{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T21:19:09Z","timestamp":1791839949781,"version":"4.3.4"},"reference-count":27,"publisher":"Portland Press Ltd.","issue":"11","license":[{"start":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T00:00:00Z","timestamp":1571356800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,11,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objectives: To investigate the association between dectin-1 gene single nucleotide polymorphisms (SNPs) and susceptibility to fungal infection (FI). Methods: Databases were searched electronically and manually to identify case\u2013control studies concerning dectin-1 SNPs and FI, which were published up to 12 November 2018. The Newcastle\u2013Ottawa Quality Assessment Scale was used to determine the study quality and bias. The SNP frequencies of the B (the variant or minor allele) and A (the wild or major allele) alleles of the dectin-1 gene in both cases and controls were analyzed with regard to FI susceptibility. Results: Eight high-quality studies were included in the review. Systemic review of the included studies demonstrated that dectin-1 SNPs rs3901533 and rs7309123 might be associated with susceptibility to invasive pulmonary aspergillosis infection; moreover, rs16910527 SNP can possibly increase the susceptibility to oropharyngeal candidiasis in HIV-positive patients. The meta-analysis identified significant associations between dectin-1 SNPs and overall FI risk in the homozygote model (pooled odds ratio (OR) 1.77, P=0.04). When classified by subtypes, significant associations were also found for deep FI in the homozygote model (pooled OR 2.46, P=0.01) and the recessive model (pooled OR 2.85, P=0.002). There appeared to be no significant association between dectin-1 SNPs and superficial FI. Conclusion: Systemic review of the included studies suggested that dectin-1 SNPs rs3901533, rs7309123, and rs16910527 might play a role in FI susceptibility. The meta-analysis provided convincing evidence that dectin-1 SNPs might have an important role in FI susceptibility, especially for deep FI.<\/jats:p>","DOI":"10.1042\/bsr20191519","type":"journal-article","created":{"date-parts":[[2019,10,18]],"date-time":"2019-10-18T10:32:32Z","timestamp":1571394752000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Association between dectin-1 gene single nucleotide polymorphisms and fungal infection: a systemic review and meta-analysis"],"prefix":"10.1042","volume":"39","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4305-643X","authenticated-orcid":false,"given":"Peiru","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Xie","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimin","family":"Yan","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaosong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1198-508X","authenticated-orcid":false,"given":"Hong","family":"Hua","sequence":"additional","affiliation":[{"name":"Department of Oral Medicine, Peking University School and Hospital of Stomatology, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,11,13]]},"reference":[{"key":"2021111619531949300_B1","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1007\/978-1-4939-6515-1_1","article-title":"Current challenges in the diagnosis of fungal infections","volume":"1508","author":"Lass-Florl","year":"2017","journal-title":"Methods Mol. 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