{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T05:51:50Z","timestamp":1781934710675,"version":"3.54.5"},"reference-count":30,"publisher":"Portland Press Ltd.","issue":"6","license":[{"start":{"date-parts":[[2020,5,12]],"date-time":"2020-05-12T00:00:00Z","timestamp":1589241600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,6,26]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background: The study was aimed to investigate the protective effect of Asarum sieboldii Miq. essential oil (AEO) on ovalbumin (OVA)-induced allergic rhinitis (AR) in rats.<\/jats:p>\n               <jats:p>Methods and results: Sixty Sprague\u2013Dawley male rats were randomly divided into six groups (n=10): control, model, cetirizine (Cet, 4.65 g\/kg), and AEO (0.5, 1.5, 3 g\/kg) groups. All animals except the control group received repeated intranasal instillation with 20 \u03bcl of 20% OVA in Al(OH)3 saline solvent for 15 days. The control group was intranasally instilled with 5 mg\/ml of Al(OH)3 instead of the same procedure. In the 15 days, Cet and AEO were orally administrated for 28 days. At the end of the drug administration, 20 \u03bcl of 5% OVA was given to animals to stimulate allergic reaction, then the rat behavioral detection, assessment of the patho-morphological changes in nasal mucosa, and the serum biomarkers were determined. The result showed that AEO could significantly reduce the amount of nasal secretions, sneezing, and the degree of nasal scratching in AR rats with EC50 = 1.5 and 2.8 g\/kg, respectively. The degree of nasal mucosal inflammation in AEO group improved, the levels of immunoglobulin E (IgE), histamine, IL-4, IL-5, IL-17 were decreased, and the level of IFN-\u03b3 was increased obviously with EC50 = 2 g\/kg.<\/jats:p>\n               <jats:p>Conclusion: The study suggested that the possible mechanism might be related with the inhibition of histamine release and regulation of the cytokine levels, which plays an important role in the treatment of AR.<\/jats:p>","DOI":"10.1042\/bsr20191370","type":"journal-article","created":{"date-parts":[[2020,6,2]],"date-time":"2020-06-02T10:11:01Z","timestamp":1591092661000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":22,"title":["Protective effect of <i>Asarum sieboldii<\/i> essential oil on ovalbumin induced allergic rhinitis in rat"],"prefix":"10.1042","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1633-5521","authenticated-orcid":false,"given":"Zhicheng","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haoran","family":"Kang","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology, The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, People\u2019s Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,6,2]]},"reference":[{"key":"2021111620114901500_B1","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1007\/s40266-016-0425-7","article-title":"Pharmacological management of allergic rhinitis in the elderly","volume":"34","author":"Bozek","year":"2017","journal-title":"Drugs Aging"},{"key":"2021111620114901500_B2","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1055\/s-0038-1649492","article-title":"Comparison of 1\u03b1-25-dihydroxyvitamin D3 and IgE levels between allergic rhinitis patients and healthy people","volume":"22","author":"Demir","year":"2018","journal-title":"Int. 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