{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:50:17Z","timestamp":1793609417302,"version":"4.5.0"},"reference-count":23,"publisher":"Portland Press Ltd.","issue":"2","license":[{"start":{"date-parts":[[2020,1,2]],"date-time":"2020-01-02T00:00:00Z","timestamp":1577923200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,2,28]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objective: Depression is a common complication in Type 2 diabetes mellitus (T2DM); however, it has long been underrecognized and undertreated. In the present study, we aimed to evaluate the clinical effects of Wuling capsule, a compound traditional Chinese herbal medicine, on T2DM complicated with depression.<\/jats:p>\n               <jats:p>Method: 66 patients were enrolled and randomly divided into Wuling capsule treatment group and placebo group, and finally 64 cases finished the present study. The levels of FPG, 2hPG, HbAlc, TNF-\u03b1, IL-6, SOD, MDA, Cor, ACTH, HOMA-\u03b2, HOMA-IR and ISI of patients were evaluated and compared. The HAMD scale for patients were recorded.<\/jats:p>\n               <jats:p>Result: After 12-week treatment, the HAMD scale decreased in both groups, and was lower in Wuling capsule group. The level of FPG in Wuling capsule group was significantly lower than in placebo group; however, no obvious changes of 2hPG and HbA1c were found. The levels of IL-6 and TNF-\u03b1 were significantly decreased in both groups, and more obviously in Wuling capsule group. The level of SOD was increased while the level of MDA was decreased significantly in both groups, and the changes were more obviously in Wuling capsule group. The levels of Cor and ACTH were significantly decreased in both groups; however, there was no statistically significance between the two groups. Besides, the comparisons of HOMA-\u03b2, HOMA-IR and ISI between the two groups were not statistically significant.<\/jats:p>\n               <jats:p>Conclusion: Our results suggested that Wuling capsule ameliorated the depression in patients with T2DM, and also improved the state of inflammation and oxidative stress state. These results also strongly indicated the ability of clinical transformation of Wuling capsule in patients with T2DM in the future.<\/jats:p>","DOI":"10.1042\/bsr20191260","type":"journal-article","created":{"date-parts":[[2020,2,18]],"date-time":"2020-02-18T10:48:45Z","timestamp":1582022925000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["The effect of wuling capsule on depression in Type 2 diabetic patients"],"prefix":"10.1042","volume":"40","author":[{"given":"Huanping","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huizhen","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shengju","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xian","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomei","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyan","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Yao","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5462-8651","authenticated-orcid":false,"given":"Qiu","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Endocrinology, Hospital of Chengdu University of Traditional Chinese Medicine, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,2,18]]},"reference":[{"key":"2021111619590042200_B1","first-page":"1289","article-title":"Comparative study of the influence of diabetes distress and depression on treatment adherence in Chinese patients with type 2 diabetes: a cross-sectional survey in the People\u2019s Republic of China","volume":"9","author":"Zhang","year":"2013","journal-title":"Neuropsychiatr. Dis. Treat"},{"key":"2021111619590042200_B2","doi-asserted-by":"publisher","first-page":"577","DOI":"10.1007\/s40265-015-0347-4","article-title":"Depression in type 2 diabetes mellitus: prevalence, impact, and treatment","volume":"75","author":"Semenkovich","year":"2015","journal-title":"Drugs"},{"key":"2021111619590042200_B3","doi-asserted-by":"publisher","first-page":"344","DOI":"10.1016\/j.genhosppsych.2005.04.008","article-title":"Diabetes complications and depression as predictors of health service costs","volume":"275","author":"Simon","year":"2005","journal-title":"Gen. Hosp. Psychiatry"},{"key":"2021111619590042200_B4","doi-asserted-by":"publisher","first-page":"1527","DOI":"10.2147\/NDT.S167608","article-title":"Agomelatine versus fluoxetine in glycemic control and treating depressive and anxiety symptoms in type 2 diabetes mellitus subjects: a single-blind randomized controlled trial","volume":"14","author":"Che","year":"2018","journal-title":"Neuropsychiatr. Dis. Treat"},{"key":"2021111619590042200_B5","first-page":"1434","volume-title":"The second book [M]","author":"Sichuan Institute of traditional Chinese Medicine: Annals of Sichuan traditional Chinese medicine","year":"1960"},{"key":"2021111619590042200_B6","first-page":"13","article-title":"Effects of polysaccharides from C. nigra on macrophage function in mice","volume":"5","author":"Ma Zhizhang","year":"1989","journal-title":"J. Immunol."},{"key":"2021111619590042200_B7","first-page":"640","article-title":"Observation of the curative effect of Wuling capsule in the treatment of post stroke depression","volume":"27","author":"Xu Bin","year":"2007","journal-title":"Chinese J. Integrated Chinese Western Med."},{"key":"2021111619590042200_B8","first-page":"1491","article-title":"Effect of Wuling capsule on PSQI scale and Blood glucose in patients with Type 2 Diabetes Mellitus and Insomnia Guangdong medicine","volume":"33","author":"Shi Lin","year":"2012","journal-title":"Guangdong Medicine"},{"key":"2021111619590042200_B9","first-page":"796","article-title":"Effect of Wuling capsule on PSQI scale and Blood glucose in patients with Type 2 Diabetes Mellitus and Insomnia Shangxi traditional Chinese Medicine","volume":"26","author":"Hu Yuankui","year":"2005","journal-title":"Shaanxi Journal of Traditional Chinese Medicine"},{"key":"2021111619590042200_B10","first-page":"35","article-title":"Investigation and Analysis of related factors affecting Blood glucose Control in Type 2 Diabetes Mellitus","volume":"3","author":"Sun Jijie","year":"2007","journal-title":"J. Practical Diabetes"},{"key":"2021111619590042200_B11","first-page":"128","article-title":"Treatment of depression in patients with diabetes mellitus","volume":"56","author":"Goodnick","year":"1995","journal-title":"J. Clin. Psychiatry"},{"key":"2021111619590042200_B12","first-page":"91","article-title":"Cui Jingqiu Research Progress of Diabetic Depression Syndrome","volume":"42","author":"Yang Kun","year":"2015","journal-title":"Int. J. Psychiatry"},{"key":"2021111619590042200_B13","first-page":"508","article-title":"Research Progress of inflammatory factors and Insulin Resistance","volume":"15","author":"Ruan Danjie","year":"2009","journal-title":"Medical Rev."},{"key":"2021111619590042200_B14","doi-asserted-by":"publisher","first-page":"E844","DOI":"10.1152\/ajpendo.00029.2011","article-title":"Inactivation of TNF-alpha ameliorates diabetic neuropathy in mice","volume":"301","author":"Yamakawa","year":"2011","journal-title":"Am. J. Physiol. Endocrinolmetab"},{"key":"2021111619590042200_B15","doi-asserted-by":"publisher","first-page":"1090","DOI":"10.1056\/NEJMoa0908292","article-title":"Metabolic Disorders Study, Prevalence of diabetes among men and women in China","volume":"362","author":"Yang","year":"2010","journal-title":"N. Engl. J. Med."},{"key":"2021111619590042200_B16","first-page":"61","article-title":"Anti ageing drugs in Ayurveda","volume":"1","author":"Mehta","year":"2012","journal-title":"Herbal Chem."},{"key":"2021111619590042200_B17","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.phymed.2010.08.014","article-title":"The effectiveness and efficacy of Rhodiola rosea L.: a systematic review of randomized clinical trials Phytomedicine","volume":"18","author":"Hung","year":"2011","journal-title":"Phytomedicine"},{"key":"2021111619590042200_B18","doi-asserted-by":"publisher","first-page":"469","DOI":"10.1124\/mol.109.061861","article-title":"cAMP analogs and their metabolites enhance TREK-1 mRNA and K+ current expression in adrenocortical cells","volume":"77","author":"Enyeart","year":"2010","journal-title":"Mol. Pharmacol."},{"key":"2021111619590042200_B19","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1590\/S0100-879X2012007500041","article-title":"Neural regulation of the stress response: glucocorticoid feedback mechanisms","volume":"45","author":"Herman","year":"2012","journal-title":"Braz. J. Med. Biol. Res."},{"key":"2021111619590042200_B20","first-page":"87","article-title":"Diabetes and the hypothalamo-pituitary-adrenal (HPA) axis","volume":"28","author":"Chan","year":"2003","journal-title":"Minerva Endocrinol."},{"key":"2021111619590042200_B21","doi-asserted-by":"publisher","first-page":"714","DOI":"10.1111\/scs.12284","article-title":"Differences in predictors of 5-year survival over a 10-year period in two cohorts of elderly nursing home residents in Sweden","volume":"30","author":"Sund Levander","year":"2016","journal-title":"Scand. J. Caring Sci."},{"key":"2021111619590042200_B22","first-page":"235","article-title":"Changes of hypothalamus-pituitary-adrenal axis function in 60 patients with type 2 diabetes mellitus","volume":"4","author":"Lim Dong-Won","year":"2009","journal-title":"Intern. Med."},{"key":"2021111619590042200_B23","doi-asserted-by":"publisher","first-page":"2439","DOI":"10.1210\/jc.2006-2540","article-title":"Hypothalamic-pituitary-adrenal axis dysregulation and memory impairments in type 2 diabetes","volume":"92","author":"Bruehl","year":"2007","journal-title":"J. Clin. Endocrinol. Metab."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20191260\/868078\/bsr-2019-1260.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20191260\/868078\/bsr-2019-1260.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:39:17Z","timestamp":1637095157000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/2\/BSR20191260\/221737\/The-effect-of-wuling-capsule-on-depression-in-Type"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2]]},"references-count":23,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2,28]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20191260","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,2]]},"published":{"date-parts":[[2020,2]]},"article-number":"BSR20191260"}}