{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,14]],"date-time":"2026-09-14T10:21:53Z","timestamp":1789381313925,"version":"build-2803163510"},"reference-count":30,"publisher":"Portland Press Ltd.","issue":"3","license":[{"start":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T00:00:00Z","timestamp":1582243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,3,27]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Hypoglycemia is a common metabolic condition in neonatal period, but severe and persistent hypoglycemia can cause neurological damage and brain injury. The aim of the present study was to analyze the risk factors of neonatal hypoglycemia in clinic. A total of 135 neonatal hypoglycemia infants and 135 healthy infants were included in the present study. The differences in birth weight between neonatal hypoglycemia group and healthy control group were analyzed via t test. The associations between neonatal blood sugar level and relevant characteristic factors were explored using \u03c72 test. Binary logistic regression analysis was used to analyze risk factors related to the incidence of neonatal hypoglycemia. The results showed that the average birth weight was matched in neonatal hypoglycemia group and healthy control group. Neonatal blood sugar level of the infants was significantly associated with born term, birth weight, feed, gestational diabetes mellitus (GDM) and hypothermia (all P&amp;lt;0.05). Besides, logistic regression analysis showed that babies\u2019 born term (odds ratio (OR) = 2.715, 95% confidence interval (95% CI): 1.311\u20135.625), birth weight (OR = 1.910, 95% CI: 1.234\u20132.955), improper feeding (OR = 3.165, 95% CI: 1.295\u20137.736) and mother\u2019s GDM (OR = 2.184, 95% CI: 1.153\u20134.134) were high risk factors for neonatal hypoglycemia. The incidence of hypoglycemia in infants was significantly associated with various clinical factors. And monitoring these risk factors is one of important measures to reduce long-term neurological damage caused by neonatal hypoglycemia.<\/jats:p>","DOI":"10.1042\/bsr20192589","type":"journal-article","created":{"date-parts":[[2020,2,21]],"date-time":"2020-02-21T11:29:09Z","timestamp":1582284549000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Identifying risk effectors involved in neonatal hypoglycemia occurrence"],"prefix":"10.1042","volume":"40","author":[{"given":"Tian","family":"Zhao","sequence":"first","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiying","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Dai","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Kuang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqiong","family":"Ming","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8427-5172","authenticated-orcid":false,"given":"Guiyu","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Guizhou Provincial People\u2019s Hospital, Guizhou 550002, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"288","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"2021111620035171900_B1","doi-asserted-by":"publisher","first-page":"232","DOI":"10.4269\/ajtmh.13-0016","article-title":"Blood glucose as a predictor of mortality in children admitted to the hospital with febrile illness in Tanzania","volume":"89","author":"Nadjm","year":"2013","journal-title":"Am. J. Trop. Med. Hyg."},{"key":"2021111620035171900_B2","doi-asserted-by":"publisher","first-page":"1485","DOI":"10.1016\/j.jpeds.2014.01.015","article-title":"50 years ago in the Journal of pediatrics: the incidence of neonatal hypoglycemia in a nursery for premature infants","volume":"164","author":"Houin","year":"2014","journal-title":"J. Pediatr."},{"key":"2021111620035171900_B3","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/j.siny.2013.09.003","article-title":"Defining neonatal hypoglycaemia: a continuing debate","volume":"19","author":"Tin","year":"2014","journal-title":"Semin. Fetal Neonatal Med."},{"key":"2021111620035171900_B4","doi-asserted-by":"publisher","first-page":"E55","DOI":"10.1111\/j.1440-1754.2009.01599.x","article-title":"A survey of the management of neonatal hypoglycaemia within the Australian and New Zealand Neonatal Network","volume":"50","author":"Harris","year":"2014","journal-title":"J. Paediatr. Child Health"},{"key":"2021111620035171900_B5","doi-asserted-by":"publisher","first-page":"1093","DOI":"10.1111\/dmcn.12496","article-title":"Variable outcome for epilepsy after neonatal hypoglycaemia","volume":"56","author":"Fong","year":"2014","journal-title":"Dev. Med. Child Neurol."},{"key":"2021111620035171900_B6","doi-asserted-by":"publisher","first-page":"1169","DOI":"10.1007\/s00431-007-0653-2","article-title":"Repetitive and profound insulin-induced hypoglycemia results in brain damage in newborn rats: an approach to establish an animal model of brain injury induced by neonatal hypoglycemia","volume":"167","author":"Zhou","year":"2008","journal-title":"Eur. J. Pediatr."},{"key":"2021111620035171900_B7","doi-asserted-by":"publisher","first-page":"76","DOI":"10.1111\/dmcn.13014","article-title":"Cerebral palsy and perinatal mortality after pregnancy-induced hypertension across the gestational age spectrum: observations of a reconstructed total population cohort","volume":"58","author":"Blair","year":"2016","journal-title":"Dev. Med. Child Neurol."},{"key":"2021111620035171900_B8","doi-asserted-by":"publisher","first-page":"462","DOI":"10.3345\/kjp.2012.55.12.462","article-title":"Effect of early postnatal neutropenia in very low birth weight infants born to mothers with pregnancy-induced hypertension","volume":"55","author":"Park","year":"2012","journal-title":"Korean J. Pediatr."},{"key":"2021111620035171900_B9","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1186\/s13098-016-0200-2","article-title":"Diagnostic protocol for gestational diabetes mellitus (GDM) (IADPSG\/ADA, 2011): influence on the occurrence of GDM and mild gestational hyperglycemia (MGH) and on the perinatal outcomes","volume":"9","author":"Sirimarco","year":"2017","journal-title":"Diabetol. Metab. Syndr."},{"key":"2021111620035171900_B10","doi-asserted-by":"publisher","first-page":"560","DOI":"10.1016\/j.ajog.2015.06.022","article-title":"Timing of treatment initiation for mild gestational diabetes mellitus and perinatal outcomes","volume":"213","author":"Palatnik","year":"2015","journal-title":"Am. J. Obstet. Gynecol."},{"key":"2021111620035171900_B11","first-page":"97","article-title":"Comparison of glyburide and insulin in women with gestational diabetes mellitus and associated perinatal outcome: a randomized clinical trial","volume":"53","author":"Mirzamoradi","year":"2015","journal-title":"Acta Med. Iran."},{"key":"2021111620035171900_B12","first-page":"418","article-title":"Alanine aminotransferase as a predictor of adverse perinatal outcomes in women with intrahepatic cholestasis of pregnancy","volume":"32","author":"Ekiz","year":"2016","journal-title":"Pak. J. Med. Sci."},{"key":"2021111620035171900_B13","doi-asserted-by":"publisher","first-page":"1883","DOI":"10.1111\/jog.12444","article-title":"Role of postprandial bile acids in prediction of perinatal outcome in intrahepatic cholestasis of pregnancy","volume":"40","author":"Sargin Oruc","year":"2014","journal-title":"J. Obstet. Gynaecol. Res."},{"key":"2021111620035171900_B14","doi-asserted-by":"publisher","first-page":"33","DOI":"10.1016\/j.neuint.2015.02.002","article-title":"Glucose metabolism and astrocyte-neuron interactions in the neonatal brain","volume":"82","author":"Brekke","year":"2015","journal-title":"Neurochem. Int."},{"key":"2021111620035171900_B15","doi-asserted-by":"publisher","first-page":"e151","DOI":"10.1111\/dme.12135","article-title":"Hypoglycaemia-induced changes in regional brain volume and memory function","volume":"30","author":"Kirchhoff","year":"2013","journal-title":"Diabetes Med."},{"key":"2021111620035171900_B16","doi-asserted-by":"publisher","first-page":"84","DOI":"10.1038\/pr.2014.146","article-title":"Hyperglycemia accentuates and ketonemia attenuates hypoglycemia-induced neuronal injury in the developing rat brain","volume":"77","author":"Ennis","year":"2015","journal-title":"Pediatr. Res."},{"key":"2021111620035171900_B17","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1007\/s00540-015-2070-4","article-title":"Intraoperative severe hypoglycemia indicative of post-hepatectomy liver failure","volume":"30","author":"Chung","year":"2016","journal-title":"J. Anesth."},{"key":"2021111620035171900_B18","doi-asserted-by":"publisher","first-page":"234","DOI":"10.2169\/internalmedicine.44.234","article-title":"Severe starvation hypoglycemia and congestive heart failure induced by thyroid crisis, with accidentally induced severe liver dysfunction and disseminated intravascular coagulation","volume":"44","author":"Kobayashi","year":"2005","journal-title":"Intern. Med."},{"key":"2021111620035171900_B19","doi-asserted-by":"publisher","first-page":"2","DOI":"10.1136\/archdischild-2012-302569","article-title":"Hypoglycaemia and neonatal brain injury","volume":"98","author":"Boardman","year":"2013","journal-title":"Arch. Dis. Child Educ. Pract. Ed."},{"key":"2021111620035171900_B20","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1016\/j.jpeds.2012.05.022","article-title":"Incidence of neonatal hypoglycemia in babies identified as at risk","volume":"161","author":"Harris","year":"2012","journal-title":"J. Pediatr."},{"key":"2021111620035171900_B21","doi-asserted-by":"publisher","first-page":"649","DOI":"10.1016\/j.braindev.2008.10.012","article-title":"Associated factors in neonatal hypoglycemic brain injury","volume":"31","author":"Montassir","year":"2009","journal-title":"Brain Dev."},{"key":"2021111620035171900_B22","doi-asserted-by":"publisher","first-page":"1456","DOI":"10.3174\/ajnr.A3423","article-title":"Brain injury patterns in hypoglycemia in neonatal encephalopathy","volume":"34","author":"Wong","year":"2013","journal-title":"AJNR Am. J. Neuroradiol."},{"key":"2021111620035171900_B23","first-page":"769","article-title":"Unfavourable outcomes associated with late preterm birth: observations from Jordan","volume":"61","author":"Abu-Salah","year":"2011","journal-title":"J. Pak. Med. Assoc."},{"key":"2021111620035171900_B24","doi-asserted-by":"publisher","first-page":"1337","DOI":"10.3109\/14767058.2013.784250","article-title":"Very low birth weight preterm infants are at risk for hypoglycemia once on total enteral nutrition","volume":"26","author":"Staffler","year":"2013","journal-title":"J. Matern. Fetal Neonatal Med."},{"key":"2021111620035171900_B25","doi-asserted-by":"publisher","first-page":"2181","DOI":"10.1111\/jocn.12488","article-title":"Association between neonatal hypoglycaemia and prediabetes in postpartum women with a history of gestational diabetes","volume":"23","author":"Youngwanichsetha","year":"2014","journal-title":"J. Clin. Nurs."},{"key":"2021111620035171900_B26","doi-asserted-by":"publisher","first-page":"217","DOI":"10.1016\/j.diabres.2012.03.011","article-title":"A prospective evaluation of neonatal hypoglycaemia in infants of women with gestational diabetes mellitus","volume":"97","author":"Flores-le Roux","year":"2012","journal-title":"Diabetes Res. Clin. Pract."},{"key":"2021111620035171900_B27","doi-asserted-by":"publisher","first-page":"359","DOI":"10.3233\/NPM-15915014","article-title":"Improving neonatal complications with a structured multidisciplinary approach to gestational diabetes mellitus management","volume":"8","author":"Rahmani","year":"2015","journal-title":"J. Neonatal Perinatal Med."},{"key":"2021111620035171900_B28","first-page":"CD011027","article-title":"Oral dextrose gel for the treatment of hypoglycaemia in newborn infants","volume":"4","author":"Weston","year":"2016","journal-title":"Cochrane Database Syst. Rev."},{"key":"2021111620035171900_B29","doi-asserted-by":"publisher","first-page":"120","DOI":"10.1186\/s12887-015-0440-6","article-title":"Randomised trial of neonatal hypoglycaemia prevention with oral dextrose gel (hPOD): study protocol","volume":"15","author":"Harding","year":"2015","journal-title":"BMC Pediatr."},{"key":"2021111620035171900_B30","first-page":"97","article-title":"Neonatal hypoglycemia: risk factors and outcomes","volume":"38","author":"Stomnaroska","year":"2017","journal-title":"Pril. (Makedon Akad. Nauk. Umet. Odd. Med. Nauki)"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20192589\/869471\/bsr-2019-2589.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20192589\/869471\/bsr-2019-2589.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:41:47Z","timestamp":1637095307000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/3\/BSR20192589\/222179\/Identifying-risk-effectors-involved-in-neonatal"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":30,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2020,3,27]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20192589","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,3]]},"published":{"date-parts":[[2020,3]]},"article-number":"BSR20192589"}}