{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T16:08:15Z","timestamp":1792598895097,"version":"4.5.0"},"reference-count":24,"publisher":"Portland Press Ltd.","issue":"8","license":[{"start":{"date-parts":[[2019,9,19]],"date-time":"2019-09-19T00:00:00Z","timestamp":1568851200000},"content-version":"vor","delay-in-days":49,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,8,30]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Our study aims to excavate the role of metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in myocardial infarction (MI), especially in an ischemia\/reperfusion injury model and the underlying mechanism involving the MALAT1-miR144 axis. Our results demonstrated that the expression of MALAT1 has a higher level, while miR-144 expression significantly reduced in myocardial tissue after MI and also in left anterior descending (LAD)-ligation mice. This result was confirmed in vitro studies in HL-1 cardiomyocytes followed with hypoxia\/reoxygenation. In addition, overexpression of MALAT1 by MALAT1-pcDNA injection into the mice with LAD increased myocardial apoptosis in vivo, while this effect was attenuated by miR-144 mimic. Bioinformatics analysis exhibits that 3\u2032-UTR of MALAT1 is targeted to the miR-144-3p. Up-regulation miR-144 blunted the hypoxia- or MALAT1-induced cell apoptosis. In conclusion, the expression of MALAT1 was increased, whereas miR-144 expression was down-regulated in the myocardium after AMI. MALAT1 up-regulation plays a critical role in promoting cardiomyocytes apoptosis via targeting miR-144.<\/jats:p>","DOI":"10.1042\/bsr20191103","type":"journal-article","created":{"date-parts":[[2019,6,21]],"date-time":"2019-06-21T16:45:12Z","timestamp":1561135512000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":49,"title":["Long noncoding RNA MALAT1 promotes cardiomyocyte apoptosis after myocardial infarction via targeting miR-144-3p"],"prefix":"10.1042","volume":"39","author":[{"given":"Xiaohong","family":"Gong","sequence":"first","affiliation":[{"name":"Department of Cardiovascular Medicine, Xi\u2019an Central Hospital, Xi\u2019an City 710003, Shaanxi Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2535-744X","authenticated-orcid":false,"given":"Yun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Department of ENT, the First Affiliated Hospital of Xi\u2019an Jiao Tong University, Xi\u2019an City 710061, Shaanxi Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haixia","family":"Chang","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, Xi\u2019an Central Hospital, Xi\u2019an City 710003, Shaanxi Province, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiovascular Medicine, the second Affiliated Hospital of Xi\u2019an Jiao Tong University, Xi\u2019an City 710003, Shaanxi Province, P.R. 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