{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T04:13:25Z","timestamp":1791000805242,"version":"4.1.0"},"reference-count":42,"publisher":"Portland Press Ltd.","issue":"5","license":[{"start":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T00:00:00Z","timestamp":1589414400000},"content-version":"vor","delay-in-days":13,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["portlandpress.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2020,5,29]]},"abstract":"<jats:title>Abstract<\/jats:title>\n               <jats:p>Myocardial ischemia\/reperfusion (MI\/R) triggers a complicated chain of inflammatory reactions. Dexmedetomidine (Dex) has been reported to be important in myocardial disorders. We evaluated the role of Dex in MI\/R injury via the silent information regulator factor 2-related enzyme 1 (SIRT1)\/mammalian target of rapamycin (mTOR) signaling pathway. First, Dex was immediately injected into rat models of MI\/R injury during reperfusion. After Evans Blue-triphenyl tetrazolium chloride (TTC) and Hematoxylin\u2013Eosin (H-E) staining, MI\/R injury was observed. The extracted serum and myocardial tissues were used to detect oxidative stress and the inflammatory response. Western blot analysis was performed to evaluate MI\/R autophagy and the levels of proteins associated with the SIRT1\/mTOR axis. The effects of the combination of Dex and SIRT1 inhibitor EX527 on MI\/R injury and autophagy were evaluated. Finally, the mechanism of Dex was tested, and autophagy levels and the levels of proteins associated with the SIRT1\/mTOR signaling pathway were assessed in MI\/R rats. The results of the present study suggested that Dex relieved MI\/R injury, reduced cardiomyocyte apoptosis, oxidative stress and inflammatory reactions, up-regulated the SIRT1\/mTOR axis and decreased overautophagy in MI\/R rats. SIRT1 inhibitor EX527 attenuated the protective effects of Dex. Our study demonstrated that Dex alleviated MI\/R injury by activating the SIRT1\/mTOR axis. This investigation may offer new insight into the treatment of MI\/R injury.<\/jats:p>","DOI":"10.1042\/bsr20194030","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T13:24:13Z","timestamp":1589462653000},"update-policy":"https:\/\/doi.org\/10.1042\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dexmedetomidine postconditioning suppresses myocardial ischemia\/reperfusion injury by activating the SIRT1\/mTOR axis"],"prefix":"10.1042","volume":"40","author":[{"given":"Xiong","family":"Zhang","sequence":"first","affiliation":[{"name":"Guangzhou First People\u2019s Hospital, School of Medicine, South China University of Technology, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongxing","family":"Li","sequence":"additional","affiliation":[{"name":"Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Wang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuerong","family":"Zhuang","sequence":"additional","affiliation":[{"name":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojie","family":"Ren","sequence":"additional","affiliation":[{"name":"The First Clinical School, Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-8615","authenticated-orcid":false,"given":"Wuhua","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ming","family":"Zhong","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, Guangzhou 510405, Guangdong, P.R. 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