{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,19]],"date-time":"2025-11-19T07:01:33Z","timestamp":1763535693336,"version":"3.41.2"},"reference-count":66,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T00:00:00Z","timestamp":1583280000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Aim: The present study aims to evaluate protective effects of a novel histidine\u2013tryptophan\u2013ketoglutarate solution (HTK-N) and to investigate positive impacts of an additional luminal preservation route in cold storage-induced injury on rat small bowels.<\/jats:p>\n               <jats:p>Methods: Male Lewis rats were utilized as donors of small bowel grafts. Vascular or vascular plus luminal preservation were conducted with HTK or HTK-N and grafts were stored at 4\u00b0C for 8 h followed by ex vivo warm oxygenated reperfusion with Krebs\u2013Henseleit buffer for 30 min. Afterwards, intestinal tissue and portal vein effluent samples were collected for evaluation of morphological alterations, mucosal permeability and graft vitality.<\/jats:p>\n               <jats:p>Results: The novel HTK-N decreased ultrastructural alterations but otherwise presented limited effect on protecting small bowel from ischemia\u2013reperfusion injury in vascular route. However, the additional luminal preservation led to positive impacts on the integrity of intestinal mucosa and vitality of goblet cells. In addition, vascular plus luminal preservation route with HTK significantly protected the intestinal tissue from edema.<\/jats:p>\n               <jats:p>Conclusion: HTK-N protected the intestinal mucosal structure and graft vitality as a luminal preservation solution. Additional luminal preservation route in cold storage was shown to be promising.<\/jats:p>","DOI":"10.1042\/bsr20191989","type":"journal-article","created":{"date-parts":[[2020,3,4]],"date-time":"2020-03-04T11:29:16Z","timestamp":1583321356000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A novel histidine\u2013tryptophan\u2013ketoglutarate formulation ameliorates intestinal injury in a cold storage and <i>ex vivo<\/i> warm oxygenated reperfusion model in rats"],"prefix":"10.1042","volume":"40","author":[{"given":"Zhiquan","family":"Chen","sequence":"first","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7841-9384","authenticated-orcid":false,"given":"Linus","family":"Kebschull","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel\u00a0Arno","family":"F\u00f6ll","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ursula","family":"Rauen","sequence":"additional","affiliation":[{"name":"Institut f\u00fcr Physiologische Chemie, Universit\u00e4tsklinikum Essen, Essen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Uwe","family":"Hansen","sequence":"additional","affiliation":[{"name":"Abteilung f\u00fcr Molekulare Medizin, Institut f\u00fcr Muskuloskeletale Medizin, Westf\u00e4lische Wilhelms-Universit\u00e4t, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbara","family":"Heitplatz","sequence":"additional","affiliation":[{"name":"Gerhard Domagk Institut f\u00fcr Pathologie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Hessler","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr An\u00e4sthesie, Operative Intensivmedizin und Schmerztherapie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Norbert","family":"Senninger","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Vogel","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annika","family":"Mohr","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Becker","sequence":"additional","affiliation":[{"name":"Klinik f\u00fcr Allgemein-, Viszeral- und Transplanationschirurgie, Universit\u00e4tsklinikum M\u00fcnster, M\u00fcnster, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,5,4]]},"reference":[{"key":"2021111620044317700_B1","doi-asserted-by":"publisher","first-page":"998","DOI":"10.1056\/NEJMra0804605","article-title":"Intestinal transplantation","volume":"361","author":"Fishbein","year":"2009","journal-title":"N. 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