{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,30]],"date-time":"2026-01-30T04:46:54Z","timestamp":1769748414537,"version":"3.49.0"},"reference-count":89,"publisher":"Portland Press Ltd.","issue":"1","license":[{"start":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T00:00:00Z","timestamp":1576454400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,1,31]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Objectives: FAS plays a critical role in the extrinsic apoptosis pathway in autoimmune diseases. Previous studies investigating the association between FAS gene \u2212670 A\/G and \u22121377 G\/A polymorphisms and the risk of autoimmune diseases reported controversial results. We performed the meta-analysis to evaluate the possible association. Methods: Relevant studies were identified by searching the PubMed, Embase, CNKI, and Wanfang databases up to December 2018. Odds ratios (ORs) and corresponding 95% confidence intervals (CIs) were calculated to determine the association. Results: A total of 43 articles including 67 studies (52 studies for FAS \u2212670 A\/G and 15 studies for \u22121377 G\/A) were included in the meta-analysis. Our meta-analysis showed that the FAS \u2212670 A\/G polymorphism was associated with the risk of autoimmune diseases (GG vs. GA: OR = 1.079, 95% CI = 1.004\u20131.160, P=0.038), especially in Caucasians (GG vs. GA: OR = 1.12, 95% CI = 1.03\u20131.23, P=0.012), Asians (G vs. A: OR = 0.89, 95% CI = 0.83\u20130.96, P=0.002), systemic lupus erythematosus (SLE) (G vs. A: OR = 0.85, 95% CI = 0.77\u20130.94, P=0.001), multiple sclerosis (MS) (GG+GA vs. AA: OR = 0.83, 95% CI = 0.70\u20130.99, P=0.043), systemic sclerosis (SSc) (GG vs. GA: OR = 1.20, 95% CI = 1.07\u20131.36, P=0.003) and Hashimoto\u2019s thyroiditis (HT) (G vs. A: OR = 1.45, 95% CI = 1.10\u20131.90, P=0.008); the FAS \u22121377 G\/A polymorphism was associated with the risk of autoimmune diseases (A vs. G: OR = 1.11, 95% CI = 1.03\u20131.20, P=0.008), especially in Asians (A vs. G: OR = 1.15, 95% CI = 1.05\u20131.25, P=0.002) and high quality studies (A vs. G: OR = 1.14, 95% CI = 1.05\u20131.24, P=0.002). Conclusion: This meta-analysis demonstrated that the FAS \u2013670A\/G and \u20131377 G\/A polymorphisms were associated with the risk of autoimmune diseases.<\/jats:p>","DOI":"10.1042\/bsr20191197","type":"journal-article","created":{"date-parts":[[2019,12,16]],"date-time":"2019-12-16T11:43:03Z","timestamp":1576496583000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Association between<i>FAS<\/i>gene \u2212670 A\/G and \u22121377 G\/A polymorphisms and the risk of autoimmune diseases: a meta-analysis"],"prefix":"10.1042","volume":"40","author":[{"given":"Hongwei","family":"Yan","sequence":"first","affiliation":[{"name":"NHC\/Ministry of Education\/Liaoning Province Key Laboratory of Immunodermatology (China Medical University), Department of Dermatology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuxiao","family":"Hong","sequence":"additional","affiliation":[{"name":"NHC\/Ministry of Education\/Liaoning Province Key Laboratory of Immunodermatology (China Medical University), Department of Dermatology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2249-860X","authenticated-orcid":false,"given":"Yunfei","family":"Cai","sequence":"additional","affiliation":[{"name":"NHC\/Ministry of Education\/Liaoning Province Key Laboratory of Immunodermatology (China Medical University), Department of Dermatology, The First Hospital of China Medical University, No.155 Nanjing Bei Street, Heping District, Shenyang, Liaoning Province, P.R. China 110001"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,1,6]]},"reference":[{"key":"2021111619575309900_B1","doi-asserted-by":"publisher","first-page":"899","DOI":"10.1038\/90935","article-title":"Autoimmune disease: why and where it occurs","volume":"7","author":"Marrack","year":"2001","journal-title":"Nat. Med."},{"key":"2021111619575309900_B2","doi-asserted-by":"publisher","first-page":"924","DOI":"10.1016\/S1474-4422(06)70552-X","article-title":"Clustering of autoimmune diseases in families with a high-risk for multiple sclerosis: a descriptive study","volume":"5","author":"Barcellos","year":"2006","journal-title":"Lancet Neurol."},{"key":"2021111619575309900_B3","doi-asserted-by":"publisher","first-page":"475","DOI":"10.1007\/s004390050853","article-title":"Familial clustering of rheumatoid arthritis with other autoimmune diseases","volume":"103","author":"Lin","year":"1998","journal-title":"Hum. 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