{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T22:09:29Z","timestamp":1787004569328,"version":"build-2736575974"},"reference-count":39,"publisher":"Portland Press Ltd.","issue":"12","license":[{"start":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T00:00:00Z","timestamp":1574640000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>The aim of the present study was to determine the roles of microRNA (miR)-146a on myocardial infarction (MI)-induced heart failure and cardiac remodeling. Experiments were carried out in Sprague-Dawley rats treated with ligation of left coronary artery to induce heart failure, and in primary neonatal rat cardiac fibroblasts (CFs) and cardiomyocytes treated with angiotensin (Ang) II. Four weeks after MI, rats were injected with miR-146a antagomiR or agomiR via tail vein. After 2 weeks of injection, the rats were killed. In MI rats, left ventricle (LV) ejection fraction and fractional shortening were reduced, and LV volumes in diastole and systole were increased, which were reversed by miR-146a antagomiR, and further exacerbated after miR-146a agomiR treatment. Administration of miR-146a antagomiR improved the decreases of LV \u00b1dp\/dtmax and LV systolic pressure (LVSP), and the increase in LV end-diastolic pressure (LVEDP) of MI rats, but miR-146a agomiR deteriorated the LV \u00b1dp\/dtmax, LVSP and LVEDP. The increases in the levels of atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), collagen I and collagen III in the heart, and ST2 and norepinephrine in the serum of MI rats were inhibited by miR-146a antagomiR, but aggravated after miR-146a agomiR treatment. The increases of collagen I and collagen III levels induced by Ang II in CFs, and the increases of ANP and BNP levels induced by Ang II in cardiomyocytes were inhibited by miR-146a antagomiR, but aggravated by miR-146a agomiR. These results demonstrated that inhibition of miR-146a improved cardiac dysfunction and cardiac remodeling in heart failure rats.<\/jats:p>","DOI":"10.1042\/bsr20191732","type":"journal-article","created":{"date-parts":[[2019,11,25]],"date-time":"2019-11-25T06:21:48Z","timestamp":1574662908000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Inhibition of microRNA-146a attenuated heart failure in myocardial infarction rats"],"prefix":"10.1042","volume":"39","author":[{"given":"Junjie","family":"He","sequence":"first","affiliation":[{"name":"Lianshui County People\u2019s Hospital, Huaian, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaozheng","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Cardiology, Shengli Oilfield Central Hospital, Dongying, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoxuan","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9619-1694","authenticated-orcid":false,"given":"Yong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Cardiology, the First Affiliated Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"2021111619554115800_B1","doi-asserted-by":"publisher","first-page":"e56","DOI":"10.1161\/CIR.0000000000000659","article-title":"Heart Disease and Stroke Statistics-2019 Update: A Report From the American Heart Association","volume":"139","author":"Benjamin","year":"2019","journal-title":"Circulation"},{"key":"2021111619554115800_B2","doi-asserted-by":"publisher","first-page":"1810","DOI":"10.1161\/CIR.0b013e31829e8807","article-title":"2013 ACCF\/AHA guideline for the management of heart failure: executive summary: a report of the American College of Cardiology Foundation\/American Heart Association Task Force on practice guidelines","volume":"128","author":"Yancy","year":"2013","journal-title":"Circulation"},{"key":"2021111619554115800_B3","doi-asserted-by":"publisher","first-page":"1039","DOI":"10.1161\/CIRCULATIONAHA.117.031841","article-title":"Persistent Long-Term Structural, Functional, and Metabolic Changes After Stress-Induced (Takotsubo) Cardiomyopathy","volume":"137","author":"Scally","year":"2018","journal-title":"Circulation"},{"key":"2021111619554115800_B4","doi-asserted-by":"publisher","first-page":"502","DOI":"10.3390\/ijms17040502","article-title":"MicroRNA and Heart Failure","volume":"17","author":"Wong","year":"2016","journal-title":"Int. J. Mol. Sci."},{"key":"2021111619554115800_B5","doi-asserted-by":"publisher","first-page":"698","DOI":"10.1161\/CIRCHEARTFAILURE.110.938175","article-title":"Predictors of incident heart failure in a large insured population: a one million person-year follow-up study","volume":"3","author":"Goyal","year":"2010","journal-title":"Circ. Heart Fail."},{"key":"2021111619554115800_B6","doi-asserted-by":"publisher","first-page":"491","DOI":"10.1161\/CIRCHEARTFAILURE.113.000978","article-title":"Probiotic administration attenuates myocardial hypertrophy and heart failure after myocardial infarction in the rat","volume":"7","author":"Gan","year":"2014","journal-title":"C.irc Heart Fail."},{"key":"2021111619554115800_B7","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.12659\/MSM.906123","article-title":"Sulforaphane, a Natural Isothiocyanate Compound, Improves Cardiac Function and Remodeling by Inhibiting Oxidative Stress and Inflammation in a Rabbit Model of Chronic Heart Failure","volume":"24","author":"Ma","year":"2018","journal-title":"Med. Sci. Monit."},{"key":"2021111619554115800_B8","doi-asserted-by":"publisher","first-page":"954","DOI":"10.1161\/CIRCULATIONAHA.115.012427","article-title":"Sphingosine-1-Phosphate Receptor Agonist Fingolimod Increases Myocardial Salvage and Decreases Adverse Postinfarction Left Ventricular Remodeling in a Porcine Model of Ischemia\/Reperfusion","volume":"133","author":"Santos-Gallego","year":"2016","journal-title":"Circulation"},{"key":"2021111619554115800_B9","doi-asserted-by":"publisher","first-page":"e001597","DOI":"10.1161\/JAHA.114.001597","article-title":"Impaired right ventricular hemodynamics indicate preclinical pulmonary hypertension in patients with metabolic syndrome","volume":"4","author":"Gopal","year":"2015","journal-title":"J. Am. Heart Assoc."},{"key":"2021111619554115800_B10","doi-asserted-by":"publisher","first-page":"584","DOI":"10.1016\/j.ymthe.2018.11.011","article-title":"Therapeutic Delivery of miR-148a Suppresses Ventricular Dilation in Heart Failure","volume":"27","author":"Raso","year":"2018","journal-title":"Mol. Ther."},{"key":"2021111619554115800_B11","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1016\/S0092-8674(04)00045-5","article-title":"MicroRNAs: genomics, biogenesis, mechanism, and function","volume":"116","author":"Bartel","year":"2004","journal-title":"Cell"},{"key":"2021111619554115800_B12","doi-asserted-by":"publisher","first-page":"5399","DOI":"10.1002\/jcp.27445","article-title":"The role of microRNAs regulating the expression of matrix metalloproteinases (MMPs) in breast cancer development, progression, and metastasis","volume":"234","author":"Javadian","year":"2018","journal-title":"J. Cell. Physiol."},{"key":"2021111619554115800_B13","doi-asserted-by":"publisher","first-page":"219","DOI":"10.1161\/CIRCRESAHA.110.227496","article-title":"The art of microRNA research","volume":"108","author":"van Rooij","year":"2011","journal-title":"Circ. Res."},{"key":"2021111619554115800_B14","doi-asserted-by":"publisher","first-page":"3","DOI":"10.1055\/s-0034-1397344","article-title":"Overview of microRNA biology","volume":"35","author":"Mohr","year":"2015","journal-title":"Semin. Liver Dis."},{"key":"2021111619554115800_B15","doi-asserted-by":"publisher","first-page":"1466","DOI":"10.1161\/CIRCULATIONAHA.112.001207","article-title":"MicroRNA29: a mechanistic contributor and potential biomarker in atrial fibrillation","volume":"127","author":"Dawson","year":"2013","journal-title":"Circulation"},{"key":"2021111619554115800_B16","doi-asserted-by":"publisher","first-page":"706","DOI":"10.1016\/j.ahj.2012.08.004","article-title":"Relation of circulating MicroRNA-133a concentrations with myocardial damage and clinical prognosis in ST-elevation myocardial infarction","volume":"164","author":"Eitel","year":"2012","journal-title":"Am. Heart J."},{"key":"2021111619554115800_B17","doi-asserted-by":"publisher","first-page":"747","DOI":"10.1161\/CIRCULATIONAHA.116.024171","article-title":"Inhibition of MicroRNA-146a and Overexpression of Its Target Dihydrolipoyl Succinyltransferase Protect Against Pressure Overload-Induced Cardiac Hypertrophy and Dysfunction","volume":"136","author":"Heggermont","year":"2017","journal-title":"Circulation"},{"key":"2021111619554115800_B18","doi-asserted-by":"publisher","first-page":"253","DOI":"10.1080\/1354750X.2016.1204001","article-title":"AT1 receptor blocker azilsartan medoxomil normalizes plasma miR-146a and miR-342-3p in a murine heart failure model","volume":"22","author":"Kaneko","year":"2017","journal-title":"Biomarkers"},{"key":"2021111619554115800_B19","doi-asserted-by":"publisher","first-page":"672","DOI":"10.4049\/jimmunol.1403155","article-title":"Attenuation of Cardiac Dysfunction in Polymicrobial Sepsis by MicroRNA-146a Is Mediated via Targeting of IRAK1 and TRAF6 Expression","volume":"195","author":"Gao","year":"2015","journal-title":"J. Immunol."},{"key":"2021111619554115800_B20","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1161\/CIRCRESAHA.118.312751","article-title":"miR-146a Suppresses SUMO1 Expression and Induces Cardiac Dysfunction in Maladaptive Hypertrophy","volume":"123","author":"Oh","year":"2018","journal-title":"Circ. Res."},{"key":"2021111619554115800_B21","doi-asserted-by":"publisher","first-page":"e25784","DOI":"10.1371\/journal.pone.0025784","article-title":"Inhibition of cardiac sympathetic afferent reflex and sympathetic activity by baroreceptor and vagal afferent inputs in chronic heart failure","volume":"6","author":"Gan","year":"2011","journal-title":"PLoS One"},{"key":"2021111619554115800_B22","first-page":"4042509","article-title":"Mitochondria Associated MicroRNA Expression Profiling of Heart Failure","volume":"2017","author":"Wang","year":"2017","journal-title":"Biomed. Res. Int."},{"key":"2021111619554115800_B23","doi-asserted-by":"publisher","first-page":"6141902","DOI":"10.1155\/2018\/6141902","article-title":"Emerging Role of mTOR Signaling-Related miRNAs in Cardiovascular Diseases","volume":"2018","author":"Samidurai","year":"2018","journal-title":"Oxid Med. Cell. Longev."},{"key":"2021111619554115800_B24","doi-asserted-by":"publisher","first-page":"1073","DOI":"10.1038\/aps.2018.30","article-title":"miRNAS in cardiovascular diseases: potential biomarkers, therapeutic targets and challenges","volume":"39","author":"Zhou","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"2021111619554115800_B25","first-page":"4246","article-title":"Endothelial stem cells attenuate cardiac apoptosis via downregulating cardiac microRNA-146a in a rat model of coronary heart disease","volume":"16","author":"Fang","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"2021111619554115800_B26","doi-asserted-by":"publisher","first-page":"867","DOI":"10.17219\/acem\/68945","article-title":"Rise in antifibrotic and decrease in profibrotic microRNA protect the heart against fibrosis during pregnancy: A preliminary study","volume":"27","author":"Szczerba","year":"2018","journal-title":"Adv. Clin. Exp. Med."},{"key":"2021111619554115800_B27","doi-asserted-by":"publisher","first-page":"1081","DOI":"10.1242\/dmm.020768","article-title":"miR-146a targets Fos expression in human cardiac cells","volume":"8","author":"Palomer","year":"2015","journal-title":"Dis. Model. Mech."},{"key":"2021111619554115800_B28","doi-asserted-by":"publisher","first-page":"H1423","DOI":"10.1152\/ajpheart.01211.2011","article-title":"Assessing left ventricular systolic dysfunction after myocardial infarction: are ejection fraction and dP\/dt(max) complementary or redundant?","volume":"302","author":"Ishikawa","year":"2012","journal-title":"Am. J. Physiol. Heart Circulat. Physiol."},{"key":"2021111619554115800_B29","doi-asserted-by":"publisher","first-page":"233","DOI":"10.1159\/000437090","article-title":"Circulating MicroRNA-146a and MicroRNA-21 Predict Left Ventricular Remodeling after ST-Elevation Myocardial Infarction","volume":"132","author":"Liu","year":"2015","journal-title":"Cardiology"},{"key":"2021111619554115800_B30","doi-asserted-by":"publisher","first-page":"1931","DOI":"10.1016\/j.jacc.2019.01.056","article-title":"Empagliflozin Ameliorates Adverse Left Ventricular Remodeling in Nondiabetic Heart Failure by Enhancing Myocardial Energetics","volume":"73","author":"Santos-Gallego","year":"2019","journal-title":"J. Am. Coll. Cardiol."},{"key":"2021111619554115800_B31","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1056\/NEJMoa042330","article-title":"N-terminal pro-B-type natriuretic peptide and long-term mortality in stable coronary heart disease","volume":"352","author":"Kragelund","year":"2005","journal-title":"N. Engl. J. Med."},{"key":"2021111619554115800_B32","doi-asserted-by":"publisher","first-page":"690","DOI":"10.1161\/01.CIR.94.4.690","article-title":"Prognostic significance of plasma norepinephrine in patients with asymptomatic left ventricular dysfunction. Solvd Investigators","volume":"94","author":"Benedict","year":"1996","journal-title":"Circulation"},{"key":"2021111619554115800_B33","doi-asserted-by":"publisher","first-page":"827","DOI":"10.1159\/000495368","article-title":"Hyperoside Protects Against Pressure Overload-Induced Cardiac Remodeling via the AKT Signaling Pathway","volume":"51","author":"Wang","year":"2018","journal-title":"Cell. Physiol. Biochem."},{"key":"2021111619554115800_B34","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1016\/j.phrs.2009.11.012","article-title":"Molecular targets and regulators of cardiac hypertrophy","volume":"61","author":"Rohini","year":"2010","journal-title":"Pharmacol. Res."},{"key":"2021111619554115800_B35","doi-asserted-by":"publisher","first-page":"e011830","DOI":"10.1161\/JAHA.118.011830","article-title":"Novel Role for Pleckstrin Homology-Like Domain Family A, Member 3 in the Regulation of Pathological Cardiac Hypertrophy","volume":"8","author":"Liu","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"2021111619554115800_B36","doi-asserted-by":"publisher","first-page":"e0159079","DOI":"10.1371\/journal.pone.0159079","article-title":"Selumetinib, an Oral Anti-Neoplastic Drug, May Attenuate Cardiac Hypertrophy via Targeting the ERK Pathway","volume":"11","author":"Li","year":"2016","journal-title":"PLoS One"},{"key":"2021111619554115800_B37","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1016\/j.toxlet.2016.03.008","article-title":"Bisphenol A, an environmental estrogen-like toxic chemical, induces cardiac fibrosis by activating the ERK1\/2 pathway","volume":"250-251","author":"Hu","year":"2016","journal-title":"Toxicol. Lett."},{"key":"2021111619554115800_B38","doi-asserted-by":"publisher","first-page":"354","DOI":"10.1161\/CIRCRESAHA.116.310529","article-title":"Paradoxical Suppression of Atherosclerosis in the Absence of microRNA-146a","volume":"121","author":"Cheng","year":"2017","journal-title":"Circ. Res."},{"key":"2021111619554115800_B39","doi-asserted-by":"publisher","first-page":"892","DOI":"10.1161\/ATVBAHA.117.310597","article-title":"MiR-146a Regulates Neutrophil Extracellular Trap Formation That Predicts Adverse Cardiovascular Events in Patients With Atrial Fibrillation","volume":"38","author":"Arroyo","year":"2018","journal-title":"Arterioscler. Thromb. Vasc. Biol."}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20191732\/864803\/bsr-2019-1732.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20191732\/864803\/bsr-2019-1732.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T15:37:12Z","timestamp":1637077032000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/39\/12\/BSR20191732\/221324\/Inhibition-of-microRNA-146a-attenuated-heart"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,12]]},"references-count":39,"journal-issue":{"issue":"12","published-print":{"date-parts":[[2019,12,20]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20191732","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2019,12]]},"published":{"date-parts":[[2019,12]]},"article-number":"BSR20191732"}}