{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T12:42:44Z","timestamp":1776688964744,"version":"3.51.2"},"reference-count":95,"publisher":"Portland Press Ltd.","issue":"12","license":[{"start":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T00:00:00Z","timestamp":1573430400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2019,12,20]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Objectives In the present study, we examined available articles from online databases to comprehensively investigate the effect of the XPC (xeroderma pigmentosum complementation group C) rs2228000 polymorphism on the risk of different types of clinical cancer.<\/jats:p>\n               <jats:p>Methods We conducted a group of overall and subgroup pooling analyses after retrieving the data from four databases (updated till September 2019). The P-value of association, OR (odds ratios), and 95% CI (confidence interval) were calculated.<\/jats:p>\n               <jats:p>Results We selected a total of 71 eligible studies with 26835 cancer cases and 37069 controls from the 1186 retrieved articles. There is an enhanced susceptibility for bladder cancer cases under T vs. C [P=0.004; OR (95% CI) = 1.25 (1.07, 1.45)], TT vs. CC [P=0.001; 1.68 (1.25, 2.26)], CT+TT vs. CC [P=0.016; 1.26 (1.04, 1.53)], and TT vs. CC+ CT [P=0.001; 1.49 (1.18, 1.90)] compared with negative controls. Additionally, there is an increased risk of breast cancer under T vs. C, TT vs. CC and TT vs. CC+ CT (P&amp;lt;0.05, OR &amp;gt; 1). Nevertheless, there is a decreased risk of gastric cancer cases in China under T vs. C [P=0.020; 0.92 (0.85, 0.99)], CT vs. CC [P=0.001, 0.83 (0.73, 0.93)], and CT+TT vs. CC [P=0.003, 0.84 (0.76, 0.94)].<\/jats:p>\n               <jats:p>Conclusions The TT genotype of XPC rs2228000 may be linked to an increased risk of bladder and breast cancer, whereas the CT genotype is likely to be associated with reduced susceptibility to gastric cancer in the Chinese population.<\/jats:p>","DOI":"10.1042\/bsr20192452","type":"journal-article","created":{"date-parts":[[2019,11,11]],"date-time":"2019-11-11T11:57:53Z","timestamp":1573473473000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Comprehensive assessment of the association between <i>XPC<\/i> rs2228000 and cancer susceptibility based on 26835 cancer cases and 37069 controls"],"prefix":"10.1042","volume":"39","author":[{"given":"Yingqi","family":"Dai","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Shandong Provincial Third Hospital, Shandong 250031, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhonghua","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Breast Surgery, Shandong Provincial Third Hospital, Shandong 250031, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1415-9621","authenticated-orcid":false,"given":"Jinqing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Oncology, Shandong Provincial Third Hospital, Shandong 250031, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Interventional Therapy, Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Tianjin 300060, P.R. China"},{"name":"Key Laboratory of Cancer Prevention and Therapy, Tianjin 300060, P.R. China"},{"name":"Tianjin\u2019s Clinical Research Center for Cancer, Huan Hu West Road, Tianjin 300060, P.R. China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2019,12,4]]},"reference":[{"key":"2021111619543754100_B1","doi-asserted-by":"publisher","first-page":"81","DOI":"10.1186\/1471-2407-7-81","article-title":"Sequence variations in DNA repair gene XPC is associated with lung cancer risk in a Chinese population: a case-control study","volume":"7","author":"Bai","year":"2007","journal-title":"BMC Cancer"},{"key":"2021111619543754100_B2","doi-asserted-by":"crossref","first-page":"1633","DOI":"10.1158\/1055-9965.EPI-07-0252","article-title":"Potentially functional single nucleoticle polymorphisms in the core nucleoticle excision repair genes and risk of squamous cell carcinoma of the head and neck","volume":"16","author":"An","year":"2007","journal-title":"Cancer Epidemiol. 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