{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T15:20:00Z","timestamp":1790522400356,"version":"4.1.0"},"reference-count":30,"publisher":"Portland Press Ltd.","issue":"12","license":[{"start":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T00:00:00Z","timestamp":1575590400000},"content-version":"vor","delay-in-days":5,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Many common pathological features have been observed for both autism spectrum disorders (ASDs) and obsessive-compulsive disorder (OCD). However, no systematic analysis of the common gene markers associated with both ASD and OCD has been conducted so far. Here, two batches of large-scale literature-based disease\u2013gene relation data (updated in 2017 and 2019, respectively) and gene expression data were integrated to study the possible association between OCD and ASD at the genetic level. Genes linked to OCD and ASD present significant overlap (P-value &amp;lt;2.64e-39). A genetic network of over 20 genes was constructed, through which OCD and ASD may exert influence on each other. The 2017-based analysis suggested six potential common risk genes for OCD and ASD (CDH2, ADCY8, APOE, TSPO, TOR1A, and OLIG2), and the 2019-based study identified two more genes (DISP1 and SETD1A). Notably, the gene APOE identified by the 2017-based analysis has been implicated to have an association with ASD in a recent study (2018) with DNA methylation analysis. Our results support the possible complex genetic associations between OCD and ASD. Genes linked to one disease are worth further investigation as potential risk factors for the other.<\/jats:p>","DOI":"10.1042\/bsr20191942","type":"journal-article","created":{"date-parts":[[2019,12,6]],"date-time":"2019-12-06T07:09:10Z","timestamp":1575616150000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Integrative analysis of shared genetic pathogenesis by autism spectrum disorder and obsessive-compulsive disorder"],"prefix":"10.1042","volume":"39","author":[{"given":"Dongbai","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Neurology, The First People\u2019s Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, 215006, China"},{"name":"Department of Neurology, Jiangyin People\u2019s Hospital, Jiangyin, Jiangsu Province, 214400, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongbao","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, First Hospital\/First Clinical Medical College of Shanxi Medical University, Taiyuan, Shanxi Province, 030001, China"},{"name":"Department of Genomics Research, R&D Solutions, Elsevier Inc., Rockville, MD 20852, U.S.A."},{"name":"School of Systems Biology, George Mason University, Fairfax, VA 22030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamil\u00a0Can","family":"Kural","sequence":"additional","affiliation":[{"name":"School of Systems Biology, George Mason University, Fairfax, VA 22030, U.S.A."}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4099-5594","authenticated-orcid":false,"given":"Qi","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Neurology, The First People\u2019s Hospital Affiliated to Soochow University, Suzhou, Jiangsu Province, 215006, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuquan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Psychiatry, The Affiliated Brain Hospital of Nanjing Medical University, Nanjing, Jiansu Province, 210029, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2019,12,23]]},"reference":[{"key":"2021111619570656200_B1","doi-asserted-by":"publisher","first-page":"1173","DOI":"10.1017\/S1461145711001829","article-title":"Evidence-based pharmacotherapy of obsessive-compulsive disorder","volume":"15","author":"Fineberg","year":"2012","journal-title":"Int. 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