","author":"Liu","year":"2016","journal-title":"Prostate Cancer"},{"key":"2021111619540641500_B145","doi-asserted-by":"publisher","first-page":"2226","DOI":"10.1002\/ptr.6159","article-title":"Effect of glucoraphanin and sulforaphane against chemotherapy-induced neuropathic pain: Kv7 potassium channels modulation by H(2) S release in vivo","volume":"32","author":"Lucarini","year":"2018","journal-title":"Phytother. Res."},{"key":"2021111619540641500_B146","doi-asserted-by":"publisher","first-page":"735","DOI":"10.1007\/s00011-012-0465-3","article-title":"Isothiocyanates inhibit psoriasis-related proinflammatory factors in human skin","volume":"61","author":"Yehuda","year":"2012","journal-title":"Inflamm. Res."},{"key":"2021111619540641500_B147","doi-asserted-by":"publisher","first-page":"447.e4","DOI":"10.1016\/j.chembiol.2018.01.011","article-title":"N-Acetyl Cysteine Functions as a Fast-Acting Antioxidant by Triggering Intracellular H(2)S and Sulfane Sulfur Production","volume":"25","author":"Ezeri\u0146a","year":"2018","journal-title":"Cell Chem. Biol."},{"key":"2021111619540641500_B148","doi-asserted-by":"publisher","first-page":"e000600","DOI":"10.1136\/openhrt-2017-000600","article-title":"Boosting endogenous production of vasoprotective hydrogen sulfide via supplementation with taurine and N-acetylcysteine: a novel way to promote cardiovascular health","volume":"4","author":"DiNicolantonio","year":"2017","journal-title":"Open Heart"},{"key":"2021111619540641500_B149","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1189\/jlb.5BT0615-234R","article-title":"At the Bedside: Neutrophil extracellular traps (NETs) as targets for biomarkers and therapies in autoimmune diseases","volume":"99","author":"Barnado","year":"2016","journal-title":"J. Leukoc. Biol."},{"key":"2021111619540641500_B150","doi-asserted-by":"publisher","first-page":"2606","DOI":"10.1038\/jid.2008.122","article-title":"Reactive oxygen species in tumor necrosis factor-alpha-activated primary human keratinocytes: implications for psoriasis and inflammatory skin disease","volume":"128","author":"Young","year":"2008","journal-title":"J. Invest. Dermatol."},{"key":"2021111619540641500_B151","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1016\/j.bcp.2017.11.014","article-title":"A review of hydrogen sulfide (H(2)S) donors: Chemistry and potential therapeutic applications","volume":"149","author":"Powell","year":"2018","journal-title":"Biochem. Pharmacol."},{"key":"2021111619540641500_B152","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1016\/j.phrs.2012.07.002","article-title":"Hydrogen sulfide modulates the release of nitric oxide and VEGF in human keratinocytes","volume":"66","author":"Merighi","year":"2012","journal-title":"Pharmacol. Res."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20190867\/860648\/bsr-2019-0867.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20190867\/860648\/bsr-2019-0867.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,22]],"date-time":"2023-09-22T09:50:35Z","timestamp":1695376235000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/39\/11\/BSR20190867\/220983\/Homocysteine-and-psoriasis"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,11]]},"references-count":152,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2019,11,29]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20190867","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,11]]},"published":{"date-parts":[[2019,11]]},"article-number":"BSR20190867"}}