{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T03:42:00Z","timestamp":1777002120964,"version":"3.51.4"},"reference-count":45,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T00:00:00Z","timestamp":1588032000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Background and aims: Postoperative pain can cause serious adverse reactions that severely affect postoperative outcome. The present study evaluated the effect of dexmedetomidine (DEX) added to sufentanil in intravenous patient-controlled analgesia (PCA) on the relief of pain and inflammatory responses during postoperative recovery of patients undergoing a combined thoracoscopic-laparoscopic esophagectomy (TLE). Methods: Sixty patients undergoing TLE were randomly allocated to receive 1 \u03bcg\/ml of sufentanil alone (Group S) or 1 \u03bcg\/ml of sufentanil plus 2.5 \u03bcg\/ml of DEX (Group D) for postoperative intravenous (IV) PCA. Postoperative pain relief, cumulative PCA requirements, inflammatory marker levels, delirium and recovery were assessed. Results: A joint DEX and sufentanil regimen significantly reduced the area under the curve of numerical rating scores for pain at rest (NRSR) and coughing (NRSC) at 1\u201348 h postoperatively (P = 0.000) that were associated with lower PCA-delivered cumulative sufentanil consumption and less PCA frequency until 48 h postoperatively (P &amp;lt; 0.05 and P &amp;lt; 0.0001, respectively). The simultaneous administration of DEX and sufentanil significantly reduced plasma IL-6 and TNF-\u03b1 concentrations and increased IL-10 level (P &amp;lt; 0.0001, P = 0.0003 and P = 0.0345, respectively), accompanied by better postoperative delirium categories and health statuses of patients (P = 0.024 and P &amp;lt; 0.05, respectively). There was no hypotension, bradycardia, respiratory depression or oversedation in Group D. Conclusion: Patients receiving DEX in addition to IV PCA sufentanil for TLE exhibited better postoperative analgesia, fewer inflammatory responses and lower postoperative delirium categories and better health statuses.<\/jats:p>","DOI":"10.1042\/bsr20193410","type":"journal-article","created":{"date-parts":[[2020,4,28]],"date-time":"2020-04-28T13:29:40Z","timestamp":1588080580000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":41,"title":["Dexmedetomidine with sufentanil in intravenous patient-controlled analgesia for relief from postoperative pain, inflammation and delirium after esophageal cancer surgery"],"prefix":"10.1042","volume":"40","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-028X","authenticated-orcid":false,"given":"Chaoliang","family":"Tang","sequence":"first","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yida","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhetao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zeyuan","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Pharmacy, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hongtao","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qingtian","family":"Geng","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Si","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiawu","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaoqing","family":"Chai","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui 230001, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"288","published-online":{"date-parts":[[2020,5,11]]},"reference":[{"key":"2021111620101396600_B1","doi-asserted-by":"publisher","first-page":"381","DOI":"10.1007\/s00464-011-1883-y","article-title":"Effectiveness of combined thoracoscopic-laparoscopic esophagectomy: comparison of postoperative complications and midterm oncological outcomes in patients with esophageal cancer","volume":"26","author":"Kinjo","year":"2012","journal-title":"Surg. Endosc"},{"key":"2021111620101396600_B2","doi-asserted-by":"publisher","first-page":"966","DOI":"10.1053\/j.jvca.2013.12.007","article-title":"Single-dose, bilateral paravertebral block plus intravenous sufentanil analgesia in patients with esophageal cancer undergoing combined thoracoscopic-laparoscopic esophagectomy: a safe and effective alternative","volume":"28","author":"Zhang","year":"2014","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"2021111620101396600_B3","doi-asserted-by":"publisher","first-page":"29","DOI":"10.2147\/JPR.S188568","article-title":"Postoperative analgesia after combined thoracoscopic-laparoscopic esophagectomy: a randomized comparison of continuous infusion and intermittent bolus thoracic epidural regimens","volume":"12","author":"Wei","year":"2019","journal-title":"J. Pain Res."},{"key":"2021111620101396600_B4","doi-asserted-by":"publisher","first-page":"630","DOI":"10.1093\/bja\/aet192","article-title":"Effect of ketamine as an adjunct to intravenous patient-controlled analgesia, in patients at high risk of postoperative nausea and vomiting undergoing lumbar spinal surgery","volume":"111","author":"Song","year":"2013","journal-title":"Br. J. Anaesth."},{"key":"2021111620101396600_B5","doi-asserted-by":"publisher","first-page":"1066","DOI":"10.1097\/00000542-200411000-00005","article-title":"Dexmedetomidine pharmacodynamics: part I: crossover comparison of the respiratory effects of dexmedetomidine and remifentanil in healthy volunteers","volume":"101","author":"Hsu","year":"2004","journal-title":"Anesthesiology"},{"key":"2021111620101396600_B6","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1097\/00000542-200411000-00006","article-title":"Dexmedetomidine pharmacodynamics: Part II: Crossover comparison of the analgesic effect of dexmedetomidine and remifentanil in healthy volunteers","volume":"101","author":"Cortinez","year":"2004","journal-title":"Anesthesiology"},{"key":"2021111620101396600_B7","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1097\/00000542-200409000-00028","article-title":"Dexmedetomidine as a total intravenous anesthetic agent","volume":"101","author":"Ramsay","year":"2004","journal-title":"Anesthesiology"},{"key":"2021111620101396600_B8","doi-asserted-by":"publisher","first-page":"1899","DOI":"10.2147\/JPR.S139387","article-title":"Dexmedetomidine in perioperative acute pain management: a non-opioid adjuvant analgesic","volume":"10","author":"Tang","year":"2017","journal-title":"J. Pain Res."},{"key":"2021111620101396600_B9","doi-asserted-by":"publisher","first-page":"363","DOI":"10.1517\/14656566.2011.521743","article-title":"Adjuvant analgesics in acute pain","volume":"12","author":"Lui","year":"2011","journal-title":"Exp. Opin. Pharmacother."},{"key":"2021111620101396600_B10","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/j.vaa.2020.01.007","article-title":"Comparison of intraperitoneal ropivacaine and ropivacaine-dexmedetomidine for postoperative analgesia in cats undergoing ovariohysterectomy","volume":"47","author":"Nicacio","year":"2020","journal-title":"Vet. Anaesth. Analg."},{"key":"2021111620101396600_B11","doi-asserted-by":"publisher","first-page":"864","DOI":"10.1111\/j.1365-2044.2011.06883.x","article-title":"Enhanced recovery programmes; coming to a hospital near you!","volume":"66","author":"Morris","year":"2011","journal-title":"Anaesthesia"},{"key":"2021111620101396600_B12","doi-asserted-by":"publisher","first-page":"6501248","DOI":"10.1155\/2017\/6501248","article-title":"Lung-Protective Ventilation Strategies for Relief from Ventilator-Associated Lung Injury in Patients Undergoing Craniotomy: A Bicenter Randomized, Parallel, and Controlled Trial","volume":"2017","author":"Tang","year":"2017","journal-title":"Oxid Med. Cell. Longev."},{"key":"2021111620101396600_B13","doi-asserted-by":"publisher","first-page":"215","DOI":"10.1111\/aas.12445","article-title":"Intranasal dexmedetomidine in combination with patient-controlled sedation during upper gastrointestinal endoscopy: a randomised trial","volume":"59","author":"Cheung","year":"2015","journal-title":"Acta Anaesthesiol. Scand."},{"key":"2021111620101396600_B14","doi-asserted-by":"publisher","first-page":"1332","DOI":"10.1097\/ALN.0b013e318289b84b","article-title":"Development and psychometric evaluation of a postoperative quality of recovery score: the QoR-15","volume":"118","author":"Stark","year":"2013","journal-title":"Anesthesiology"},{"key":"2021111620101396600_B15","doi-asserted-by":"publisher","first-page":"526","DOI":"10.7326\/M13-1927","article-title":"The CAM-S: development and validation of a new scoring system for delirium severity in 2 cohorts","volume":"160","author":"Inouye","year":"2014","journal-title":"Ann. Intern. Med."},{"key":"2021111620101396600_B16","first-page":"1","article-title":"Intranasal Dexmedetomidine on Stress Hormones, Inflammatory Markers, and Postoperative Analgesia after Functional Endoscopic Sinus Surgery","volume":"2015","author":"Tang","year":"2015","journal-title":"Mediators Inflamm."},{"key":"2021111620101396600_B17","doi-asserted-by":"publisher","first-page":"117","DOI":"10.1093\/bja\/aen320","article-title":"Effect of combining dexmedetomidine and morphine for intravenous patient-controlled analgesia","volume":"102","author":"Lin","year":"2009","journal-title":"Br. J. Anaesth."},{"key":"2021111620101396600_B18","doi-asserted-by":"publisher","first-page":"2849","DOI":"10.1517\/14656566.2010.511613","article-title":"Alpha-2 agonists in acute pain management","volume":"11","author":"Chan","year":"2010","journal-title":"Exp. Opin. Pharmacother."},{"key":"2021111620101396600_B19","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1097\/EJA.0000000000000011","article-title":"Effect of dexmedetomidine combined with sufentanil for post-caesarean section intravenous analgesia: a randomised, placebo-controlled study","volume":"31","author":"Nie","year":"2014","journal-title":"Eur. J. Anaesthesiol."},{"key":"2021111620101396600_B20","doi-asserted-by":"publisher","first-page":"1015","DOI":"10.1053\/j.jvca.2016.03.127","article-title":"Effect of Oxycodone Combined With Dexmedetomidine for Intravenous Patient-Controlled Analgesia After Video-Assisted Thoracoscopic Lobectomy","volume":"30","author":"Wang","year":"2016","journal-title":"J. Cardiothorac. Vasc. Anesth."},{"key":"2021111620101396600_B21","doi-asserted-by":"publisher","first-page":"2644","DOI":"10.1001\/jama.298.22.2644","article-title":"Effect of sedation with dexmedetomidine vs lorazepam on acute brain dysfunction in mechanically ventilated patients: the MENDS randomized controlled trial","volume":"298","author":"Pandharipande","year":"2007","journal-title":"JAMA"},{"key":"2021111620101396600_B22","doi-asserted-by":"publisher","first-page":"833","DOI":"10.1016\/j.jss.2013.06.062","article-title":"Clinical benefits of dexmedetomidine versus propofol in adult intensive care unit patients: a meta-analysis of randomized clinical trials","volume":"185","author":"Xia","year":"2013","journal-title":"J. Surg. Res."},{"key":"2021111620101396600_B23","doi-asserted-by":"publisher","first-page":"489","DOI":"10.1001\/jama.2009.56","article-title":"Dexmedetomidine vs midazolam for sedation of critically ill patients: a randomized trial","volume":"301","author":"Riker","year":"2009","journal-title":"JAMA"},{"key":"2021111620101396600_B24","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1097\/00019442-200401000-00002","article-title":"Delirium in elderly patients","volume":"12","author":"Cole","year":"2004","journal-title":"Am. J. Geriatr. Psychiatry"},{"key":"2021111620101396600_B25","first-page":"665","article-title":"Drug delivery system to improve the perioperative administration of intravenous drugs: computer assisted continuous infusion (CACI)","volume":"81","author":"Glass","year":"1995","journal-title":"Anesth. Analg."},{"key":"2021111620101396600_B26","doi-asserted-by":"publisher","first-page":"184","DOI":"10.1016\/j.neulet.2003.12.007","article-title":"Recent findings on how proinflammatory cytokines cause pain: peripheral mechanisms in inflammatory and neuropathic hyperalgesia","volume":"361","author":"Sommer","year":"2004","journal-title":"Neurosci. Lett."},{"key":"2021111620101396600_B27","first-page":"1001","article-title":"Continuous regional anesthesia and inflammation: a new target","volume":"81","author":"Grosu","year":"2015","journal-title":"Minerva Anestesiol."},{"key":"2021111620101396600_B28","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.2147\/JPR.S139365","article-title":"Sex differences in complex regional pain syndrome type I (CRPS-I) in mice","volume":"10","author":"Tang","year":"2017","journal-title":"J Pain Res."},{"key":"2021111620101396600_B29","doi-asserted-by":"publisher","first-page":"280","DOI":"10.1097\/00000542-200301000-00047","article-title":"Preemptive analgesia: what do we do now?","volume":"98","author":"Gottschalk","year":"2003","journal-title":"Anesthesiology"},{"key":"2021111620101396600_B30","doi-asserted-by":"publisher","first-page":"S197","DOI":"10.1007\/s10072-010-0325-2","article-title":"Sphenopalatine endoscopic ganglion block in cluster headache: a reevaluation of the procedure after 5 years","volume":"31","author":"Pipolo","year":"2010","journal-title":"Neurol. Sci.: Off. J. Italian Neurol. Soc. Italian Soc. Clin. Neurophysiol."},{"key":"2021111620101396600_B31","doi-asserted-by":"publisher","first-page":"573","DOI":"10.1016\/j.jamcollsurg.2019.12.021","article-title":"Loss of Independence in Older Patients after Operation for Colorectal Cancer","volume":"230","author":"Gearhart","year":"2020","journal-title":"J. Am. Coll. Surg."},{"key":"2021111620101396600_B32","doi-asserted-by":"publisher","first-page":"309","DOI":"10.1177\/1089253215570062","article-title":"Cognitive Dysfunction, Delirium, and Stroke in Cardiac Surgery Patients","volume":"19","author":"Cropsey","year":"2015","journal-title":"Semin. Cardiothorac. Vasc. Anesth."},{"key":"2021111620101396600_B33","doi-asserted-by":"publisher","first-page":"2706","DOI":"10.1016\/j.clinthera.2015.09.012","article-title":"Missed Opportunities for Intervention in a Patient With Prolonged Postoperative Delirium","volume":"37","author":"Whalin","year":"2015","journal-title":"Clin. Ther."},{"key":"2021111620101396600_B34","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4103\/1673-5374.226399","article-title":"Neuroprotective effect of bispectral index-guided fast-track anesthesia using sevoflurane combined with dexmedetomidine for intracranial aneurysm embolization","volume":"13","author":"Tang","year":"2018","journal-title":"Neural Regen. Res."},{"key":"2021111620101396600_B35","doi-asserted-by":"publisher","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"key":"2021111620101396600_B36","doi-asserted-by":"publisher","first-page":"277","DOI":"10.1016\/j.bpa.2012.07.003","article-title":"Epidemiology and risk factors for delirium across hospital settings","volume":"26","author":"Vasilevskis","year":"2012","journal-title":"Best Pract. Res. Clin. Anaesthesiol."},{"key":"2021111620101396600_B37","doi-asserted-by":"publisher","first-page":"1893","DOI":"10.1016\/S0140-6736(16)30580-3","article-title":"Dexmedetomidine for prevention of delirium in elderly patients after non-cardiac surgery: a randomised, double-blind, placebo-controlled trial","volume":"388","author":"Su","year":"2016","journal-title":"Lancet"},{"key":"2021111620101396600_B38","doi-asserted-by":"publisher","first-page":"444","DOI":"10.1056\/NEJMra1208705","article-title":"Sedation and delirium in the intensive care unit","volume":"370","author":"Reade","year":"2014","journal-title":"N. Engl. J. Med."},{"key":"2021111620101396600_B39","doi-asserted-by":"publisher","first-page":"749","DOI":"10.1001\/jama.2016.0701","article-title":"Critical Care and the Brain","volume":"315","author":"Tasker","year":"2016","journal-title":"JAMA"},{"key":"2021111620101396600_B40","doi-asserted-by":"publisher","first-page":"153","DOI":"10.1186\/cc13930","article-title":"Inflammation biomarkers and delirium in critically ill patients: new insights?","volume":"18","author":"Sobbi","year":"2014","journal-title":"Crit. Care"},{"key":"2021111620101396600_B41","first-page":"993","article-title":"Incidence and risk factors of delirium in critically ill patients after non-cardiac surgery","volume":"123","author":"Shi","year":"2010","journal-title":"Chin. Med. J. (Engl.)"},{"key":"2021111620101396600_B42","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1097\/00000542-200302000-00024","article-title":"The alpha2-adrenoceptor agonist dexmedetomidine converges on an endogenous sleep-promoting pathway to exert its sedative effects","volume":"98","author":"Nelson","year":"2003","journal-title":"Anesthesiology"},{"key":"2021111620101396600_B43","doi-asserted-by":"publisher","first-page":"709","DOI":"10.3233\/JAD-181288","article-title":"The Reliability and Validity of the Chinese Version of Confusion Assessment Method Based Scoring System for Delirium Severity (CAM-S)","volume":"69","author":"Mei","year":"2019","journal-title":"J. Alzheimers Dis."},{"key":"2021111620101396600_B44","doi-asserted-by":"publisher","first-page":"1393","DOI":"10.1111\/jgs.15867","article-title":"Delirium Incidence and Functional Outcomes After Transcatheter and Surgical Aortic Valve Replacement","volume":"67","author":"Shi","year":"2019","journal-title":"J. Am. Geriatr. Soc."},{"key":"2021111620101396600_B45","doi-asserted-by":"publisher","first-page":"e1260","DOI":"10.1212\/WNL.0000000000008164","article-title":"Clinical EEG slowing correlates with delirium severity and predicts poor clinical outcomes","volume":"93","author":"Kimchi","year":"2019","journal-title":"Neurology"}],"container-title":["Bioscience Reports"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20193410\/878886\/bsr-2019-3410.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/portlandpress.com\/bioscirep\/article-pdf\/doi\/10.1042\/BSR20193410\/878886\/bsr-2019-3410.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,11,16]],"date-time":"2021-11-16T20:46:17Z","timestamp":1637095577000},"score":1,"resource":{"primary":{"URL":"https:\/\/portlandpress.com\/bioscirep\/article\/40\/5\/BSR20193410\/222794\/Dexmedetomidine-with-sufentanil-in-intravenous"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,5]]},"references-count":45,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2020,5,29]]}},"URL":"https:\/\/doi.org\/10.1042\/bsr20193410","relation":{},"ISSN":["0144-8463","1573-4935"],"issn-type":[{"value":"0144-8463","type":"print"},{"value":"1573-4935","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2020,5]]},"published":{"date-parts":[[2020,5]]},"article-number":"BSR20193410"}}